Doctor insights on:
What Organs Are Affected By Parkinsons Disease
Why can t healthy dopaminergic neurons be moved into the area of parkinson s affected neurons to treat parkinson s disease?
Not so simple: Most of the dopaminergic neurons end in the substantia nigra of the midbrain, originating in various deep brain structures. These nerves are already affected by the disease. Unaffected nerves of course still remain but remain connected to brainstem. So outside nerve cells (from another source like stem cells are needed) nerves don't like to be moved around anyway, because they often die.
Disease of misfolded: Proteins, affecting numerous neurotransmitters, especially a Dopamine deficit. Main brain systems include basal ganglia (especially substantial nigra), but also dorsal vagal nucleus, locus ceruleous, and pallidum. But we are now finding areas of pathology in the gut (meissner's plexus), so this may be more systemic than we used to think.
Older males: Typically, there are about 3 times as many males as females, but not fully clear why there is this predilection. Usually a disease presenting in the 60's and 70's, but younger patients can be seen. There may be a higher frequency in Caucasians.
Parkinsonism: Yes. There is evidence that certain chemicals and pesticides can cause parkinsonism. We are now experiencing an epidemic of parkinsonism but it is not clear why this is happening.See 1 more doctor answer
Can you tell me in Parkinson's disease, does dopamine loss occur merely in the striatum or does it occur in the s.niagra too?
Pigmented nuclei: The dopamine loss involves predominantly the basal ganglia area, but also involves dorsal vagal nucleus, substantial nigra, and areas of any dopamine interaction within brain and brain stem. But, to be complete, Parkinson's is a multi-neurotransmitter degenerative deficiency syndrome with other neurotransmitter systems involved.
Yes: Although the causes are multifactorial and sometimes poorly understood, there is a hereditary component. Keep in mind, that even though a parent may have it, it does not mean that it will be necessarily passed on. The tendency, however, may be there.See 2 more doctor answers
Its relative: The question doesn't really make sense because comparing morbidity of different diseases is impossible. Suffice it to say, infortunately, that there are many bad diseases to suffer from abd that most of them end badly.
Neurodegenerative: Parkinson’s results from destruction of dopamine-producing neurons in part of the brain (substantia nigra). A lack of these neurons causes decreased excitation of the motor part of the brain. This results in the classic signs of a resting tremor (“pill-rolling”), slowness of movement (shuffling steps), rigidity (resistance to being moved), and postural instability (balance issues).See 2 more doctor answers
Yes: Parkinson-like symptoms can be an initial manifestation of Wilson's disease. Wilson's disease usually occurs in younger people, however. If there is any confusion in diagnosis, Wilson's disease can usually be diagnosed through a combination of blood tests, urine tests, and/or an eye exam. Hope this helps.
Modernize Treatment!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person.See 1 more doctor answer
Good History & Exam!: Physical symptoms can include tremor of limbs at rest>in posture or in action; slow movements & stiff (rigid) muscles causing quiet facial emotions, softer voice, bent forward head & neck posture, decreased arm swing, slow-shuffled walk, small/scratchy penmanship, etc. Non-physical symptoms can include cognitive decline, depression, anxiety, sleepiness, constipation, ed, low bp, acting-out dreams.See 1 more doctor answer
None: There is no cure for parkinsons disease. There are about two dozen medicines for parkinson's, some 60 years old, others five years old. Each of them does something a little different. There is also surgery for a select group of patients with parkinsons. Talk to your neurologist.
Parkinson's ds: Neurologists are usually consulted for this condition as it affects a specific portion of the brain. They can prescribe med to slow development of ds and suggest other beneficial treatments.
Here's a brief list: Physical symptoms can include tremor of limbs at rest>in posture or in action; slow movements & stiff (rigid) muscles causing quiet facial emotions, softer voice, bent forward head & neck posture, decreased arm swing, slow-shuffled walk, small/scratchy penmanship, etc. Non-physical symptoms can include cognitive decline, depression, anxiety, sleepiness, constipation, ed, low bp, acting-out dreams.
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