Doctor insights on:
What Organs Are Affected By Parkinsons Disease
Why can t healthy dopaminergic neurons be moved into the area of parkinson s affected neurons to treat parkinson s disease?
Not so simple: Most of the dopaminergic neurons end in the substantia nigra of the midbrain, originating in various deep brain structures. These nerves are already affected by the disease. Unaffected nerves of course still remain but remain connected to brainstem. So outside nerve cells (from another source like stem cells are needed) nerves don't like to be moved around anyway, because they often die. ...Read more
Disease of misfolded: Proteins, affecting numerous neurotransmitters, especially a Dopamine deficit. Main brain systems include basal ganglia (especially substantial nigra), but also dorsal vagal nucleus, locus ceruleous, and pallidum. But we are now finding areas of pathology in the gut (meissner's plexus), so this may be more systemic than we used to think. ...Read more
Older males: Typically, there are about 3 times as many males as females, but not fully clear why there is this predilection. Usually a disease presenting in the 60's and 70's, but younger patients can be seen. There may be a higher frequency in Caucasians. ...Read more
Parkinsonism: Yes. There is evidence that certain chemicals and pesticides can cause parkinsonism. We are now experiencing an epidemic of parkinsonism but it is not clear why this is happening. ...Read more
In Parkinson's disease, does dopamine loss happen mainly in the striatum or does it occur in the s.Niagra too?
Parkinson: Basal ganglia, which includes both.Get a more detailed answer ›
Can you tell me in Parkinson's disease, does dopamine loss occur merely in the striatum or does it occur in the s.niagra too?
Pigmented nuclei: The dopamine loss involves predominantly the basal ganglia area, but also involves dorsal vagal nucleus, substantial nigra, and areas of any dopamine interaction within brain and brain stem. But, to be complete, Parkinson's is a multi-neurotransmitter degenerative deficiency syndrome with other neurotransmitter systems involved. ...Read more
Yes: Although the causes are multifactorial and sometimes poorly understood, there is a hereditary component. Keep in mind, that even though a parent may have it, it does not mean that it will be necessarily passed on. The tendency, however, may be there. ...Read more
Its relative: The question doesn't really make sense because comparing morbidity of different diseases is impossible. Suffice it to say, infortunately, that there are many bad diseases to suffer from abd that most of them end badly. ...Read more
Neurodegenerative: Parkinson’s results from destruction of dopamine-producing neurons in part of the brain (substantia nigra). A lack of these neurons causes decreased excitation of the motor part of the brain. This results in the classic signs of a resting tremor (“pill-rolling”), slowness of movement (shuffling steps), rigidity (resistance to being moved), and postural instability (balance issues). ...Read more
Yes: Parkinson-like symptoms can be an initial manifestation of Wilson's disease. Wilson's disease usually occurs in younger people, however. If there is any confusion in diagnosis, Wilson's disease can usually be diagnosed through a combination of blood tests, urine tests, and/or an eye exam. Hope this helps. ...Read more
Modernize Treatment!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person. ...Read more
Good History & Exam!: Physical symptoms can include tremor of limbs at rest>in posture or in action; slow movements & stiff (rigid) muscles causing quiet facial emotions, softer voice, bent forward head & neck posture, decreased arm swing, slow-shuffled walk, small/scratchy penmanship, etc. Non-physical symptoms can include cognitive decline, depression, anxiety, sleepiness, constipation, ed, low bp, acting-out dreams. ...Read more
Parkinson's ds: Neurologists are usually consulted for this condition as it affects a specific portion of the brain. They can prescribe med to slow development of ds and suggest other beneficial treatments. ...Read more
Here's a brief list: Physical symptoms can include tremor of limbs at rest>in posture or in action; slow movements & stiff (rigid) muscles causing quiet facial emotions, softer voice, bent forward head & neck posture, decreased arm swing, slow-shuffled walk, small/scratchy penmanship, etc. Non-physical symptoms can include cognitive decline, depression, anxiety, sleepiness, constipation, ed, low bp, acting-out dreams. ...Read more
Tremor: Early, there may be a resting tremor unilaterally, and perhaps some focal stiffness. Later, the gait may become impaired, with short unsteady steps, and a tendency to fall. The face may become expressionless, drooling may present, and thinking becomes disrupted. Problems with swallowing, constipation, and skin eruptions can also occur. ...Read more
Mayo Clinic!: Usually, a treating neurologist can provide very specific information to a patient. If you want to read on your own, the mayo clinic has a very good webpage (http://www. Mayoclinic. Org/diseases-conditions/parkinsons-disease. ...Read more
Parkinsons disease: Is a degenerative disorder of the central nervous system. The motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with. ...Read more
Brief comments: This is complex as it involves brain stem structures such as locus ceruleus and dorsal nucleus of vagus, in addition to basal ganglia such as substantial nigra and putamen. A specific variety of dementia called Lewy Body disease can accompany. The brain is afflicted and the remainder of body affected secondarily. Good treatment is available. ...Read more
Resting Tremor: Parkinson's disease is charcterized by the constellation of resting tremor, rigidity, and bradykinesia (slowed movements). The resting tremor can start on one side of the body, and when present in the hand is described as"pill-rolling". This tremor is different than intention tremors, seen with movement, or essential tremor. The resting tremor can in time generalize, and worsen in intensity. ...Read more
We don't know yet: As with other neurological disorders, we are still learning about the role of genetics in the development of PD. Approximately 15% of PD patients have a family history. Familial cases of PD can be caused by mutations in known genes, but we still don't fully understand how genetic changes cause PD or influence the risk of developing it. Ref: http://www. Pdf. Org/en/genetics__parkinsons_gwinn ...Read more
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