Doctor insights on:
What Organ Regulates Cholesterol
Complicated: The cholesterol in HDL particles (hdl-c) can increase either because the cholesterol carried per particle goes up, or because the actual number of number of HDL particles (hdl-p) increase. Cholesterol per HDL particle will increase if elevated triglycerides go down, as well as in response to exercise, alcohol, and niacin. Some meds (statins, fibrates, Zetia (ezetimibe) and metformin) increase hdl-p. ...Read more
Poorly defined: It may not even be true. Over the past two decades, there's been much discussion about why the public / diet advisors believe this. There was talk of saturated fats reducing LDL-receptor mediated clearance of LDL's, or saturated fats making LDL receptors less abundant. I tried following this for a while and it never got settled. I remain skeptical. ...Read more
Bone, kidney.: Parathyroid hormone maintains a normal blood calcium by releasing calcium from bone, returning calcium from filtered calcium in the kidney and by stimulating production of active vitamin d in the kidney which helps calcium absorption through the intestine. ...Read moreSee 1 more doctor answer
Many Functions: Hdl cholesterol has many functions. Often thought of as protective, it brings cholesterol from the artery wall back to the liver. It also acts as an anti-oxidant, and an anti-inflammatory agent. It may be involved in helping the artery wall dilate , and may also be involved in fighting some infections. Hdl may also deliver cholesterol to organs that need it during stress. Can be very complex. ...Read moreSee 2 more doctor answers
Cholesterol: Cholesterol is a type of fat that is necessary for a number of functions, it is part of cell membranes, sexual hormones and other necessary substances. It is present in the blood which transports it to various parts of the body, and it is also present in animals. Humans get into trouble by consuming too much cholesterol from animal fats or producing too much cholesterol from dietary fats. ...Read more
Excellent question: Traditional thinking had been that a high fat diet always lead to a high cholesterol level but dr. Atkins has proven that to be wrong. That said, doctors advise against trans-fats and high saturated fat diets. The best diet is a mixture of protein, complex carbs, and monounsaturated and/or polyunsaturated fats. The single most important feature is calorie control and achieving ideal body weight. ...Read more
Liver damage: The liver can be damaged from some medications, excess alcohol intake, hepatitis virus, cancer, etc. Blood tests can detect liver injury by measuring elevated liver enzymes in the blood or elevated ammonia level in the blood. Rising blood levels indicate ongoing liver inflammation or damage. ...Read more
Complex interaction: Phosphoprotein phosphatase is activated by the insulin, which indicates that there is a high concentration of glucose in the blood. The enzyme then acts to dephosphorylate other enzymes. The net effect is for glucose to enter the cell where it can be metabolized andlalso lowers the serum glucose level. ...Read more
Does metformin regulate glucose made by liver? What's best way to treat diabetics, control liver glucose production or pancreatic insulin production?
Yes but there's more: One of metformin's actions is reducing liver glucose production. It also helps improve the body's use of insulin, aka Insulin sensitivity. This is key to long term health with diabetes. Eating smart, exercise, and keeping to a good weight also help. Metformin is our usual first choice & meds that increase pancreatic Insulin production are not , but you & your doc must pick what's best for you. ...Read more
Clears LDL Particles: Ldl is low density lipoprotein, a particle that carries cholesterol in the blood. If LDL particles are increased (high LDL particle number) more particles enter the artery wall and increase cardiovascular disease (cvd) risk. Ldl receptors (ldlr) bind and remove LDL particles from the blood. Low ldlr increases cvd risk. Statin drugs increase ldlr causing lower LDL levels and decreased cvd risk. ...Read more
Mostly Heart: Coronary arteries are the main vessels coming off the aorta supplying blood to the heart muscle. There are 3 main coronary arteries. When they have significant plaques in them (coronary atherosclerosis, or coronary artery disease), people develop chest pains (angina), shortness of breath, chest tightness with exertion, heart attacks and various other consequences. ...Read more
Does the human body naturally produce small LDL particles? Why or what are the functions of small LDL cholesterols in the human body?
LDL function.: LDL cholesterol does have a function in our bodies, so in some respects is necessary. The small dense LDL particles to which you refer, however, are more atherogenic than the other large buoyant LDL particles. Niacin supplementation can improve your LDL subtype, changing small dense LDL to large buoyant LDL. ...Read moreSee 1 more doctor answer
Diabetes?: JimM638, you've hit the nail right square on the head there ! Diabetes ( lack of endogenous insulin production from pancreas) is ALL ABOUT SUGAR CONTROL measured by average sugar level over weeks as measured by HbA1c. The goal is to keep this within normal level. That number varies from lab to lab so look at normals for lab analysing your blood.thanks ...Read more
What endocrine disorder results in abnormal blood sugar levels and increases the risk of heart attack?
Diabetes mellitis: Is this a trick question?Get a more detailed answer ›
If my total cholest is 284 with HDL 100.9 and LDL 177 , trig 79, ratio 2.81. What is more important the levels or the ratio? What the ratio means?
Individual Values: Cardiovascular (cvd) risk is related to the number of LDL particles (ldl-p) and the number of HDL particles (hdl-p). When ldl-p is high or hdl-p is low cvd risk is elevated. Ratios report an LDL number divided by hdl. However, cvd risk can vary by 40% a the same ratio value. This is because you can get the same ratio with different LDL or HDL values (e.g., 2000/50 or 1000/25 give the same ratio). ...Read moreSee 1 more doctor answer
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