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Doctor insights on: What Medications Can I Take With Methotrexate

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Can I take cold medication if I'm taking methotrexate.?

Can I take cold medication if I'm taking methotrexate.?

See below: As a good rule of thumb, if you have an infection, you would want to leave off your Methotrexate and Imuran (azathioprine) and when the infection resolves, you can resume them.

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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How long does the drug methotrexate take to give a reduction in pain levels.?

How long does the drug methotrexate take to give a reduction in pain levels.?

Weeks to months: Methotrexate works by reducing the function of the cells that are causing inflammation in the joint tissues. People with swollen and painful joints whose rheumatoid arthritis has not improved with initial, non-drug therapies will most likely be prescribed methotrexate for RA management. But it may take weeks to several months until the full benefits of methotrexate are noticeable

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If I've already taken my methotrexate for the week, is it ok to take a cold medication? If so, what is safe to use?

If I've already taken my methotrexate for the week, is it ok to take a cold medication? If so, what is safe to use?

Methotrexate: You may take cold medicine with methotrexate. One medicine not to use echinacea but most others are ok.

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I use methotrexate, sorry for the brevity, the drugs I take were initially in the questions and answers. I'm wondering if it matters if I use intra muscular needle or subcutaneous?

I use methotrexate, sorry for the brevity, the drugs I take were initially in the questions and answers. I'm wondering if it matters if I use intra muscular needle or subcutaneous?

No but,,,,: Why take it IM vesus subcutaneously? No good reason! Bioavailability is the same! Plus you leave MTX in the large needle!

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Which medication can reduce rheumatoid factor? My RF is 201. methotrexate not working I take 15 mg weekly one year

RF Factor: RF is a blood test that can be used to evalauted for multiple conditions. In patients with rhumatological conditions there is no evidnece that a drop in the RF value is of any clinical significance while on therapy. The most important considerations for treating RA are the symptoms and any evidnece of joint destruciton on imagining.

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Taking methotrexate and it says u can die if u take it everyday and it's a cancer chemo drug is this true?

Methotrexate: It is used for cancer and also in inflammatory joint disease such as rheumatoid arthritis. In rheumatologiic disorders it is used in smaller doses once a week. Like all drugs it has side effects and needs to be monitored carefully by a rheumatologist or oncologist based on who is prescribing for what reason.

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I'm 67 long past menopause but I've been experiencing "hot flashes" again. I take 10 mg of prednisone daily and a shot of methotrexate weekly. Are these drugs causing flashes?

I'm 67 long past menopause but I've been experiencing "hot flashes" again. I take 10 mg of prednisone daily and a shot of methotrexate weekly. Are these drugs causing flashes?

Possibly: Hormones are a type of steroid. They have similar chemical pathways in which your body can process them. It is also possible that you are having a side effect similar to a hot flash.

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If I take primoultN to postpone my periods, want to know if it is safe while taking Rheumatoid medications Celebrex, (celecoxib)Prednison, sulfasalazi, methotrexate?

If I take primoultN to postpone my periods, want to know if it is safe while taking Rheumatoid medications Celebrex, (celecoxib)Prednison, sulfasalazi, methotrexate?

Don't do. ..: If not absolutely necessary. PrimoultN is a progestin. I could not find any worrisome interactions between this medication and the ones you list. However, both Celebrex (celecoxib) and prednisone (a cortisone drug) might unfavorably affect the blood clotting system; progestins like PrimoultN might promote this. With taking these 4 significant meds, I would avoid anything not absolutely necessary. Best wishes

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I have rheumatoid arthritis and take methotrexate and humira (adalimumab) injections. I want to get look better by getting filler for my face. Please let me know which ones are not in conflict with my medications. Thanks?

Filler options: You need to avoid sculptra with RA as you may be at increased risk for nodule and granuloma formation. Ha fillers like juvederm or Restylane (dermal fillers) should be safe but last only a year or so. Fat transfer is a good long term option but has more down time. Consult with a local experienced facial plastic surgeon.

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Please describe the medication: methotrexate?

Please describe the medication: methotrexate?

Standard therapy: Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases.

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Can I take other medicines if I take methotrexate?

Yes: We use it with a lot of different medications. Whenever you take Methotrexate you need to be monitored. We advise no alcohol because alcohol plus Methotrexate increases the risk of liver disease.

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Is there another medication to treat as besides methotrexate?

Is there another medication to treat as besides methotrexate?

Ankylosing spondylit: As treatment is to reduce inflammation, reduce and prevent complications. Rx consist of pt, breathing exercises, posture and meds. Of meds pain and nsaids are followed by dmrd which include sulfasalazine, steroids, mtx and Cyclosporine. Newer tnf blockers include embrel, humira, Remicade, tociizumab and Rituxan (rituximab). Lung disease, heart (ai), uveitis, joint replacements by specialists

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I took methotrexate for 7 day how long will it take to completely remove from my body?

Methotrexate: Methotrexate has an elimination half life of 3 to 10 hours, therefore it will take approximately 55 hours, about 2.3 days for it to be totally out of your system.

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If I took 1st dose of methotrexate 10mg weekly last friday, can I take it 1-2 days early to switch to wed or thursays from now on?

Yes: I commonly change days by one to two days with my patients. It should not be a problem with your current dose. I would recommend you do this only with the approval of your primary prescribing physician.

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Can I take the 8 pills of Methotrexate once a week or is it better to divide it and take it everyday one pill a day on the 7th day two pills?

Depends: Please talk to your doctor. I am an oncologist and am more familiar with weekly dosing (taken all at once, once per week), but please make sure that is what your doctor intended for your treatment. Thank you.

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If methotrexate is working for ctd, d es one still need to take a break from it after a while (does it build up in the body eventually cause problems?

Not necessarily: Methotrexate can cause cumulative toxicity but your physician should be following lab work regularly. While this not a guarantee against toxicity, it is a very good safeguard. Sometimes, if the disease is clearly in remission, it is reasonable to try and reduce the dosage of medication. However, the old adage "if it ain't broke, don't fix it"often applies.

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Is it harmful to take methotrexate?

Yes, if no indicatio: It will be harmful if no indication to take. However, if there is a strong indication- it is something that is tolerable. Just like any other medication, there will be some possible adverse events- and this is something that you have to discuss with your doctor- to weigh the benefit and the risk and make a decision.

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Dr. Robert Lowe
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