Doctor insights on:
What Kind Of Mutation Is Present In The Brca1 Gene In The Breast Cancer Families
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Genetic mutation: Genetic mutation in long arm of chromosome 17 in brca 1 , in 13 brca 2, instead of normal protective proteins which control abnormal growth of cell , repair broken down dna, maintain genetic stability, the abnormal proteins fail to protect, and responsible for 40% inherited breast cancers, 80% of breast & ovarian cancers. ...Read moreSee 1 more doctor answer
About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?
50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
BRCA: The most commonly described genetic mutations associated with family history include brca1 and brca2 gene mutations. There are several other familial cancer syndromes though, and can be related to other genes such as p53 (li fraumeni syndrome) and pten (cowden's disease). Hereditary genetic syndromes as a whole are rare and comprise only about 10% of patients who have breast cancer. ...Read more
Many: If you inherit mutated brca1 or brca2 from a parent, your odds are greatly increased. All cancers arise from accumulated mutations and natural selection over your own lifetime, but these can actually be passed from parent to child. ...Read more
Gene mutation: If not a genetically inherited , environmental conditions initiate the induction of the breast lesion. The most common mutation occurs with the long terminal repeat of the MMTV virus enters the Wnt-1 gene. This produces an over expression of B-catenin which results in transformation. EBV infection probably needed for FGARAT production that acts to overexpress telomerase inducing immortality. ...Read more
I have extra genetic mutations for breast cancer & heart failure What's the likelihood that these genes will turn on & can I use diet to keep them off?
Complex genetics: Recommendations on gene mutations are best given by a medical geneticist, who needs a detailed understanding of the exact test that you had done and the detailed results. Many gene mutations cause a loss of function so you don't necessarily want to turn off the mutated gene. Modern genetics is discovering many genetic markers that convey only small risk of disease, and may require no treatment. ...Read more
36 year-old woman whose mother was diagnosed with breast cancer at age 34 and a PALB2 mutation wonders if mastectomy is needed to lower her risk.....?
You need testing: If your mother was a BRCA carrier then it is important that you get tested. Since you know that she has a PLAB2 mutation then your testing can even be more precise. If you are a carrier then see an experienced breast surgeon. They can calculate your lifetime risk as well as your 5 year risk to help you make your decisions regarding mastectomy and ovary removal ...Read more
Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 1 more doctor answer
My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?
Yes you are: Breast cancer does have some hereditary tendency. So sisters and daughters of a breat cancer patients have a small increase in their risk for developing breast cancer. yet >90% of the time there is no relationship to such an occurrence. So you need to be vigilant but not worry much about it. Just learn about breast self examination and do annual mammograms beginning at age 40 yr. ...Read moreSee 1 more doctor answer
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
The breast is both a male and female organ. However its main function is in the delivery of milk to the newborn. Breast cancer occurs 95% of the time in women and 5% of the time in men. It is treated the same regardless of which sex it appears in. It comes in two forms invasive and non-invasive; distinction is important as ...Read more
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