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Doctor insights on: What Is Willie Lynch Syndrome

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What is lynch syndrome?

What is lynch syndrome?

Tumor risk: Some folks are born with a defective gene for one of the proteins that you need to maintain the rest of your genes. Around 1 person in 200 is affected; most important is frequent colonoscopy, which greatly the changes of colon cancer (which develops very fast in these folks) spreading out of control. ...Read more

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What percentage of the population has lynch syndrome?

What percentage of the population has lynch syndrome?

1/500 to 1/1000: Lynch syndrome is an inherited disorder that causes an increased risk for colorectal cancer, stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, & skin. Women have high risk for ovarian & uterine cancer. In the usa there are 140, 000 new cases of colorectal cancer yearly; approximately 5 % of these cancers are caused by lynch syndrome.Cancer also happens at a younger age. ...Read more

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Can cannabinoids be used for lynch syndrome?

Lynch Syndrome: Lynch syndrome or hnpcc is an inherited condition of colonic instability that carries a high (80%) lifetime risk of developing colon cancer - particularly of the right sided colon. Surgery is often recommended: http://en.Wikipedia.Org/wiki/hereditary_nonpolyposis_colorectal_cancer. Use of cannabinoids in treating cancer and other pain is controversial, but is no substitute for primary treatments. ...Read more

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What to do if I'm awaiting confirmation from genetics as to whether I have lynch syndrome?

Be patient?: And remember a few things: if positive, look at it from the bright side. Knowing you carry a "bad" gene gives you a tactical advantage so that you can take measures to protect yourself. Your family should also test if you are positive. If negative, you may still be advised to get extra screenings. No test is 100% accurate and there are other syndromes that increase colon cancer risk. Either.... ...Read more

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Should relatives of stage IV lynch syndrome patient (28yrs old) have a colonoscopy? Other tests or procedures? Thank you.

Should relatives of stage IV lynch syndrome patient (28yrs old) have a colonoscopy?  Other tests or procedures?  Thank you.

Need screening plan: Lynch Syndrome (LS) causes increased risk for a number of cancers including colorectal, uterine, kidney, and others. If a family member has a gene change that causes LS, genetic testing of all family members is needed to determine risk and make a cancer prevention plan. Colonoscopy should be considered by age 20 or 2-5 years earlier than the earliest colon cancer if it is diagnosed before age 25. ...Read more

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Lynch syndrome, related to rectal cancer, how likely is it that if someone has this they will get cancer? How many people APPROXIMATELY are fine?

Lynch syndrome, related to rectal cancer, how likely is it that if someone has this they will get cancer? How many people APPROXIMATELY are fine?

Lynch syndrome: Lynch syndrome is also known as hereditary non-polyposis colorectal cancer. Individuals with HNPCC have about an 80% lifetime risk for colon cancer. It is a genetically inherited cancer syndrome that has a greater than 50 % chance of being passed from a parent to an affected child. ...Read more

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Why would i have fuzzy white stools? My family has lynch syndrome, would this be part of that?

Why would i have fuzzy white stools? My family has lynch syndrome, would this be part of that?

See GI Physician: Lynch syndrome put you at risk of many other associated disorders. White stools are always a concern especially of chronic and may be accompanied by dark urine. This can be caused by a number of syndromes or masses that affect the biliary system. Important to get an evaluation. ...Read more

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My first cousin has confirmed lynch syndrome. Mother, aunts, and on dad's side don't have it to my knowledge. Chance of having it based off that?guess

My first cousin has confirmed lynch syndrome. Mother, aunts, and on dad's side don't have it to my knowledge. Chance of having it based off that?guess

Need more detail: Your chance is probably under 25% but difficult without more detail. When you discuss your relatives, on which side of the family are they? Your cousin could be a brand new mutation in the family which would mean you have very little risk. However, your cousin's parent could be a carrier which means that your parent has a 50% chance and you would have a 50% chance to inherit. Baysian risk ...Read more

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History of lynch syndrome. Sisters endometrial biopsy said limited tissue available, but benign. Should it be redone to rule out cancer if symptomatic?

History of lynch syndrome. Sisters endometrial biopsy said limited tissue available, but benign. Should it be redone to rule out cancer if symptomatic?

Lynch syndrome: Lynch syndrome is an inherited condition that increases your risk of colon cancer and other cancers including endometrial cancer in women. If your sister is symptomatic and does have Lynch syndrome a suboptimal biopsy is not sufficient to rule out endometrial pathology. Further workup is warranted. ...Read more

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Is a tubular adenoma colon polyp associated with lynch syndrome?

Is a tubular adenoma colon polyp associated with lynch syndrome?

Not really: lynch syndrome is an inherited disease that will cause polyps that will led to camper Tubular adenoidal is a condition cam happen with or without lynch syndrome ...Read more

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My aunt's daughter has lynch syndrome rectal cancer. Hereditary. My mom and other aunt have no real signs of this.Chance of me having? Mom's son?

My aunt's daughter has lynch syndrome rectal cancer. Hereditary. My mom and other aunt have no real signs of this.Chance of me having? Mom's son?

Low odds: While the odds are very low, they're not zero, and its unpredictable. Check out the American Cancer Society website. They have some good information about this. Hope this helps! ...Read more

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Asked a lot. No responses. I have one relative with lynch syndrome. Rec cancer. I want gene testing on the mLH1 gene. What is the cost of this test?

Asked a lot. No responses. I have one relative with lynch syndrome. Rec cancer. I want gene testing on the mLH1 gene. What is the cost of this test?

Question for path: This test is done by molecular diagnostic companies like Foundation medicine, Caris Dx, pathology departments in moth hospitals. Most MD's may not have an answer to your question. Sorry. ...Read more

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What is the likelyhood of a sudden polyp in gallbladder being cancer after colon cancer in person with lynch syndrome?

What is the likelyhood of a sudden polyp in gallbladder being cancer after colon cancer in person with lynch syndrome?

Low but possible: Cancer of the gallbladder is associated with hnpcc/lynch syndrome but, overall most gallbladder polyps are benign. I would speak with your GI doctor as a cholecystectomy may be advised depending on the size and how long it's been there. ...Read more

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What arethe chances of lynch syndrome if no colon ca runs in the family? I had a sessile adenoma at 27 but no fam history of cancer other than 1 had lungca

What arethe chances of lynch syndrome if no colon ca runs in the family? I had a sessile adenoma at 27 but no fam history of cancer other than 1 had lungca

No chance: Your family history reveals no evidence for lynch syndrome, hereditary non-polyposis colon cancer or other hereditary cancer syndromes based on the information given. Would run out of space here before able to answer fully. If you want further information please refer to the amsterdam criteria and bethesda guidelines. ...Read more

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Can you definitively rule out lynch syndrome in patients tested neg for msi/ihc without germline mutation analysis? If not, what additional indications are required for md to order germline analysis?

Can you definitively rule out lynch syndrome in patients tested neg for msi/ihc without germline mutation analysis? If not, what additional indications are required for md to order germline analysis?

See below: Lynch sydrome is caused by a germline mutation in a gene leading to msi. Combined testing for msi, and using ihc to look for genetic abnormalities leading to msi are the best tests to determine if you have lynch syndrome. Further genetic testing could be done in people who test positive for msi or ihc. Please see: http://www.Mayoclinic.Com/health/lynch-syndrome/ds00669/dsection=tests-and-diagnosis. ...Read more

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What percentage of lynch syndrome patients develop colon polyps by age 60? Not cancer but just polyps

What percentage of lynch syndrome patients develop colon polyps by age 60? Not cancer but just polyps

Colon ca, not polyps: Lynch syndrome affects a minority of patients, as it is a rare condition that is often inherited (in about 30% of pts). Of these pts, about 70% will develop colon cancer - most of them by age 60. The risk is high. But the syndrome causes NON-polyp colon cancer, not polyps. It usually requires colon removal (colectomy) to reduce risk. Use HealthTap Prime or talk to your gastroenterologist about sym ...Read more

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Why does having had endometrial cancer increase risk of colon cancer? I have lynch syndrome but risk would be high anyway?

You have not had : enough or appropriate genetic counseling with regard to Lynch syndrome 1 or 2, to which you are cecertainly entitled. Find out which laboratory tested you for confirmation, by demanding a copy of your laboratory report, to which you are entitled, which will provide you with the number for the Genetics Counselor at that laboratory. He/she will explain the significance to you and for your relatives. ...Read more

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I have lynch syndrome. I am now told to have a hysterectomy. So who should do the surgery.? Gynological oncologist or gynecologist?

I have lynch syndrome.  I am now told to have a hysterectomy.  So who should do the surgery.?  Gynological oncologist or gynecologist?

Either : Removal of uterus, tube and ovaries is an important risk reducing procedure. It is important that your surgeon is familiar with treating patients with hereditary cancer syndromes because how the surgery is done can effect your long term outcome. Also the pathologist needs to know to evaluate for occult cancer. Be sure your surgeon is familiar with treating pt. With genetic cancer risk. ...Read more

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