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Doctor insights on: What Is Von Willebrand

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What is von willebrand's disease?

What is von willebrand's disease?

Von Willebrand ....: Factor . Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii also promotes clotting. So, vwf deficiency also causes secondary fviii dysfunction. Vwf def has many variants. Severity is variable. Most have type i. ...Read more

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Dr. Joseph Torkildson
45 doctors shared insights

Von Willebrand (Definition)

Von Willebrand disease is caused by a deficiency of von Willebrand factor. Von Willebrand factor helps blood platelets clump together and stick to the blood vessel wall, which is necessary for normal blood clotting. There are several types ...Read more


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What is von willebrand's disease ?

What is von willebrand's disease ?

A bleeding problem: Platelets stop bleeding by patching holes in blood vessels. von Willebrand factor is the glue that sticks platelets to those holes. If von Willebrand factor is low, or if the structure of VWF is abnormal, it doesn't stick platelets to the sites of bleeding. Most people have nosebleeds, gum bleeding, or bleeding after tooth extraction. There are 4 types of VW disease with different symptoms. ...Read more

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What is von willebrand's disease type 3?

What is von willebrand's disease type 3?

VonWillebrand type 3: This is severe von willebrand disease. These people may have a total absence of von willebrand factor, and factor viii levels are often less than 10%. Usually inherited in recessive manner (one affected gene from each parent who may not have symptoms). It is essential to see a pediatric hematologist for this disease. ...Read more

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I need to know what is von willebrand's disease?

Bleeding disorder: Von willebrand disease is a condition that can cause extended or excessive bleeding. The cause of von willebrand disease is a deficiency in or impairment of a protein called von willebrand factor, an important component in your blood-clotting process. In general, it takes longer for people with von willebrand disease to form clots and stop bleeding when they're cut. ...Read more

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What is von willebrand s disease and how serious?

What is von willebrand s disease and how serious?

A bleeding disorder.: It is the most common inherited bleeding disorder.Type 1 is mild , more symptomat in females with menorrhagia and mucous membrane bleeds DDAVP (desmopressin) , inhaler is effective. Type 3 severe , Joint bleeds in addition. Type 1 clotting protein is decreased but missing in type 3 and defective in type 2 ( several sub types). So the VW factor is to be given by infusion In most types 2 and 3 . ...Read more

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What is von willebrand's disease? What is the cure?

Bleeding disorder: This is relatively common hereditary bleeding disorder,the bleeding episodes can be corrected transiently by infusion of fresh or fresh-frozen plasma or cryoprecipitate. ...Read more

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What is von willebrand disease?

What is von willebrand disease?

Bleeding disorder: Vwd is the most common inherited bleeding disorder. Von wiilebrand factor is a clotting protein that helps stabilize clots by helping to bind platelets together and also helps carry factor viii in the blood. In vwd, vw factor is either decreased or does not function appropriately. Clots will form but they are not stable, can easily fall apart/ dissolve, and bleeding will then occur. ...Read more

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What's the von willebrand's ddavp (desmopressin) test?

What's the von willebrand's ddavp (desmopressin) test?

Stimulaton test: Patients with type 1 VWD less vw factor than normal people. However, they store vwf normally in the cells that line their blood vessels. This can be released into the blood by certain drugs; one of these is ddavp (desmopressin). In a DDAVP (desmopressin) challenge the vwf level is measured, a dose of DDAVP (desmopressin) is given, and the level measured again to see if it goes up significantly. If so, DDAVP (desmopressin) can be used to control bleeding. ...Read more

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What is type 3 von willebrand's disorder?

What is type 3 von willebrand's disorder?

Homozygous vWD: Pts with type 3 VWD have loss or mutations of both vwf genes, and produce almost no vwf protein. Clinically they behave like severe hemophilia a patients as their factor viii levels are very low as well, since vwf also carries factor viii in the blood. ...Read more

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What does a low von willebrand factor (vwf) ag: 33 %, low vwf activity: 29 % and factor viii activity: 52 % result mean?

VWD: First of all, these test need to be repeated at least one more time, prederably while you are off all medications. If persistently low, this may mean that you have von willibrand disease (VWD) which is a bleeding disorder. These are several types of VWD and more testing is needed to determine the type. You need to see a hematologist for this. Avoid any surgery and trauma. ...Read more