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Doctor insights on: What Is Von Willebrand

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What is von willebrand disease?

What is von willebrand disease?

Bleeding disorder: Vwd is the most common inherited bleeding disorder. Von wiilebrand factor is a clotting protein that helps stabilize clots by helping to bind platelets together and also helps carry factor viii in the blood. In vwd, vw factor is either decreased or does not function appropriately. Clots will form but they are not stable, can easily fall apart/ dissolve, and bleeding will then occur. ...Read more

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Dr. Joseph Torkildson
49 doctors shared insights

Von Willebrand (Definition)

Von Willebrand disease is caused by a deficiency of von Willebrand factor. Von Willebrand factor helps blood platelets clump together and stick to the blood vessel wall, which is necessary for normal blood clotting. There are several types ...Read more


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What is von willebrand's disease?

What is von willebrand's disease?

Von Willebrand ....: Factor . Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii also promotes clotting. So, vwf deficiency also causes secondary fviii dysfunction. Vwf def has many variants. Severity is variable. Most have type i. ...Read more

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What is von willebrand's disease ?

What is von willebrand's disease ?

A bleeding problem: Platelets stop bleeding by patching holes in blood vessels. von Willebrand factor is the glue that sticks platelets to those holes. If von Willebrand factor is low, or if the structure of VWF is abnormal, it doesn't stick platelets to the sites of bleeding. Most people have nosebleeds, gum bleeding, or bleeding after tooth extraction. There are 4 types of VW disease with different symptoms. ...Read more

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What is von willebrand's disease? What is the cure?

Bleeding disorder: This is relatively common hereditary bleeding disorder,the bleeding episodes can be corrected transiently by infusion of fresh or fresh-frozen plasma or cryoprecipitate. ...Read more

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What is von willebrand s disease and how serious?

What is von willebrand s disease and how serious?

A bleeding disorder.: It is the most common inherited bleeding disorder.Type 1 is mild , more symptomat in females with menorrhagia and mucous membrane bleeds DDAVP (desmopressin) , inhaler is effective. Type 3 severe , Joint bleeds in addition. Type 1 clotting protein is decreased but missing in type 3 and defective in type 2 ( several sub types). So the VW factor is to be given by infusion In most types 2 and 3 . ...Read more

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What is type 3 von willebrand's disorder?

What is type 3 von willebrand's disorder?

Homozygous vWD: Pts with type 3 VWD have loss or mutations of both vwf genes, and produce almost no vwf protein. Clinically they behave like severe hemophilia a patients as their factor viii levels are very low as well, since vwf also carries factor viii in the blood. ...Read more

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What is von willebrand's disease type 3?

What is von willebrand's disease type 3?

VonWillebrand type 3: This is severe von willebrand disease. These people may have a total absence of von willebrand factor, and factor viii levels are often less than 10%. Usually inherited in recessive manner (one affected gene from each parent who may not have symptoms). It is essential to see a pediatric hematologist for this disease. ...Read more

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What is the treatment for von willebrand?

What is the treatment for von willebrand?

Several options: The medicines for stopping or preventing bleeding for patients with von willebrand's disease include DDAVP (desmopressin injection, and stymate nasal spray), Amicar (epsilon aminocaproic acid), tranexamic acid, and von willebrand's factor/factor viii concentrates). Which one one should choose depends on the severity of disease and severity of bleeding. It should be decided by a specialist. ...Read more

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How common is von hippel-lindau disease?

How common is von hippel-lindau disease?

Von Hippel-Lindau: Von hippel-lindau syndrome is an inherited disorder characterized by the formation of tumors and fluid-filled sacs (cysts) in many different parts of the body. Tumors may be either noncancerous or cancerous and usually appear during young adulthood; however, the signs and symptoms of von hippel-lindau syndrome can occur throughout life. ...Read more

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I need to know what is von willebrand's disease?

Bleeding disorder: Von willebrand disease is a condition that can cause extended or excessive bleeding. The cause of von willebrand disease is a deficiency in or impairment of a protein called von willebrand factor, an important component in your blood-clotting process. In general, it takes longer for people with von willebrand disease to form clots and stop bleeding when they're cut. ...Read more

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Is there a genetic basis for von willebrand disease?

Yes: Vwd is an inherited condition. It affects both males and females. If one parent has the most common type, type 1, then each child has a 50% chance of inheriting the disease. ...Read more

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What is the definition or description of: Von Hippel Lindau disease?

What is the definition or description of: Von Hippel Lindau disease?

Angiomatosis: Von Hippel Lindau disease is angiomatosis of retina and cerebellum ,it is associated with an increased incidence of hypernephroma, pheochromocytoma , and epandymoma. ...Read more

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Is von willebrand disease considered risky for women?

Is von willebrand disease considered risky for women?

Not necessarily: "risky" is hard to define. Because menstrual bleeding is one of the more common problems women with VWD have, it is considered "riskier" for women than men. It is very possible to manage menstrual bleeding, as well as bleeding with childbirth very effectively, however. Once that happens, VWD is no riskier for women than it is for men. ...Read more

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What is hemophilia?

What is hemophilia?

Clotting problem: Hemophilia is a hereditary blood disorder in which the person is deficient in one of the body's clotting factors (factor viii for hemophilia a and factor ix for hemophilia b). Therefore the blood does not clot correctly after an injury. Depending on severity, patients with hemophilia bleed and bruise easily and for a longer time. Some may even bleed into their joints, muscles, or brain. ...Read more

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I want to know what is the difference between von willebrand's disease and hemophilia?

I want to know what is the difference between von willebrand's disease and hemophilia?

Different but....: Related. Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii partners with fix to activate fx to ultimately promote clotting. So, while different, fviii & vwf deficiency can have similar presentations. Simplified! ...Read more

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What is the treatment for von hippel-lindau disease?

Von Hippel-Lindau: Von hippel-lindau syndrome is an inherited disorder characterized by the formation of tumors and fluid-filled sacs (cysts) in many different parts of the body. Tumors may be either noncancerous or cancerous and usually appear during young adulthood; however, the signs and symptoms of von hippel-lindau syndrome can occur throughout life. ...Read more

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Is a C-section dangerous for someone with von willebrand disease?

Is a C-section dangerous for someone with von willebrand disease?

Possibly: With vwb, you may be at extra bleeding risk. It depends on the platelet count and the function of your blood clotting. So often your doctors will take special precautions. But anything can happen in surgery and with childbirth so being prepared is the most important thing. That being said, in most patients everything is fine. ...Read more

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What causes von hippel lindau?

What causes von hippel lindau?

Genetic: Von hippel–lindau disease is a genetic condition caused by a mutation of the “von hippel-lindau tumor suppressor” gene on chromosome 3 .It is autosomal dominant. ...Read more