Doctor insights on:
What Is The Treatment For Myloma
Many new options: Therapy for myeloma has evolved from cytotoxic drugs (mp, vad, hcvad) to the immunomodulatory drug (imid) thalidomide. More recent drugs include the imid Lenalidomide (revlimid) (pomalidomide coming...), Bortezomib (velcade), doxil, (liposomal doxorubicin) etc. Many new drugs are on the horizon. Bisphosphonate therapy with zoledronic acid (zometa) is of benefit. Tx has changed from simple to complex and individualized. ...Read moreSee 2 more doctor answers
Myeloma treatment: Agressive therapy would be recommended in young people with myeloma. Treatment will include several cycles of combination of 3 different medication as induction then followed by stem cell collection for future autologous stem cell transplantation that can be done soon after completion of chemotherapy or later in the future as indicated- plus minus maintanance therapy . Discuss further with your md. ...Read more
My grandmother aged 65 she had mutiple myeloma and leoimoma can it be cured?What is the treatment?
Which one is worse?: Leiomyoma sounds like a benign tumor, so it should not cause much of a problem. Multiple myeloma is a cancer inside the bone(bone marrow). There is good treatment for myeloma but it is chronic, long term treatment off and on, most patients can and often live for 5-10 years with this cancer. ...Read moreSee 1 more doctor answer
Medication: Define to me- senior people? Treatment will depend on whether the person is a transplant candidate or not. The age cut off would be 70 year old- but also will depend on the overall condition/other medical problems and preference. If not eligible for tansplant-treatment would be combination of 2 or 3 medications ( biological agent, steroids and plus minus chemo ) mainly then +/- maintainanace. ...Read more
Many: There are many options. One source of updated, risk-stratified treatment are the Mayo Clinic Stratification for Myeloma And Risk-adapted Therapy (mSMART) guidelines: http://www.msmart.org/msmart_mar09_002.htm Treatment depends on disease (MM) and host (patient) characteristics as well as the goals of therapy. ...Read more
If I need treatment now, what are my options for multiple myeloma and how successful are they likely to be?
It depends...: An international team has put together guidelines on when patients with myeloma should be treated. Your cancer doctor should be aware of them. There are many things now which can predict how well you will do with treatment and what type of treatment you should have. Patients live much longer with this disease than a decade ago..Some over 20 years making this a chronic illness in many ways. ...Read moreSee 1 more doctor answer
Has tinospora ever been used to treat multiple myeloma or be used at the same time as other multiple myeloma treatment?
Maybe no data?: Never heard of tinospora until your question. I saw a scattering of mentions on an internet search, but no real data. A recent august 2011 review on tinospora in various conditions (not myeloma) is here: http://www.Lahey.Org/departments_and_locations/departments/cancer_center/ebsco_content/multiple_myeloma.Aspx?Chunkiid=111811. ...Read more
Complex question: It's not just the number, but how they crowd out normal cells, and how much other problems they cause (elevated calcium, sludging, infiltration of bone, etc.) would probably need a special online consult to sort this out better. Without an actual examination, I cannot give specific medical advice on your particular health, ...Read more
"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read moreSee 1 more doctor answer
Do I need to begin treatment immediately or are you going to monitor my multiple myeloma for now? Why?
It depends: Standard of care for mgus is observation. Standard of care for smoldering/asymptomatic (no crab sx) mm is observation. Ecog e3a06 is evaluting Lenalidomide vs. Observation in smm. The reason to treat symptomatic mm include: improve survival, reduce bone fractures, reduce infections, improve blood counts, etc. The intensity and type of treatment are highly variable and actively evolving... ...Read moreSee 1 more doctor answer
Minimal: It us a fairly well tolerated drug. Its main side effect is neuropathy which can menifest as tingling, numbness of the toes and fingers and lead to weakness in the hands if the drug is continued for long time. But it does recover after stopping or change over to once weekly use. ...Read more
Possible: Bortezomib, the proteosome inhibitor is licensed for use in multiple myeloma. It has also been used to treat antibody mediated transplant rejection. One side effect is peripheral neruopathy--about 10% of patients. One can speculate that the same mechanism can cause either a failure to emtpy or some urgency of urination. You would need a formal urodynamic assessment to determine this. ...Read more
What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?
1-2-3: Cancer 1-2-3: 1) diagnosis - myeloma vs. ? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. ...Read moreSee 1 more doctor answer
Resuming treatment for myeloma with rev and dex. Recent dexa scan says I have bones of young adult! Haem insists I have zometa infusions. Why?
More benefit: Zoomed makes the bone harder. Myeloma cells live in the bone marrow next to the bone and they bore into the bone. By replacing a mineral of the bone with Zometa the bone become less tasty to the digesting cells that then feed the myeloma.Dex also can soften bones. So these are good reasons to take Zometa but don't overdo it as too much can make the bone too hard. ...Read more
Mult.Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections.What causes fever?
Fever could be side : Effects of the chemotherapeutic agents and steroids considering there's no blood infection. Tylenol (acetaminophen) should help control the fever. Follow up with your oncologist. God bless you! http://www.Livestrong.Com/article/36171-herbs-cancer/. ...Read moreSee 1 more doctor answer
The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?
Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more
Treatable, incurable: Amyloid/multiple myeloma in general are still incurable diseases. It is treatable and there are many different treatment available for amyloid/multiple myeloma which can prolonged survival. Please discuss further with your oncologist re- treatment options for you. See more at : www.Cancer.Gov or www.Cancer.Net or www.Nccn.Com. ...Read moreSee 2 more doctor answers