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Doctor insights on: What Is The Role Of Tamoxifen In The Treatment Of Breast Cancer

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What is the role of tamoxifen in the treatment of breast cancer?

What is the role of tamoxifen in the treatment of breast cancer?

Anti-estrogen: Tamoxifen is one of the anti-estrogen agents used to treat breast cancer. Cancers that exhibit an estrogen receptor (er positive tumors) are treated in part by blocking the estrogen that act as signals to these tumors to grow. ...Read more

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Dr. Barry Rosen
4,316 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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What are the risks of breast cancer returning within a year of original treatment if taking tamoxifen?

What are the risks of breast cancer returning within a year of original treatment if taking tamoxifen?

Low: Most women do well if their tumor is removed and it is in early stages...With high cure rates of 80-85% for stages 1 and 2.. The chances of return within one year of orginal diagnosis have to be very low, perhaps about 5% in my view. ...Read more

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Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No: This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. ...Read more

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Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Yes!: Tamoxifen is only useful in breast cancers which are estrogen receptor positive(er+). So tamoxifen is of no use if the tumor is er negative. Check your tumor's hormone receptor status and you will have the answer to your question>. ...Read more

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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone. Last year i had early catch stage-1 breast cancer. I next had a lumpectomy and only one treatment of chemotherapy. I was scheduled for four treatments. The side affects

Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone.  Last year i had early catch stage-1 breast cancer.  I next had a lumpectomy and only one treatment of chemotherapy.  I was scheduled for four treatments.  The side affects

If : If your breast cancer was estrogen receptor-negative then you will not benefit from hormonal adjuvant therapy like tamoxifen (actually women who are past their menopause should be on Arimidex (anastrozole) not tamoxifen) either way you will not benefit from those since your mass is estrogen receptor negative. At 67 you should probably still get radiation as you still have a long life ahead of you...Especially with stage 1 cancer. You have to discuss these options with a breast surgeon... ...Read more

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Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer?

Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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1st stage breast cancer was removed in march, had radiation therapy(30day), now taking tamoxifen, but coughing phlegm now, can it be a transfer to lungs?

1st stage breast cancer was removed in march, had radiation therapy(30day), now taking tamoxifen, but coughing phlegm now, can it be a transfer to lungs?

Not likely: It is more likely to have bronchitis or pneumonia in the lungs especially following treatment (radiation) for early breast cancer if you develop a cough with phlegm. Check with your doctor who might have you get a chest x-ray. ...Read more

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My sister (66) is a 9 year breast cancer survivor; took tamoxifin for 5 years, & now in 5th year of femora. Is this normal treatment?

Yes for ER+ cancer: Yes, for early stage er + breast cancer - the therapy would include surgical resection ( mastectomy or lumpectomy followed by radiation) then followed by either chemo followed by or estrogen supression therapy - like tamoxifen, or aromatase inhibitor (ai) . Tamoxifen can be started first then switch to ai ( Femara (letrozole) etc) , or can be started on ai in the very beginning - for postmenopausal women. ...Read more

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Breast cancer, 2 tumors, one 1.4x1.7, the other .5. Biopsy states IDC, ER+, PR- and HER2 neg. Ki67 score 50 Treatment mastectomy, chemo and tamoxifen. What are your thoughs on treatment??? Patient is 32 years old

Breast cancer, 2 tumors, one 1.4x1.7, the other .5.   Biopsy states IDC, ER+, PR- and HER2 neg.  
Ki67 score 50

Treatment mastectomy, chemo and tamoxifen.  

What are your thoughs on treatment???  Patient is 32 years old

Curative: At 32, you have a long life ahead of you. By removing the breast with multiple tumors, you are saving yourself a lot of aggravation. There is nothing to keep a cancer from reoccurring in that breast! You did the right thing. Do not look back. You need to move forward! You are getting good treatment from your Provider! ...Read more

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What could happen if someone took tamoxifen if they didn't have breast cancer?

What could happen if someone took tamoxifen if they didn't have breast cancer?

Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Are there any other alternatives to tamoxifen for breast cancer?

Are there any other alternatives to tamoxifen for breast cancer?

Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read more

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I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

May surprise you but: ...Folks with high risk for breast cancer (without cancer) can take it to reduce their risk. It's not for everybody and should be done under the care of a specialist in the field. Anybody else will get the side effects (hot flashes and increased risk for blood clots and uterine cancer) for no gain at all. ...Read more

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Dr. Barry Rosen
1,365 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more