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Doctor insights on: What Is The Role Of Tamoxifen In The Treatment Of Breast Cancer

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What is the role of tamoxifen in the treatment of breast cancer?

What is the role of tamoxifen in the treatment of breast cancer?

Anti-estrogen: Tamoxifen is one of the anti-estrogen agents used to treat breast cancer. Cancers that exhibit an estrogen receptor (er positive tumors) are treated in part by blocking the estrogen that act as signals to these tumors to grow. ...Read more

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Dr. Barry Rosen
4,344 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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What is the role of estrogen in breast cancer?

What is the role of estrogen in breast cancer?

Stimulates the growt: About 80% of breast cancer are er positive which means that the cancer cells are stimulated to grow by estrogen in the body. Decreasing the estrogen levels with tamoxifen which is an estrogen blocker in premenopausal women and aromatase inhibitors which stop estrogen production in sites other than the ovaries in post menopausal women is an important treatment. ...Read more

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What is the treatment of adenofibroma in the breast?

What is the treatment of adenofibroma in the breast?

Fibroadenoma-benign: A fibroadenoma is a benign, common mass seen in the breast. For a diagnosis, a core needle biopsy is performed in an office setting with local anesthesia. We know that these lesions do not turn into cancer. Once a biopsy is done you have options: monitor the area with imaging or have it surgically removed. ...Read more

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What is the cause and the alternative treatment of phyllodes tumor in left breast?

What is the cause and the alternative treatment of phyllodes tumor in left breast?

One treatment only: that is removal , if left alone will grow massive , they are most of the time low grade locally invasive tumors , but some times they are malignant exact cause is unknown. ...Read more

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What is the incidence of breast cancer in men?

What is the incidence of breast cancer in men?

1 in 1000: Breast cancer is 100 times more common in women than in men. A man's lifetime risk of developing breast cancer is about 1/10 of 1%, or one in 1, 000. Male breast cancer is a rare condition, accounting for only about 1% of all breast cancers. ...Read more

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What is the role of oral contraceptives in the treatment of endometriosis?

What is the role of oral contraceptives in the treatment of endometriosis?

Hormonal treatment: Progesterone in the oral contraceptives will antagonize the effects of estrogen and stunt the growth of endometriosis. Progesterone may modulate the pain response as well. ...Read more

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What are the rates of prostate cancer and breast cancer in the U.S.?

What are the rates of prostate cancer and breast cancer in the U.S.?

Cancer rates: The chance of developing an invasive breast cancer during a woman's lifetime is 1 in 8. The chance of developing prostate cancer is about 1 out of every 7 men. About 80% of men over 80 years hold have prostate cancer. ...Read more

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What is the cancer of prostate? 

What is the cancer of prostate? 

Adenocarcinoma: The most common type of prostate cancer is called adenocarcinoma. It is a malignant tumor of the prostate that can have varying degrees of aggresiveness. The more aggressive the tumor, the more likely it will spread and metastasize. ...Read more

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What is the role of estrogen in testosterone treatment?

What is the role of estrogen in testosterone treatment?

Estrogen and Men: Estrogen will feminize a male physique. It will block Testosterone production. It will help a male grow breasts and soften their stomach. I am not sure why you would want to be on Estrogen. Are you Transgendered? ...Read more

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What is the difference in the various stages of colon cancer?

What is the difference in the various stages of colon cancer?

Survival, but.....: Used to be, the short answer was simply survival risk with stage 1 having the best prognosis and stage IV the worst. While stages 1/2 still have the highest survival rates but improved surgical techniques and chemotherapy and i'd add lifestyle changes, have leveled the playing field greatly. Colon cancer, even advanced is often quite treatable. ...Read more

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Is there a chance of getting cancer in the tissue of the breast reconstruction?

Is there a chance of getting cancer in the tissue of the breast reconstruction?

Usually in skin: Yes there is a chance of cancer in the skin or surrounding areas following breast reconstruction. This can occur regardless of the method of reconstruction and is more reflective of the type of cancer and the treatment. However this should not stop you from considering reconstruction. ...Read more

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What is the meaning of "evaluate the prospect of prostate surgery"?

What is the meaning of "evaluate the prospect of prostate surgery"?

Here are some...: The outlook of a surgery, which is the last resort of care after failing to all conservative treatments, is associated with the stage of the disease & patient's overall health state, in attesting: Doc has never cured anything for anyone, except infection at times, but to help modify something for someone to some degree with/without drugs and/or surgery at a reasonable time in a reasonable way.... ...Read more

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What is the symptoms of the prostate cancer?

What is the symptoms of the prostate cancer?

None early on...: Prostate cancer may not cause signs or symptoms in early stages. Prostate cancer that is more advanced may cause signs and symptoms such as: trouble urinating, decreased force in the stream of urine, blood in the urine, blood in the semen, swelling in the legs, discomfort in the pelvic area, and bone pain. Some risk factors include advanced age and family history. Black men are at greater risk. ...Read more

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What is the main cause of breast cancer?

What is the main cause of breast cancer?

Good Question: But unfortunately there is no one good answer , 99% of breast cancers are in woman only 1% in men , first fundamental woman are exposed repeated assaults by estrogen/progesterone hormonal cycles , men are not. Beside genetic so many factors contribute to the genesis of breast , we all should hope some day we will find exact cure breast cancer , now only alternative is awareness , early detect. ...Read more

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What the role of nsaid in colorectal cancer?

What the role of nsaid in colorectal cancer?

NSAIDs v coloncancer: Many studies have reported a beneficial link between nsaids (non-steroidal anti-inflammatory drugs) especially Aspirin and colon cancer (http://www.Cancer.Org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-prevention). Studies show Aspirin as having strongest protective benefit. However, Aspirin & all nsaids can also cause bleeding as well aggravate kidney function. So talk to ur doc. ...Read more

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What is the genetic recurrence of breast cancer?

What is the genetic recurrence of breast cancer?

10-15% Hereditary: We believe that only 10-15% of breast cancers are hereditary, with the rest being environmental in origin. People w/the hereditary form of breast cancer tend to get diagnosed earlier in life and may get cancer in both breasts. When treated by lumpectomy or (single) mastectomy, it is not uncommon to develop a second, unrelated breast cancer; therefore, many opt for double mastectomies. ...Read more

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What is the role of embolization in treatment of avms?

What is the role of embolization in treatment of avms?

Not usually a cure: Most bran avm embolizations now are performed with a glue like substance injected in to the avm blood vessels through a tiny catheter (like a miniature straw) which then hardens in to a cast (onyx). This can be curative in small avms but in the majority of cases it is used as an adjunct to radiosurgery or open surgery. ...Read more

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What is the treatment for cancer of the adrenal glands?

What is the treatment for cancer of the adrenal glands?

Surgical removal: Whenever possible, adrenal cell carcinoma is removed with an operation. This is feasible if the cancer is limited to the adrenal gland without spread to other parts of the body. If there is spread, or if the tumor is too large to be safely removed with an operation, there are limited chemotherapy options available. ...Read more

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What are the non-genetic causes of breast cancer for the women?

What are the non-genetic causes of breast cancer for the women?

Our Environment: Most cases of breast cancer in the US are unrelated to genetics and are believed to be due to our environment. Breast cancer is a disease of the modern world and is much less common in developing nations. Whether it is a byproduct of what we breathe and/or what we eat, the exact causes are unclear. However, we do see cancer more commonly in women with early menarche, late menopause, etc. ...Read more

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What is done for cancer of the breast with calcifications?

What is done for cancer of the breast with calcifications?

Depends: Calcifications do not change the treatment of cancer. Finding them on a mammogram or other imaging study can lead to the right diagnosis (not always cancer btw). The real treatment depends on what is found on biopsy and other studies. ...Read more

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What is the role of tamoxifen in the treatment of breast cancer?

Anti-estrogen: Tamoxifen is one of the anti-estrogen agents used to treat breast cancer. Cancers that exhibit an estrogen receptor (er positive tumors) are treated in part by blocking the estrogen that act as signals to these tumors to grow. ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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What are the risks of breast cancer returning within a year of original treatment if taking tamoxifen?

Low: Most women do well if their tumor is removed and it is in early stages...With high cure rates of 80-85% for stages 1 and 2.. The chances of return within one year of orginal diagnosis have to be very low, perhaps about 5% in my view. ...Read more

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Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No: This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. ...Read more

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Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Yes: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. It has no role in rx of estrogen (-) breast ca. Furthermore, aromatase inhibitors are an effective alternative to tamoxifen for estrogen (+) breast cancer after menopause. ...Read more

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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone. Last year i had early catch stage-1 breast cancer. I next had a lumpectomy and only one treatment of chemotherapy. I was scheduled for four treatments. The side affects

Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone.  Last year i had early catch stage-1 breast cancer.  I next had a lumpectomy and only one treatment of chemotherapy.  I was scheduled for four treatments.  The side affects

If : If your breast cancer was estrogen receptor-negative then you will not benefit from hormonal adjuvant therapy like tamoxifen (actually women who are past their menopause should be on Arimidex (anastrozole) not tamoxifen) either way you will not benefit from those since your mass is estrogen receptor negative. At 67 you should probably still get radiation as you still have a long life ahead of you...Especially with stage 1 cancer. You have to discuss these options with a breast surgeon... ...Read more

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Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer?

Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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1st stage breast cancer was removed in march, had radiation therapy(30day), now taking tamoxifen, but coughing phlegm now, can it be a transfer to lungs?

1st stage breast cancer was removed in march, had radiation therapy(30day), now taking tamoxifen, but coughing phlegm now, can it be a transfer to lungs?

Not likely: It is more likely to have bronchitis or pneumonia in the lungs especially following treatment (radiation) for early breast cancer if you develop a cough with phlegm. Check with your doctor who might have you get a chest x-ray. ...Read more

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My sister (66) is a 9 year breast cancer survivor; took tamoxifin for 5 years, & now in 5th year of femora. Is this normal treatment?

Yes for ER+ cancer: Yes, for early stage er + breast cancer - the therapy would include surgical resection ( mastectomy or lumpectomy followed by radiation) then followed by either chemo followed by or estrogen supression therapy - like tamoxifen, or aromatase inhibitor (ai) . Tamoxifen can be started first then switch to ai ( Femara (letrozole) etc) , or can be started on ai in the very beginning - for postmenopausal women. ...Read more

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Breast cancer, 2 tumors, one 1.4x1.7, the other .5. Biopsy states IDC, ER+, PR- and HER2 neg. Ki67 score 50 Treatment mastectomy, chemo and tamoxifen. What are your thoughs on treatment??? Patient is 32 years old

Breast cancer, 2 tumors, one 1.4x1.7, the other .5.   Biopsy states IDC, ER+, PR- and HER2 neg.  
Ki67 score 50

Treatment mastectomy, chemo and tamoxifen.  

What are your thoughs on treatment???  Patient is 32 years old

Curative: At 32, you have a long life ahead of you. By removing the breast with multiple tumors, you are saving yourself a lot of aggravation. There is nothing to keep a cancer from reoccurring in that breast! You did the right thing. Do not look back. You need to move forward! You are getting good treatment from your Provider! ...Read more

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What could happen if someone took tamoxifen if they didn't have breast cancer?

What could happen if someone took tamoxifen if they didn't have breast cancer?

Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Are there any other alternatives to tamoxifen for breast cancer?

Are there any other alternatives to tamoxifen for breast cancer?

Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read more

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I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

May surprise you but: ...Folks with high risk for breast cancer (without cancer) can take it to reduce their risk. It's not for everybody and should be done under the care of a specialist in the field. Anybody else will get the side effects (hot flashes and increased risk for blood clots and uterine cancer) for no gain at all. ...Read more

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Dr. Barry Rosen
1,378 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more