Doctor insights on:
What Is The Role Of Tamoxifen In The Treatment Of Breast Cancer
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Stimulates the growt: About 80% of breast cancer are er positive which means that the cancer cells are stimulated to grow by estrogen in the body. Decreasing the estrogen levels with tamoxifen which is an estrogen blocker in premenopausal women and aromatase inhibitors which stop estrogen production in sites other than the ovaries in post menopausal women is an important treatment. ...Read moreSee 1 more doctor answer
Fibroadenoma-benign: A fibroadenoma is a benign, common mass seen in the breast. For a diagnosis, a core needle biopsy is performed in an office setting with local anesthesia. We know that these lesions do not turn into cancer. Once a biopsy is done you have options: monitor the area with imaging or have it surgically removed. ...Read more
One treatment only: that is removal , if left alone will grow massive , they are most of the time low grade locally invasive tumors , but some times they are malignant exact cause is unknown. ...Read more
Survival, but.....: Used to be, the short answer was simply survival risk with stage 1 having the best prognosis and stage IV the worst. While stages 1/2 still have the highest survival rates but improved surgical techniques and chemotherapy and i'd add lifestyle changes, have leveled the playing field greatly. Colon cancer, even advanced is often quite treatable. ...Read more
Usually in skin: Yes there is a chance of cancer in the skin or surrounding areas following breast reconstruction. This can occur regardless of the method of reconstruction and is more reflective of the type of cancer and the treatment. However this should not stop you from considering reconstruction. ...Read moreSee 4 more doctor answers
Here are some...: The outlook of a surgery, which is the last resort of care after failing to all conservative treatments, is associated with the stage of the disease & patient's overall health state, in attesting: Doc has never cured anything for anyone, except infection at times, but to help modify something for someone to some degree with/without drugs and/or surgery at a reasonable time in a reasonable way.... ...Read moreSee 1 more doctor answer
None early on...: Prostate cancer may not cause signs or symptoms in early stages. Prostate cancer that is more advanced may cause signs and symptoms such as: trouble urinating, decreased force in the stream of urine, blood in the urine, blood in the semen, swelling in the legs, discomfort in the pelvic area, and bone pain. Some risk factors include advanced age and family history. Black men are at greater risk. ...Read moreSee 1 more doctor answer
Good Question: But unfortunately there is no one good answer , 99% of breast cancers are in woman only 1% in men , first fundamental woman are exposed repeated assaults by estrogen/progesterone hormonal cycles , men are not. Beside genetic so many factors contribute to the genesis of breast , we all should hope some day we will find exact cure breast cancer , now only alternative is awareness , early detect. ...Read moreSee 1 more doctor answer
NSAIDs v coloncancer: Many studies have reported a beneficial link between nsaids (non-steroidal anti-inflammatory drugs) especially Aspirin and colon cancer (http://www.Cancer.Org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-prevention). Studies show Aspirin as having strongest protective benefit. However, Aspirin & all nsaids can also cause bleeding as well aggravate kidney function. So talk to ur doc. ...Read moreSee 1 more doctor answer
10-15% Hereditary: We believe that only 10-15% of breast cancers are hereditary, with the rest being environmental in origin. People w/the hereditary form of breast cancer tend to get diagnosed earlier in life and may get cancer in both breasts. When treated by lumpectomy or (single) mastectomy, it is not uncommon to develop a second, unrelated breast cancer; therefore, many opt for double mastectomies. ...Read more
Not usually a cure: Most bran avm embolizations now are performed with a glue like substance injected in to the avm blood vessels through a tiny catheter (like a miniature straw) which then hardens in to a cast (onyx). This can be curative in small avms but in the majority of cases it is used as an adjunct to radiosurgery or open surgery. ...Read moreSee 2 more doctor answers
Surgical removal: Whenever possible, adrenal cell carcinoma is removed with an operation. This is feasible if the cancer is limited to the adrenal gland without spread to other parts of the body. If there is spread, or if the tumor is too large to be safely removed with an operation, there are limited chemotherapy options available. ...Read moreSee 1 more doctor answer
Our Environment: Most cases of breast cancer in the US are unrelated to genetics and are believed to be due to our environment. Breast cancer is a disease of the modern world and is much less common in developing nations. Whether it is a byproduct of what we breathe and/or what we eat, the exact causes are unclear. However, we do see cancer more commonly in women with early menarche, late menopause, etc. ...Read moreSee 1 more doctor answer
Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read moreSee 1 more doctor answer
What are the risks of breast cancer returning within a year of original treatment if taking tamoxifen?
Yes: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. It has no role in rx of estrogen (-) breast ca. Furthermore, aromatase inhibitors are an effective alternative to tamoxifen for estrogen (+) breast cancer after menopause. ...Read moreSee 1 more doctor answer
I had a lumpectomy for breast cancer and also had chemotherapy as it was grade 3. Now, the doctors want me to have radiations and take tamoxifen, but i'm fed up with the treatment. What should I do?
Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone. Last year i had early catch stage-1 breast cancer. I next had a lumpectomy and only one treatment of chemotherapy. I was scheduled for four treatments. The side affects
If : If your breast cancer was estrogen receptor-negative then you will not benefit from hormonal adjuvant therapy like tamoxifen (actually women who are past their menopause should be on Arimidex (anastrozole) not tamoxifen) either way you will not benefit from those since your mass is estrogen receptor negative. At 67 you should probably still get radiation as you still have a long life ahead of you...Especially with stage 1 cancer. You have to discuss these options with a breast surgeon... ...Read moreSee 3 more doctor answers
Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read moreSee 1 more doctor answer
Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read moreSee 1 more doctor answer
8 year breast cancer survivor on tamoxifen for 3 years now. Transvaginal ultrasound lining 6mm, appears normal and complex. Treatment?
Uterine lining 6 mm:
Are you post -menopausal? if so 6 mm is a bit on the high side would discuss with gyn endometrial biopsy vs. D&C ( you get more tissue with D&C and can miss a spot since biopsies are usually done blind) or hysterscopic biopsy. Tamoxifen can thicken uterine lining.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558364/ ...Read more
Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?
Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read moreSee 2 more doctor answers
1st stage breast cancer was removed in march, had radiation therapy(30day), now taking tamoxifen, but coughing phlegm now, can it be a transfer to lungs?
My sister (66) is a 9 year breast cancer survivor; took tamoxifin for 5 years, & now in 5th year of femora. Is this normal treatment?
Yes for ER+ cancer: Yes, for early stage er + breast cancer - the therapy would include surgical resection ( mastectomy or lumpectomy followed by radiation) then followed by either chemo followed by or estrogen supression therapy - like tamoxifen, or aromatase inhibitor (ai) . Tamoxifen can be started first then switch to ai ( Femara (letrozole) etc) , or can be started on ai in the very beginning - for postmenopausal women. ...Read more
Breast cancer, 2 tumors, one 1.4x1.7, the other .5. Biopsy states IDC, ER+, PR- and HER2 neg.
Ki67 score 50
Treatment mastectomy, chemo and tamoxifen.
What are your thoughs on treatment??? Patient is 32 years old
Curative: At 32, you have a long life ahead of you. By removing the breast with multiple tumors, you are saving yourself a lot of aggravation. There is nothing to keep a cancer from reoccurring in that breast! You did the right thing. Do not look back. You need to move forward! You are getting good treatment from your Provider! ...Read moreSee 2 more doctor answers
Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more
It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read moreSee 2 more doctor answers
Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read moreSee 2 more doctor answers
This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more
Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more
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