Doctor insights on: What is the relationship between vitamin deficiency and pernicious anemia

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What is the relationship between vitamin deficiency and pernicious anemia?

What is the relationship between vitamin deficiency and pernicious anemia?

It's the cause: Pernicious anemia is caused by vitamin B12 deficiency, which is most commonly caused by lack of intrinsic factor, which is a protein that's made in your stomach. Other causes of low B12 and other vitamin deficiencies can cause a nearly identical anemia, but then they are not called "pernicious" anemia. ...Read more

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Dr. Randy Baker
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Vitamin Deficiency (Definition)

A vitamin deficiency is when the body has low levels of one or more essential vitamins. Deficiencies of different vitamins can lead ...Read more


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Positive mthfr heterozygous after multiple miscarriages, known pernicious anemia, what is the likelihood of having other b vitamin deficiencies?

Positive mthfr heterozygous after multiple miscarriages, known pernicious anemia, what is the likelihood of having other b vitamin deficiencies?

Not more likely but: Pernicious anemia is due to problems absorbing B12 but doesn't interfere with absorbing other vits. Mthfr mutations mean you have trouble converting Folic Acid to the active form, so take l-5-mthf. Genes don't affect absorption of other b vits but due to genetics some require higher amounts of b's than others-your other issues don't mean you're more likely to have this but it's safe to try b complex. ...Read more

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Can pernicious anemia or severe vitamin B12 deficiency cause chronic non-specific duodenitis??

Can pernicious anemia or severe vitamin B12 deficiency cause chronic non-specific duodenitis??

Not clear: No clear evidence for the causal-effect relationship between the two. PA is an autoimmue-mediated destruction of parietal cells in stomach, resuling in impairmnent of B12 absorption. Certainly it is possible that pernicious anemia may co-exist or exacerbate duodenitis via immune process or loss of balance in duodenal fluid, or anemia. But the causal-effect relationship is not well established. ...Read more

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What is a recommended diet for someone with hypothyroidism, hypercortisolism, pernicious anemia, and a vitamin d2 deficiency?

What is a recommended diet for someone with hypothyroidism, hypercortisolism, pernicious anemia, and a vitamin d2 deficiency?

Nutrient dense foods: Eat foods that are nutrient dense (like meat, fish, poultry, eggs, cheese, low starch vegatables and water) avoid foods that are not nutrient dense (like starches and sugars, including fruit)
nutrient dense foods will increase your basal metabolic rate. On the other hand, starches and sugars impair thyroid metabolism via affects on your liver (which helps activate thyroid hormone). ...Read more

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Please what's the difference between pernicious anemia and vitamin B12 deficiency. My iron levels are perfect. I'm getting injections for vitamin b12.

Please what's the difference between pernicious anemia and vitamin B12 deficiency. My iron levels are perfect. I'm getting injections for vitamin b12.

Intrinsic factor: Vitamin B12 is present in meat and animal protein foods. Absorption of B12 occurs in the intestine (ileum) and requires intrinsic factor (IF), made by stomach cells. In pernicious anemia, IF production is deficient, and results in anemia, a reduction in hemoglobin/hematocrit. One can be vitamin B12 deficient without becoming anemic and/or without having deficient IF. Best wishes:) ...Read more

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I have vitamin B12 Deficiency not pernicious anemia. My doctor told me. My reading was 160. What is that number is it 160mcg.

I have vitamin B12 Deficiency not pernicious anemia. My doctor told me. My reading was 160. What is that number is it 160mcg.

It's on your report: The lab report should have a reference value. Sometimes it is reported as nanograms per milliliter (ng/mL), or as picograms per milliliter (pg/mL)
1 picogram is equal to 0.001 nanograms, making the nanogram a larger unit.
when you take b12, the dose is usually in micrograms (mcg)
1 mcg is equal to 1000 nanograms
i had to look up all that, by the way ...Read more

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Hi I have vitamin B12 Deficiency. Doc didn't say pernicious anemia. Everyone said I'm going to get cancers. God im so scared. I've started injections?

Hi I have vitamin B12 Deficiency. Doc didn't say pernicious anemia. Everyone said I'm going to get cancers. God im so scared. I've started injections?

B12 def: Are you vegetarian or vegan, they have B12 issues at times because B12 sources are animal. May also be ileitis or intestinal issues where B12 is absorbed (if not pernicious anemia) or dietary/ age. If you are on injections and you level are adequate (I like above 400) I would not be concerned, don't worry ...Read more

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My doctor has told me I do not have pernicious anemia. I have vitamin B12 Deficiency. Blood test result was 160. So I have mild vitamin B12 Deficiency?

Get a consult: "Mild vitamin B12 deficiency" is like being "a little bit pregnant." It should not happen -- ESPECIALLY if you are, as you say, pregnant. If this happened because you are a vegetarian, reconsider or start supplementing now. Otherwise, you have a right & duty to know what's happening. Your primary care physician didn't communicate answers to you -- a 2nd physician's input is in order. ...Read more

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If I have pernicious anemia (intrinsic factor antibody), what happens if I skip monthly vitamin B12 injection?

U get anemic: Hi, skipping the injections will lead to anemia and other consequences of vitb12 deficiency, when the stores are depleted. Hope this answers the query. ...Read more

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Is pernicious anemia helped by B12 vitamins as well as as B12 injections?

Is pernicious anemia helped by B12 vitamins as well as as B12 injections?

Most true B-12: Deficiencies are due to loss of "intrinsic factor", secreted by the stomach, it aids absorption, so if it is missing pills will not work. Shots of b-12, cyanocobalamine, are bright red, and are used for placebo effect in some instances. Most people have intrinsic factor, normal b-12 levels. ...Read more

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What can cause angular cheilitis besides anemia or vitamin deficiency?

What can cause angular cheilitis besides anemia or vitamin deficiency?

Many things: Classically vitamin B12 or iron deficiency is the text book answer, but in the US today, this type of inflammation is more often caused by topical trauma, such as wind, cosmetics, or mouth pieces used in some sports. Some medicines cause the mouth and lips to become dry, and occasional allergic reactions to meds or foods have been reported. ...Read more

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My 12 yr old boy has brown finger nails and toe nails. Is that a anemia or vitamin deficiency? He's tried a lot.

My 12 yr old boy has brown finger nails and toe nails. Is that a anemia or vitamin deficiency? He's tried a lot.

Brown nails: 5 things come to mind:1)fungal infection 2) zinc deficiency also known as acrodemaritis enteropathica 3) smoking unlikely 4) darier disease (keratosis follicularis) or 5) iodine poisoning. Better to see a good internist or dermatologist or a good podiatrist. Thanks. ...Read more

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Hello doctor, I am having chronic illness from past 5-6 years. Fatigue, difficult to concentrate, vitamin deficiency anemia but normal now, zigzag vision, lack of sleep. All reports are normal CT scan, MRI, thyroid etc. I am taking migraine medication past

Hello doctor, I am having chronic illness from past 5-6 years. Fatigue, difficult to concentrate, vitamin deficiency anemia but normal now, zigzag vision, lack of sleep. All reports are normal CT scan, MRI, thyroid etc. I am taking migraine medication past

See below: Your symptoms may be due to one disease or several diseases. Health Tap is not meant to try and diagnose complicated illnesses with multiple symptoms. Please don't try to diagnose your condition on line, it will only confuse and frighten you. If you want to find out what is wrong you must see a Dr. For a careful medical history and examination.

Good luck. I hope you get well soon. ...Read more

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What is the actual cause of B12 (cyanocobalamin) deficiency in the body in pernicious anemia?

What is the actual cause of B12 (cyanocobalamin) deficiency in the body in pernicious anemia?

No intrinsic factor: B12 in the diet usually binds to intrinsic factor in the stomach and then gets absorbed by the small bowel. In pernicious anemia, there is low or no intrinsic factor being made by the stomach cells. As a result, there is gradual deficit of B12 stores and eventaully as all the B12 is gone the new red blood cell production is affected. ...Read more

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Why MCHC is low in iron deficiency anemia but normal in pernicious anemia?

Why MCHC is low in iron deficiency anemia but normal in pernicious anemia?

MCHC: MCHC=mean corpuscular hemoglobin concentration
This value is a calculated value of hemoglobin per red cell. In iron deficiency the body has difficulty making enough hemoglobin, and the resultant cells are both small and low on hgb. The defect with PA is not with hgb synthesis but with cell replication and nuclear maturation, so the amount of hgb/cell is unaffected. ...Read more

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I have pernicious anemia & iron deficiency anemia (severe) of Unknown origin. My hemoglobin has always been stable (low normal) but has dropped twice?

I have pernicious anemia & iron deficiency anemia (severe) of Unknown origin. My hemoglobin has always been stable (low normal) but has dropped twice?

Pernicious anemia,: How was your pernicious Anemia diagnosed? Are you on B12 injections? Are you receiving Folic acid tabs? If you are not receiving replacement therapy for both, you need to see a blood specialist for eval & treatment.
A far as you Hgb dropping twice, there is a source of blood loss, from your GI tract (stomach or colon). you need EGD & colonoscopy to look for blood loss.
Take care ...Read more

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Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Pernicious anemia: Yes your doctor can run a battery of tests including a cbc, peripheral blood smear, a serum b 12 level, and a reticulocyte count. These usually will help to diagnose the condition. Sometimes methylmalonic acid and homocysteine levels will be drawn to help with the diagnosis. ...Read more

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My blood test confirmed my B12 level was low at 178, is that just a deficiency or considered pernicious anemia? I also have iron deficiency anemia.

My blood test confirmed my B12 level was low at 178, is that just a deficiency or considered pernicious anemia? I also have iron deficiency anemia.

Please do what: Your doc asks you to do. Your B 12 is low. Sublingual tablets of B 12 that melt under the tongue are much better than swallowing B 12 because that has to go through the GI tract and you absorb much less. Peace and good health. ...Read more

Dr. Thomas Namey
1,419 Doctors shared insights

Vitamins And Supplements (Definition)

Vitamins and supplements are compounds that are produced and ...Read more


Pernicious Anemia (Definition)

A decrease in red blood cells when the body can't ...Read more