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Doctor insights on: What Is The Genetic Cause Of Sickle Cell Anemia

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Can you please tell me genetics of sickle cell anemia?

Can you please tell me genetics of sickle cell anemia?

Inherited disease.: Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent. This disease is more common in blacks (people of african heritage). Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other. Those with trait are "carriers" and are often asymptomatic. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Can the basic genetic defect of sickle cell anemia be treated?

Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficult and dangerous procedure that can lead to significant complications and death. This is why it is not routinely used to treat sickle cell anemia. Research is ongoing in attempts to have people with sickle cell anemia make normal blood cells. ...Read more

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Is sickle cell anemia purely a genetic disorder?

Is sickle cell anemia purely a genetic disorder?

I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more

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What type of genetic disorder is sickle cell anemia or trait?

What type of genetic disorder is sickle cell anemia or trait?

Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more

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Sickle cell anemia:is this birth defect only due to genetics?

Sickle cell anemia:is this birth defect only due to genetics?

Yes: It is a defect present from birth, yes. Would i call it a birth defect, no. It is a genetically derived abnormality in the metabolism of hemoglobin that results in sickling of the red cells under some circumstances. As a metabolic disease, it is inherited in a similar fashion to pku or cystic fibrosis. The term birth defect is more appropriate for a kid with malformation of an organ or body part. ...Read more

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Please tell me the cause of sickle cell anemia?

Please tell me the cause of sickle cell anemia?

Stiffened hemoglobin: There is a genetic change that causes an abnormal hemoglobin. This abnormal hemoglobin becomes stiff in certain circumstances, causing the red blood cell to sickle. This causes many symptoms, including anemia, pain, and many other symptoms. ...Read more

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What is the cause of sickle cell anemia in fetus?

What is the cause of sickle cell anemia in fetus?

You may be confused.: Fetuses do not suffer from sickle cell anemia in utero because they have a different type of hemoglobin (fetal) that is unaffected even in individuals destined to have sickle cell disease later in life. Affected fetuses come from affected or carrier parents and sickle cell disease is a genetic condition without cure at present. See a genetic counselor to discuss these issues in detail. ...Read more

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What cause the symptoms of sickle cell anemia?

What cause the symptoms of sickle cell anemia?

Symptoms of SS: The altered shape of the red blood cells causes them to stack up together and clog blood vessels, depriving the tissues of adequate blood supply and oxygen. The tissues then die (infarct) and this causes pain. The red cells also rupture or are eaten by the spleen and cause anemia. The spleen itself will gradually infarct, leaving the patient susceptible to infections. ...Read more

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What causes sickle cell anemia besides malaria?

What causes sickle cell anemia besides malaria?

Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia protects carriers from malaria infections, which could be advantageous in certain parts of the world. Malaria does not cause sickle cell anemia. ...Read more

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Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


Dr. Steven Ginsberg
1,239 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more