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Doctor insights on: What Is The Difference Between Tamoxifen And Femara

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What is the difference between tamoxifen and femara (letrozole)?

What is the difference between tamoxifen and femara (letrozole)?

Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What is the difference between femara (letrozole) and arimidex?

What is the difference between femara (letrozole) and arimidex?

Both interfere with : Estrogen production and are used in treatment of breast cancer where the primary was er+. Side effects are similar, cost is much higher fro Letrozole (femara). It is newer. These are each used only in postmenopausal patients. Tamoxifen around for decades is used in premenopausal. ...Read more

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What is the difference between estrogen and progesterone?

What is the difference between estrogen and progesterone?

Totally different: Progesterone and estrogen are quite distinct steroidal molecules secreted by the ovary as well as other entities in the body. The functions of these hormones are quite distinct. ...Read more

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What's the difference between arimidex and femara (letrozole)?

What's the difference between arimidex and femara (letrozole)?

Different companies: These drugs have different structures but act in the same way. Both are aromatase inhibitors. Arimidex (anastrozole) (generic name anastrazole) and Femara (generic name letrozole) may have different side effects in different women, as well as different costs. They can be used interchangeably. ...Read more

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What is the difference between faslodex (fulvestrant) andfemara?

What is the difference between faslodex (fulvestrant) andfemara?

Subtle: Both are used to treat estrogen positive breast cancers but falsofex tends to be used in those less responsive to my understanding . Maybe the oncologists will have more to add. ...Read more

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What is the difference between estrone and estrodiol?

What is the difference between estrone and estrodiol?

Three Estrogens: Estrone, estradiol, and estriol are the three estrogens. They differ in chemical structure which changes their potency and their site of action. Their site of secretion can be different, and their ratios change according to age. ...Read more

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What is the difference between estrace and estriol?

What is the difference between estrace and estriol?

Potency/strength: Estrace contains estradiol which is the "regular strength" estrogen. Estriol is thought to be weaker and not usually prescribed in US ...Read more

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What is the difference between anti-estrogens and anti-aromatases for breast cancer?

What is the difference between anti-estrogens and anti-aromatases for breast cancer?

"cousin-drugs": Tamoxifen ("anti-estrogen") and aromatase inhibitors (ai) are both used for treating breast cancers that are estrogen-receptor +. Ai's are only suitable after menopause but may be slightly more effective; furthermore, they are not associated with any increased risk of uterine cancer like tamoxifen. ...Read more

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What is the difference between castration and penectomy?

What is the difference between castration and penectomy?

Two different organs: Penectomy, or penile resection is used for controlling advanced ulcerating malignancy of the penis which is a rare Orchiectomy or castration is a form of surgery removing the testis to minimize the expression of male hormone in diseases affected by testosterone such as in advanced prostate cancer. The procedure is also employed in the presence of testicular cancer. ...Read more

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What is the difference between glimeripide and metformin?

What is the difference between glimeripide and metformin?

Different dm meds: They are both for diabetes but they work by different mechanism. Glimepiride makes the pancreas produce more Insulin while metformin prevents the liver from making too much sugar and allow the Insulin to work better. ...Read more

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What is the difference in novedex xt and nolvadex (tamoxifen)?

What is the difference in novedex xt and nolvadex (tamoxifen)?

Novedex vs Nolvadex (tamoxifen): Novedex xt is a product used to increase testosterone & muscle mass; it blocks the conversion of testosterone to estrogen, but apparently does not increase muscle mass.Nolvadex (tamoxifen) is used to treat breast cancer, but it reportedly is used by bodybuilders who use Anabolic steroids to prevent gynecomastia (enlarged breasts due to breast tissue rather than muscle. See following comment. ...Read more

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What are the similarities and differences between tamoxifen and femara (letrozole)?

What are the similarities and differences between tamoxifen and femara (letrozole)?

Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read more

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What is the difference between levonorgestrel and estradiol?

What is the difference between levonorgestrel and estradiol?

Progesterone: Levonorgestrel is a synthetically manufactured progestational agen as opposed to Estradiol which is an estrogen. The combination of the two hormones produces the suppression of ovulation and contraception. ...Read more

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What is the difference between ovulation and fertility?

What is the difference between ovulation and fertility?

Fertility/Eggs: Ovulation comes from the word "ova" or egg and refers to the monthly release of an egg. Fertility refers to the probability of becoming pregnant. If everything is working w/woman and partner physically, then they are likely fertile and an egg can be fertilized when cycle permits. If infertile, pregnancy cannot happen. Hope this helps. ...Read more

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What is the difference between paraxtine and venlaflaxin?

What is the difference between paraxtine and venlaflaxin?

Antidepressants: They are pretty different on the neurotransmitters they affect (serotonin/norepinephrin), half life, molecular structure, side effects (like weight gain, paroxetine causes this more often; etc) and pharmacodynamics. They share some indications and uses (besides obviously as antidepressants) and both are relatively inexpensive. ...Read more

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Is there a difference between Clomid (clomiphene) and femara?

Is there a difference between Clomid (clomiphene) and femara?

Yes: Clomid (clomiphene) is a medication to increase egg production in infertility. Femara is a medication used to attempt to keep breast cancer recurrences from happening. Totally different medications. ...Read more

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What is the difference between anticoagulants and antiaggregants?

What is the difference between anticoagulants and antiaggregants?

Drugs: antiplatelet drugs interfere with platelet aggregation. Anticoagulant drugs interfere with the coagulation cascade. Antithrombotic is a term covering both kinds of clot medication. ...Read more

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What is the difference between ovulation and rupture?

What is the difference between ovulation and rupture?

Not much difference: During ovulation a follicle that is like a small cyst ruptures to release the egg. These are about 20-25mm (one inch). Other cysts that are not follicles or related to ovulation may grow bigger and rupture causing more pain and symptoms. ...Read more

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What is the difference between naproxin and meloxocam?

Different classes: The are both nsaids but from different classes just like penicillin and sulfa are both antibiotics but from different classes. ...Read more