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Doctor insights on: What Is The Difference Between Tamoxifen And Femara

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What is the difference between tamoxifen and femara (letrozole)?

What is the difference between tamoxifen and femara (letrozole)?

Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What are the similarities and differences between tamoxifen and femara (letrozole)?

What are the similarities and differences between tamoxifen and femara (letrozole)?

Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read more

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What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

Treatment options: For stage IV breast cancer- if the cancer progressed after tamoxifen and aromasin- depending on several factors such as how much cancer burder, involvement to visceral organs, overall condition etc- the options would be- faslodex; combination of Aromasin (exemestane) and evorilimus ( based on recent randomized clinical trial) or chemotherapy. Discuss further with your oncologist- which one for your case. ...Read more

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What are some similarities and differences between tamoxefen and femara (letrozole)?

Requires long answer: The answer is too long to fit into 400 characters but there is a nice summary at http://www.Health.Com/health/condition-article/0, 20188924, 00.Html. ...Read more

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What is the difference between femara (letrozole) and arimidex?

What is the difference between femara (letrozole) and arimidex?

Both interfere with : Estrogen production and are used in treatment of breast cancer where the primary was er+. Side effects are similar, cost is much higher fro Letrozole (femara). It is newer. These are each used only in postmenopausal patients. Tamoxifen around for decades is used in premenopausal. ...Read more

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What's the difference between arimidex and femara (letrozole)?

Different companies: These drugs have different structures but act in the same way. Both are aromatase inhibitors. Arimidex (anastrozole) (generic name anastrazole) and Femara (generic name letrozole) may have different side effects in different women, as well as different costs. They can be used interchangeably. ...Read more

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Is there a difference between Clomid (clomiphene) and femara?

Yes: Clomid (clomiphene) is a medication to increase egg production in infertility. Femara is a medication used to attempt to keep breast cancer recurrences from happening. Totally different medications. ...Read more

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What is the difference in nolvadex (tamoxifen) and nolvadex (tamoxifen) d?

What is the difference in nolvadex (tamoxifen) and nolvadex (tamoxifen) d?

Check ingredients: As far as I know there is only one Nolvadex (tamoxifen). The chemical ingredient in it is called Tamoxifen which is an anti-estrogen commonly used to treat breast Cancer. ...Read more

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What is the difference in novedex xt and nolvadex (tamoxifen)?

Novedex vs Nolvadex (tamoxifen): Novedex xt is a product used to increase testosterone & muscle mass; it blocks the conversion of testosterone to estrogen, but apparently does not increase muscle mass.Nolvadex (tamoxifen) is used to treat breast cancer, but it reportedly is used by bodybuilders who use Anabolic steroids to prevent gynecomastia (enlarged breasts due to breast tissue rather than muscle. See following comment. ...Read more