Doctor insights on:
What Is The Difference Between Norepinephrine And Epinephrine
1 extra carbon atom: Epinephrine has 1 more carbon & 2 more hydrogen atoms then norepinephrine. This small difference makes the molecules look different, so they interact differently with receptors, and have different effects. One example: norEpinephrine narrows blood vessels, increasing blood pressure; Epinephrine can narrow some arteries while dilating others, and can raise or lower blood pressure. ...Read more
Both: Are made in the adrenal glands of the body and are released in response to a need for increased energy. The fight or flight phenomenon. The biggest difference is that nor-epi causes more vasoconstriction of blood vessels where epi causes more increase in heart rate and cardiac output through contractility. ...Read more
Synthesis & Locale: Norepinephrine (ne) and Epinephrine (e) are both sympathomimetic catecholamines that are synthesized in the adrenal medulla and terminals of sympathetic neurons. Along the metabolic pathway, ne is synthesized first -- and when an enzyme adds a methyl group, you have epinephrine. Ne is the main catecholamine in peripheral tissue and sympathetic neurons. E is mostly made in the adrenal medulla. ...Read more
May be thyroid: If you are not takin stimulants like caffeine or energy drinks and have a yearly physical with normal blood work then be thankful. It could be hyper active thyroid but you would also have weight loss with anxiety and difficulty sleep along with other symptom. If not seeing a physician for more than a year it may be time ...Read more
Probably the best: Example is acetylcholine, but you can't take it as a medication ...Read more
Assuming: This results are serum levels. Norepinephrine level in pg/ml of 946 are high for an adult patient. Epi level appear normal. Serum levels without any more info like 24 hrs urine collection and ct results plus symptoms do not mean a lot. Patient should calm and supine for 30 minutes before collection. Assuming they are working out you for pheocromocytoma. Talk to your doctor with results. ...Read more
Epinephrine and NE: The adrenals and the CNSGet a more detailed answer ›
Smoking: Yes it can also cause the release of norepheneprine. ...Read more
My 11 year old son has highly elevated levels of norepinephrine and epinephrine. How can we help him?
Yes, since: Acetylcholine is the preganglionic transmitterGet a more detailed answer ›
Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?
Not correct: Serotonin does not deplete other neurotransmitters, but there is a balance especially between Dopamine and serotonin. This balance is dynamic and constantly re-establishing itself. Unless there is damage to neurons (which there can be when abusing certain drugs) neurotransmitter changes would not be permanent. ...Read more
14/male results/ catecholamine norm? Norepinephrine, supine 136.0 pg/ml * epinephrine, <10 pg/ml *dopamine, <10 pg/ml norepinephrine, stand 457.0 pg/ml epinephrine, 14.0 pg/ml dopamine, 16.0 pg/m
Blood work showed supine norepinephrine 183pg/ml, epinephrine 11, dopac 1204, dopa 2339; standing norep 639, epi 121, dopac 1099, dopa 1992, normal?
Catecholamine levels: Not sure why you have done these levels, please provide the context, if elevated they suggest an hyper catecholamine state, adrenal tumor etc. ...Read more
I read that a certain amount of cortisol has to be in the adrenal cortex for norepinephrine to be converted to epinephrine. Can anything substitute?
Catecholamines: E and NE are made in the adrenal medulla. In Addison's, where there is no cortisol circulating, there is higher NE and lower E, presumably due to cortisol effects on the adrenal medulla production of catecholamines. If you have adrenal insufficiency and are taking your hydrocortisone, this should not be an issue. ...Read more
Does low blood pressure cause norepinephrine and epinephrine to be created to raise blood pressure, or am I way off?
How come people use epinephrine for heart attacks, and not norepinephrine? And would one or both be useful for a first aid kit?
Epinephrine: Better increases blood flow to the heart and brain ...Read more
What are norepinephrine and epinephrine's effects on heart rate, blood pressure, vasoconstriction, sensitivity to pain, and heat production.
EPI: It increases heart rate and blood pressure (sometimes dangerously). It causes vasoconstriction. Variable effect on pain but generally increases sensitivity and because it ramps up your metabolism it increases heat production. Follow your docs instructions very carefully and don't freelance. ...Read more
If I listen to really fast music, where does epinephine or norepinephrine get released? In temporal lobe? Wud it cause vasoconstriction in temp lobe?
What is the difference between an allergic reaction and an anaphylactic reaction? Do you need epipen (epinephrine) for both?
Catecholamines: These are both catecholamines, synthesized from the Amino Acid tyrosine. Norepinephrine (ne) acts mainly in an area of your brainstem called the locus coeruleus -- triggering the stress response. Ne is also involved in pain, cognition, mood, emotions, movement and blood pressure. Dopamine is involved in regulating mood, pleasure, delusions, psychosis and drug abuse -- and more. ...Read more
Yes: Primatene mist previously available without a rx was just epinepherine. Overuse was associated with bad side effects like stroke and heart attack. Albuterol has less pronounced effects on the heart so its safer. Primatene has been taken off of the retail market because of the problems. ...Read more
Not much different: Primatene mist previously available without a rx was just inhaled epinephrine. Overuse was associated with bad side effects like stroke and heart attack. Albuterol has less pronounced effects on the heart so its safer. Primatene has been taken off of the retail market because of the problems. Both are bronchodilators. ...Read more
The form it comes in: Adrenaline is the chemical. Racemic epi is epi in an aerosol diluted form to deliver into the lungs to function as a bronchodilator and treats bronchial constriction, like in asthma or after removing an endo tracheal tube after surgery. It is a sympathetic (adrenaline) drug that leads to dilating the bronchial tubes. ...Read more
Since metropolol-beta blocker, blocks adrenaline/norephinephrine would it be ok to still use cymbalta (duloxetine) which increases norephinephrine?
Variables: Metoprolol is only 1 of many different beta blockers with differing side effects and potencies both inside ; outside the brain. The blockade is not complete. If done carefully they can be used together but there must be a careful titration to avoid both lack of benefit and production of side effects. ...Read more
Different meds: These are different forms of the same basic med & provided in different concentrations. Epi (1%) racemic @ 2.5%. There is qualitative differences on their effectiveness in a given patient. ...Read more
Can you tell me about epinephrine inhaler vs albuterol differences and effectiveness comparisons please?
Albuterol: Is more specific to your lungs and less likely to cause cardiac problems ...Read more
Receptors: These three medications are used to support the heart and cardiovascular system ie. blood pressure and heart rate. They are known as sympathomimetics and have a similar response to what you would think of as adrenaline. Each has variable effect on either heart rate, heart function (in terms of strength of 'squeeze') and on blood vessels which would translate to higher blood pressure. ...Read more