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Doctor insights on: What Is The Difference Between Lexapro And Zoloft

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Can I take Lexapro (escitalopram) and Zoloft together?

Can I take Lexapro (escitalopram) and Zoloft together?

Only: Only if your dr prescribed it this way; the only normal situation to do this is because you are decreasing one and increasing the other (cross taper) with the goal of eventually end up with only one. Do not start/stop/mix meds without asking prescribing dr. Good luck. ...Read more

Dr. Heidi Fowler
1,094 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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What is the difference between Zoloft and lexapro (escitalopram)?

What is the difference between Zoloft and lexapro (escitalopram)?

Not much: Both are selective serotonin reuptake inhibitors, or ssris, a fancy way of saying they help your brain hold onto and use more of the serotonin it has. Serotonin is one of the chemicals in your body related to happy things, like food, sex, and sleep (which is why the side effects often affect these issues).
Celexa, prozac, Paxil (paroxetine) are also in class.
Diff comes in personal brain chemistry + med. ...Read more

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What are the differences between Zoloft and lexapro (escitalopram)?

What are the differences between Zoloft and lexapro (escitalopram)?

Different SSRIs: Both belong to the selective serotonin reuptake inhibitor or ssri family, same as the old prozac. Lexapro (escitalopram) works faster, in days, but sometimes makes people more "hyper" or "jumpy." zoloft needs 2-3 weeks to have an effect. It has more weight gain and sexual side effects, but in general is better tolerated. They both can be used for anxiety and/or depression in doses that depend on your sx. ...Read more

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I want to switch back to Lexapro (escitalopram) from zoloft. Is that ok?

I want to switch back to Lexapro (escitalopram) from zoloft. Is that ok?

Generally yes: Obviously you should talk to your prescribing doc, don't switch behind their back. They need to know what you're taking, & may have other options to suggest. But yes, it's usually safe & easy to switch between Lexapro (escitalopram) & zoloft. Note that the dosages (mg) are different. Also, zoloft is available as generic while Lexapro (escitalopram) isn't, so Lexapro (escitalopram) costs more & insurance may not cover it. ...Read more

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Will it be hard switching from 100mg of Zoloft for 6 wks to lexapro (escitalopram)???

Zoloft to Lexapro (escitalopram): Making the change from Zoloft to Lexapro (escitalopram) should not be too difficult as long as it's done under a doctor's supervision. You will essentially reduce the daily dose of Zoloft while you increase the daily dose of Lexapro (escitalopram) as your doctor instructs you. You will continue this titration until you are totally off the Zoloft and only on your final daily dose of Lexapro (escitalopram). The process might take 2-3 weeks. ...Read more

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What are the side effects of switching from Lexapro (escitalopram) to zoloft?

What are the side effects of switching from Lexapro (escitalopram) to zoloft?

None: There should be no side effects caused by the switch per se. Since each person has different sensitivities, you may experience a side effect on zoloft you did not experience on lexapro, (escitalopram) where someone else experiences side effects on Lexapro (escitalopram) but not on zoloft. Usually side effects to these drugs are mild and transitory. Talk to your doctor about any discomfort you experience. ...Read more

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How is Luvox different from Zoloft or lexapro (escitalopram)?

How is Luvox different from Zoloft or lexapro (escitalopram)?

Luvox, Zoloft, (sertraline) and: Lexapro (escitalopram) are all SSRIs. They're all 1st line agents in tx of anxiety and depression. They all work via the same mechanism -- inhibiting re-uptake of serotonin, thus increasing serotonin concentrations. The differences between the meds have to do with subtle differences in half life, serotonin receptors targeted, and slight differences in side effect profiles. Talk with ur doc abt the right med 4u! ...Read more

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Can I take Lexapro (escitalopram) and Zoloft together?

Only: Only if your dr prescribed it this way; the only normal situation to do this is because you are decreasing one and increasing the other (cross taper) with the goal of eventually end up with only one. Do not start/stop/mix meds without asking prescribing dr. Good luck. ...Read more

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20 mg of Lexapro (escitalopram) is equivalent to how much zoloft?

Zoloft vs Lexapro (escitalopram): We really don't have equivalency charts for the antidepressants. By clinical experience, however, I would guess that 20 mg of Lexapro (escitalopram) is roughly equivalent to 100 mg or more of zoloft. Best wishes. ...Read more

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How long does it take to adjust when switching from Lexapro (escitalopram) to zoloft?

How long does it take to adjust when switching from Lexapro (escitalopram) to zoloft?

Not long usually.: If the doses are equivalent then there should not be discontinuance symptoms. If the doses are not equivalent, then you could have recurrence of symptoms or you could have side effects from too high a dosage. 3-7% of the population cannot make the switch easily due to different metabolic rates of these two medications. You need to bring your symtoms to your doctors attention. ...Read more

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What steps should I take from going down of Zoloft 200 mg to Lexapro (escitalopram) 10 mg?

What steps should I take from going down of Zoloft 200 mg to Lexapro (escitalopram) 10 mg?

Dr's job: Doctors diagnose and prescribe. That's the way it ought to work. You provide honest descriptions of what's happening then they make honest, well managed prescriptions. So far our society does not recognize do-it-yourself prescription privileges. Work together and good luck. ...Read more

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I overdosed on 2300 mg of Zoloft, then a day later, I did 2100mg of Zoloft and 140 mg of Lexapro (escitalopram).

I overdosed on 2300 mg of Zoloft, then a day later, I did 2100mg of Zoloft and 140 mg of Lexapro (escitalopram).

Overdoses: You are taking potentially lethal doses of medication. Are you suicidal? Call 911 or go to ER immediately. Call National Suicide Prevention Life Line at 1-800-273-8255. ...Read more

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Cross tapered from Lexapro (escitalopram) to Zoloft 4 weeks ago. Now taking (for 2 1/2 weeks)150 mgs zoloft. When should it kick in. Felt good1daythisweek. Thanku?

Up to 4 weeks: From experience starting or changing an SSRI may tale up to 4 weeks to get the desired result give it a little more time then if not working see your physician. ...Read more

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My dr said I could be off of Zoloft for 24 hours and then start 10mg Lexapro (escitalopram) is that safe been on Zoloft for about 15 years on 100mg since sept.2013?

They r SSRIs: I've switched pts directly from one sari to another--usually no problem--paxil can be a problem discontinuing bit others are usually ok. ...Read more

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My son is being weened off of Zoloft and starting Lexapro. He is taking 50 mg of Zoloft and is supposed to start 5 mg of Lexapro today. Can I give him both medications at the same time? He usually takes the Zoloft before bed and I was wondering if it is s

Medicine changes: It will be fine to transition from one medication to another with an overlap time. You can overlap by removing the Zoloft over a two week time frame while adding the Lexapro (escitalopram) gradually or all at once. It takes several days for the Lexapro (escitalopram) to gear up in the body. Monitor him for tiredness, mood changes and sleep changes. These will go away after the total switch. ...Read more

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Why is Zoloft considered a "stronger" medication than Lexapro (escitalopram) or celexa?

Why is Zoloft considered a "stronger" medication than Lexapro (escitalopram) or celexa?

It's not, really: Zoloft is not really a "stronger" medication than Lexapro (escitalopram) or celexa. All 3 are selective serotonin reuptake inhibitors. They differ a little in the particular receptor sites they affect -- zoloft may block norepinephrine re-uptake a little more than Celexa and Lexapro (escitalopram) do, but not nearly as potently as paroxetine, duloxetine, and some older tricyclics. ...Read more

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I've been taking 20mg of lexapro but my doctor is changing me to 50mg of Zoloft. What is the easiest way to switch over?

Can just switch: Many psychiatrists and others will taper one of the SSRIs down while increasing the dose of the other, in order to avoid the discontinuation syndrome and make sure that the other drug isn't producing more adverse drug reactions. However, I have simply switched people over without any significant problems. It can be done either way. Listen to your doctor and/or pharmacist for advice on this. ...Read more

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What are the side effects of switching from Lexapro (escitalopram) to zoloft, howling do they last.?

What are the side effects of switching from Lexapro (escitalopram) to zoloft, howling do they last.?

Depends: Lexapro (escitalopram) and zoloft are both ssris and have the same side effect profiles, though any individual might have some side effects to one that she didn't have to the other. Most discomfort people experience in switching from one ssri to another is due to discontinuation from the first med, if the second one isn't at a sufficient level to avoid those discontinuation effects. Give it 3 weeks. ...Read more

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I was on 20 mg of lexapro (escitalopram) for 2 years and just quit cold turkey Friday, can I switch to 100 mg Zoloft right away?

Transition: Everyone responds differently to going off ssris, and some people are fine with one and not with another. Both of the meds you are talking about selectively inhibit serotonin, so in essence, you are doing the same thing with one medication as the other, so you are really not going off anything cold turkey. Your doctor who prescribed it should know what is appropriate for you. ...Read more

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I overdosed on 2300 mg of Zoloft, then a day later, I did 2100mg of Zoloft and 140 mg of Lexapro (escitalopram). I've been having hallucinations.

I overdosed on 2300 mg of Zoloft, then a day later, I did 2100mg of Zoloft and 140 mg of Lexapro (escitalopram). I've been having hallucinations.

Find a safe place: Please find someone you trust to help you get to a safe place - or call on your own. The risks are high and I have a feeling that you can feel much better w/ the right treatment. It would include serious therapeutic attention to your learning how to take better care of yourself. Those may not be the best Rx's - so a full eval should be done. I hope you find what you need. Best wishes! ...Read more

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I switched from Zoloft to Lexapro (escitalopram) after a week on zoloft. Can I still count that towards time till I feel benefits or do I have to start over?

I switched from Zoloft to Lexapro (escitalopram) after a week on zoloft. Can I still count that towards time till I feel benefits or do I have to start over?

YES: Basically it takes 4-6 weeks for the medication to reach a steady state peak but improvement may be before that. So yes start over with the lexapro (escitalopram). ...Read more

Dr. Heidi Fowler
1,048 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more