Doctor insights on:
What Is The Difference Between Hypersensitivity And Autoimmunity
Very different: A hypersensitivity is generally what we call an allergic reaction. This is mostly to things you find in the environment, and most of the time is driven by an antibody called ige. An autoimmune disease is usually driven by igg antibody, and what is being attacked is something in the body that the immune system thinks is "foreign" and should be "dealt with" when it shouldn't be.See 1 more doctor answer
Autoimmunity is failure of an organism in recognizing its own constituent parts as self, which allows an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Autoimmunity is often caused by a lack of germ development of a target body and as such the immune response acts against its ...Read more
Very different: Hp is a hypersensitivity reaction usually to some organic material usually mold, but also food particles, bird droppings, pets, grains, etc. Asthma presents with mostly reversible airway obstruction due to exercise, allergens, infections. Both can present with sob, cough, wheezing, but hp can also have fever. Hp usually resolves or kept from turning into fibrosis, once removed from trigger.See 1 more doctor answer
Asthma attack: Asthma attack is an airway disease that involves the air passage thru the airways.Hypersensitivity pneumonitis (hp) involves the actual tissues of the lungs which are beyond the airways. Type of injury is differrent. Asthma attack is an acute reaction. While hp is slower mechanism, and presents with insidious progress. Asthma can also be a slow proccess, when it is poorly controlled.See 1 more doctor answer
What is the difference between hypersensitivity and auto-immune disease, in the context of immunology?
They overlap: Hypersensitivity reactions, in the truest sense, are specific reactions your immune system has to any target (allergic reactions, antibody responses to proteins, immune cell responses to bacteria, etc.). The target could be self (your own body) or non-self (e.g. Bacteria or viruses). So, autoimmune reactions are hypersensitivity reactions, but not all hypersensitivity reactions are autoimmune.
Big difference: Type 1 is mediated by the IgE antibody and responsible for anaphylaxis, hay fever, allerg etc. Allergy skin test can identify these. Type 2 is mediated by IgG or IgM antibody and complement proteins that are "cytotoxic" that ends up killing the target cell. Examples of this are hemolytic anemia, Graves disease, Myasthenia gravis, Rheumatic heart disease, etc. For anemia, a Coombs test is used
Type I is immediate: hypersensitivity reactions, involves IgE with histamine and other mediators release from mast cells, while type II is cytotoxic hypersensitivity reactions involving IgG or IgM bound to cell surface antigens, with subsequent complement (a protein in the blood) fixation, there are also type III and type IV reactions, type I reactions are responsible for immediate allergic symptoms to foods or drugs
What is effected: Asthma is a disease of chronic mid to small airway inflammation, sometimes caused by allergens but not always. Hypersensitivity pneumonitis is inflammation of the lung tissue itself as the result of exposure to allergens (eg birds), it usually resolves when the allergen is removed, although long term exposure can lead to scarring.See 1 more doctor answer
See below: Pmr is an auto immune disease. In auto immune diseases certain types of white blood cells attack your own tissues and cause cell or tissue destruction. Lupus and rheumatoid arthritis are two common examples. In these cases the immune system must be modulated, sometimes with powerful medications.
What's the difference between hypersensitivity and auto-immune disease, in the terms of immunology?
Very different: A hypersensitivity is generally what we call an allergic reaction. This is mostly to things you find in the environment, and most of the time is driven by an antibody called ige. An autoimmune disease is usually driven by igg antibody, and what is being attacked is something in the body that the immune system thinks is "foreign" and should be "dealt with" when it shouldn't be.
Function and target: The immune system should react against substances that harm us, and should tolerate substances that do not harm us. In immunodeficiency, there is a weakness on the immune response. Infectious occur frequently and more severe. In autoimmunity, there is malfunction on the immune response, targetting our own tissues, such as our joints in rheumatoid arthritis. Both processes may occur together.
What's the difference between a delayed hypersensitivity reaction & an allergic one, and are they equally concerning?
Yes: Allergic reaction usually refers to reaction within minutes to very rarely a few hours after the exposure. Disease conditions considered mediated by allergy antibody (ige) include asthma, hay fever, stinging insect reaction etc. Delayed reaction occurs from 24 to 72 hrs after contact with the allergen and is mediated mostly by cells (lymphocytes the commonest condition is contact dermatitis.
Medical/lay terms: Medically speaking, there are 4 major types of hypersensitivity: I is immediate, produces itching, sneezing, anaphylaxis, ii is though an antiboy affecting a tissue, iii is by an antibody bound to a substance, and iv, delayed reaction can cause itching, usually a skin lesion, though not immediate. Allergic reaction is a manifestation of hypersensitivity to a substance when exposed to it.
Had botox last week for migraines. Within 7 hrs, face was cherry red, stinging, and itching. Hypersensitivity or allergic reaction? Any difference?
Type II hypersensitivity: Or cytotoxic reactions, are antibody dependent, IgG or IgM binds to the own body cell surface after being altered by a protein, so the immune system recognizes as non-self (foreign) attacks and destroys the cell by fixing a protein called complement, which in turn forms the Membrane Attack Complex and destroy the cell, the most famous is hemolytic anemias and some auto immune diseases
Pain.: Pain is a complex psychoocial and physical process that has genetic and racial influences. Certain cultures reports more pain to stimuli than others. Early learning plays a role (modeling). In addition after a lot of pain the nervous system can become sensitized to the pain and either increase or decrease the response to it.
Desensitization: Allergen desensitization does not work on all allergies--it is most effective with seasonal allergens, indoor allergens and insect bites. Insect bites from bees, red ants and wasps are treated with allergen desensitization. Allergen desensitization uses small amounts of the allergen the person is allergic to and injects the allergen into the individual's body.
Distension/bloating: Distension --may be pain in the guts, if lower part of guts, then urgency to use no.2 bloating-- may be more gassy but not necessary; may be a abdominal fullness sensation.
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