Doctor insights on:
What Is Nonsecretory Myeloma
Kahler disease is also known as Multiple myeloma. I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) pc population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain. More: http://www.Cancer.Net/cancer-types/multiple-myeloma. ...Read more
Myeloma: Myeloma is cancer of the plasma cells.It is diagnosed through series of blood works, imaging like skeletal bone survey or MRI or pet scan, and a bone marrow biopsy. Signs and symptoms may include anemia ( fatigue, lack of energy etc) , increased serum calcium ( can be presented with confusion, dehydration, increase urination etc), kidney failure (declining renal function), bony pain, fracture, etc. ...Read moreSee 2 more doctor answers
Possibly: The United States government believes there is an association between agent orange that was used in vietnam and a variety of cancers including multiple myeloma. Although there is no conclusive proof of causation there are benefits for veterans exposed to agent orange who develop multiple myeloma. ...Read moreSee 1 more doctor answer
ISS - Greipp et al.: International staging system -- the international staging system (iss) for myeloma was published by the intl myeloma working group in 2005: it is useful for comparing clinical trial , but has limited utility for each individual. Stage i: ?2-microglobulin (?2m) < 3.5 mg/l, Albumin >= 3.5 g/dl stage ii: ?2m < 3.5 & Albumin < 3.5 ; or ?2m 3.5- 5.5 irrespective of serum albumin stage iii: ?2m >= 5.5. ...Read moreSee 1 more doctor answer
Bone marrow disease: Myeloma is a malignant disorder characterized by excessive growth of plasma cells. It can several complications: excess levels of calcium in the blood, kidney failure, nerve damage, weakening of the bones, increased risk of infections (to name a few). ...Read moreSee 1 more doctor answer
Only if fracture +: Not everybody who has myeloma will have fracture when diagnosed. Yes, myeloma will involve the bone and there would be increased risk for fracture- however- just because one has myeloma-it does not mean that it is identical to pain unless you have fracture. And if you do-it depends on your tolerance to pain and how severe the fracture is. Pain is very subjective. Discuss with oncologist. ...Read more
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