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Doctor insights on: What Is Nonsecretory Myeloma

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Dr. Qamar Khan
124 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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What is nonsecretory myeloma?

What is nonsecretory myeloma?

No M-spike MM: Most myeloma cells produce an m protein or a part of it that shows up in the blood or urine. Due to much more effective detection techniques, <5% of myelomas are non-secretory. ...Read more

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What is myeloma?

Bone marrow disease: Myeloma is a malignant disorder characterized by excessive growth of plasma cells. It can several complications: excess levels of calcium in the blood, kidney failure, nerve damage, weakening of the bones, increased risk of infections (to name a few). ...Read more

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What is myeloma?

What is myeloma?

Malignant blood : Disease of plasma cells that make proteins and antibodies. This is a disease that can cause bone issues, anemia, elevated calcium and kidney disease. There are several treatments for the disease, but no true cures. ...Read more

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All info about myeloma?

All info about myeloma?

LLS etc websites: www.lls.org, http://www.Cancer.Gov/cancertopics/types/myeloma, www.Themmrf.Org, http://www.Cancer.Org/cancer/multiplemyeloma/index, http://myelomasociety.Org/membership.Html, http://myeloma.Org.

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How bad is pain in myeloma?

How bad is pain in myeloma?

Only if fracture +: Not everybody who has myeloma will have fracture when diagnosed. Yes, myeloma will involve the bone and there would be increased risk for fracture- however- just because one has myeloma-it does not mean that it is identical to pain unless you have fracture. And if you do-it depends on your tolerance to pain and how severe the fracture is. Pain is very subjective. Discuss with oncologist. ...Read more

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What tests diagnose myeloma?

Tests: You would need to have blood works, a skeletal bone survey/ or MRI of the spine as indicated , and definitely a bone marrow biopsy to diagnose a multiple myeloma. Please discuss further with your hematologist/oncologist. ...Read more

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What are the signs of myeloma?

Myeloma: Myeloma is cancer of the plasma cells.It is diagnosed through series of blood works, imaging like skeletal bone survey or MRI or pet scan, and a bone marrow biopsy. Signs and symptoms may include anemia ( fatigue, lack of energy etc) , increased serum calcium ( can be presented with confusion, dehydration, increase urination etc), kidney failure (declining renal function), bony pain, fracture, etc. ...Read more

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Is plasma cell myeloma hereditary?

Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma. ...Read more

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Wo is at risk for multipule myeloma?

Plasma cell & other: People who have diagnosis of plasma cell disorders- called mgus ( monoclonal gammopathy of unknown significance) would be the one who is at risk for multiple myeloma. Other potential risk factors - include older age, male ( hormone related?), black/african american, exposures to radiation, benzene, and other organic solvents, herbicides, and insecticides and other unknown risk factors. ...Read more

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Is there any chemical that cause myeloma?

Possibly: The United States government believes there is an association between agent orange that was used in vietnam and a variety of cancers including multiple myeloma. Although there is no conclusive proof of causation there are benefits for veterans exposed to agent orange who develop multiple myeloma. ...Read more

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What are the different stages is the myeloma?

ISS - Greipp et al.: International staging system -- the international staging system (iss) for myeloma was published by the intl myeloma working group in 2005: it is useful for comparing clinical trial , but has limited utility for each individual. Stage i: ?2-microglobulin (?2m) < 3.5 mg/l, Albumin >= 3.5 g/dl stage ii: ?2m < 3.5 & Albumin < 3.5 ; or ?2m 3.5- 5.5 irrespective of serum albumin stage iii: ?2m >= 5.5. ...Read more

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My grandma was just diagnosed with myeloma. What is that?

Plasma Cell Cancer: From the National Cancer Institute --> What You Need To Know Aboutâ„¢ - What is Multiple #Myeloma - via @theNCI http://ow.ly/o7CJR #mmsm and Snapshot: http://ow.ly/ungNs ...Read more

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What do you suggest if my grandma was just diagnosed with myeloma?

What do you suggest if my grandma was just diagnosed with myeloma?

Medical Oncologist: She would need to see a medical oncologist or hematologist-oncologist, a doctor who specializes in the treatment of blood cancers. ...Read more

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What increases my risk for developing myeloma if I tried to avoid sun since 19?

Not known: Sun exposure is not related to myeloma and causative factors for this cancer have not been well elucidated. ...Read more

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Does cytoxin cause myeloma?

Not really: Used to treat myeloma and very rarely (in high doses) associated with acute leukemia's. ...Read more

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Is multiple myeloma hereditary?

Rarely: There are a few families where it appears hereditary. Having said this, there are families where more than one individual has the disease and the thought is that this may be due to an environmental cause. ...Read more

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How common is multiple myeloma?

How common is multiple myeloma?

Uncommon: Approximately 1% of all cancers and slightly more than 10 % of blood cancers in the United States. ...Read more

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What is the cause of IgE myeloma?

IgE myeloma rare: Ige myeloma is rare. Dr. Kyle recently reviewed IgD and ige myelomas -- http://www.Ncbi.Nlm.Nih.Gov/pubmed/24133829 the exact cause of myeloma is not well understood. ...Read more

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When was multiple myeloma discovered?

"Multiple Myeloma": just means multiple bone marrow tumors. A simple description like that does not take modern technology (though it would not be picked up early). Indeed, it has been known since ancient times. There have been a lot of discoveries along the way that explains what it is and how it arises. Here's an article on its history: http://www.ncbi.nlm.nih.gov/pubmed/21509678 ...Read more