Doctor insights on:
What Is Mosaiic Trisonomy 13
Ordinary chromosomal traits require a pair of chromosomes to determine the traits. Occasionally, as a mistake in cellular division, there is a tripling of one of the chromosomes. When these occur, they usually cause unpleasant, and sometimes deadly conditions in the inheritor of these traits (e.g. Down's). Many we do not know about as they are ...Read more
How to know if certain people are more likely to get trisomy number 13 patau syndrome than others?
I heard that certain people are more likely to get trisomy number 13 patau syndrome than others, why is that?
Child of older mom: Increasing maternal age increases the risk for chromosome disorders, highlighted by trisomy 21 (down syndrome) but applying to rarer trisomies like the trisomy 13 causing patau syndrome (1 in 8000 births or so). Risks for trisomy increase gradually with maternal age, going from <1 in 2000 under 30 to ~ 1 in 50 over age 40, with age 35 arbitrarily set as high risk (~1 in 200). ...Read moreSee 1 more doctor answer
Chromosome error: Humans have 23 pairs of chromosomes(c) making up our dna.When the egg or sperm form, the (c) pairs are supposed to split up with 1 (c) of each pair going to the egg or sperm.If the 13 (c) does not split & both go into an egg, fertilization will add a 3rd from dad & a trisomy 13 will begin to form. The imbalanced (c) causes malformations, miscarriage or early death. ...Read moreSee 1 more doctor answer
Genetic Mutation: Whenever you make germ cells (sperm and eggs) your body mixes up some of your genetic material and then separates it into discrete packets called chromosomes. You have 23 chromosomes in each germ cell. Sometimes in the process of making germ cells, the mechanism for sorting them out can get rusty (especially with age) and you can end up with an extra copy of number 13 -- t13. ...Read more
Many: There are numerous disorders that can happen with abnormalities of chromosomes 10 and 13. Too many to list here. Trisomy 21 means the person has an extra chromosome 21 and this is more commonly known as Down's syndrome. There are many possible phenotypic findings with this disorder, again too many to list here including physical characteristics, heart , hearing, vision, skeletal, developmental.... ...Read more
Not true: Trisomy 13 (3 copies of chromosome 13 in all your cells) is caused by an error in the way one of your two chromosome 13s move when you make an egg or a sperm. It's called nondisjunction. When it happens, it's no one's fault. Marriage between close relatives, like 1st cousins, is common in many places in the world, and trisomy 13 is just as rare there as it is everywhere else. ...Read more
Lifespan: In my clinical experience of 31 years practicing neonatal medicine, i would have to answer your question with a vague response. This is because each affected child does not necessarily have the same degree of affliction. The literature on this tells us that 99.9% die before a year of age. I have not seen one survive longer than two months, and I have seen many. ...Read more
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