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Doctor insights on: What Is Denosumab

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What are the benefits of having denosumab injections?

What are the benefits of having denosumab injections?

Denosumab: Denosumab is an excellent treatment for persons with a low bone mass and at increased risk of fracture. These fractures occur much more often in folks twice your age so you need to have an extensive workup to find out why you might need a drug to prevent bone loss and actually increase your bone health. ...Read more

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What are considered the benefits of having denosumab injections?

What are considered the benefits of having denosumab injections?

Treat osteoporosis: Denosumab is an antibody that works in a way similar to bisphosponates (like fosamax) to decrease bone turnover and decrease the risk of fractures in people with osteoporosis who have had a previous fracture. Studies suggest that it is more effective than bisphosphonates. In your age group, unless you have severe osteoporosis or a previous fracture, you would not be a candidate for it. ...Read more

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Why does denosumab cause muscle pain?

Why does denosumab cause muscle pain?

Side effect: If it happens within 7 to 10 days, it could be a sign that your calcium level could be low which can occur with this medicine. If this applies to your situation, you may want to have your calcium level checked. ...Read more

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70 yo female w/osteoporosis and family hx of BRCA breast cancer. Ok to Denosumab and Reloxifene therapy together??

70 yo female w/osteoporosis and family hx of BRCA breast cancer. Ok to Denosumab and Reloxifene therapy together??

Yes it is OK: You can take these medicines together. There is no significant interaction or harm. So relax and take them as advised by your doctor. ...Read more

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What are the long-term health affects associated with Prolia injections?

Prolia: Prolia is used for just 2 years and is safe and effective in the vast majority of patients. If you ever feel some symptoms you think might be related to Prolia call your doctor right away. PS: Just for kicks one of my twin granddaughters is Leah so I like the term Pro"Leah". ...Read more

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What are the active ingredients in prolia?

Only one: Hi. The only active ingredient in Prolia is denosumab, a monoclonal antibody that binds a signaling molecule, RANK Ligand (RANKL), that bone forming cells (osteoblasts) secrete that activates bone resorbing cells (osteoclasts). RANKL activates the osteoclasts to break down bone. Denosumab interrupts that, and preserves bone mass and architecture. ...Read more

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Instead of prolia for osteoporisis what else is there to take?

Instead of prolia for osteoporisis what else is there to take?

Many options: Depending on your personal presentation, including your DEXA (bone density) scan results, your the frax® score (a tool developed by who to evaluate fracture risk of patients) and your vit d and ca++ levels, there are other meds such as fosamex, actonel, boniva, reclast, (zoledronic acid) to name a few. Osteoporosis treatment is important, so i recommend discussing with a provider who is educated in it. Good luck. ...Read more

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Is prolia best for osteoporosis?

Is prolia best for osteoporosis?

Maybe: Prolia represents a new category of osteoporosis treatment that is effective and has convenient twice yearly dosing. It appears much more effective than the bisphosphonates and rivals Forteo with much more convenience. It is expensive if not covered by your insurance. Whether it is best for you or not depends on many factors which would require more information about a specific patient. ...Read more

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Is prolia ever administered by IV infusion?

Is prolia ever administered by IV infusion?

No. : Prolia is a subcutaneous injection. There are other osteoporosis treatments, such as reclast, (zoledronic acid) which is given by IV infusion. They treat the same thing but are very different drugs. ...Read more

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Will onj stop once i stopped prolia. I've only had 1 injection?

Will onj stop once i stopped prolia. I've only had 1 injection?

Hard to say: There are no conclusive studies or test that link onj to the ingesting of bisphosphonates. The IV form is another story but this also depends upon the type of mouth surgery you are going to have and the skill level of the surgeon performing the surgery. ...Read more

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Prolia inyection for osteoporosis and side effects?

Prolia inyection for osteoporosis and side effects?

Not much: That is statistically different from placebo, though everything under the sun has been reported it is hard to link it to the drug. The one side effect that is different by about2% is infection, do I would not give it to a compromised person or one who had an acting infection. The debate ove osteonecrosis of the jaw continues on. ...Read more

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I am on Prolia for osteoporosis. Should I also be taking calcium and how much?

I am on Prolia for osteoporosis.  Should I also be taking calcium and how much?

Yes: Even if you take a prescription treatment for postmenopausal osteoporosis, you still have to get enough calcium and vitamin D daily, especially if you are at high risk for fracture. You need both calcium and vitamin D because they help in different ways. Calcium: 1200 mg daily helps keep bones strong & Vitamin D: 800-1000 IU daily enables your body to absorb calcium. ...Read more

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Which is best? Prolia or reclast (zoledronic acid)

Which is best? Prolia or reclast (zoledronic acid)

Talk to your doctor: Those drugs work differently. Both have side effects. Your doctor can assess the potential benefits and risks for you, taking into account your health, including other conditions. If uncertain, consider second opinion from an osteoporosis specialist. ...Read more

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Does Alendronate and Prolia produce the same results? I want to choose just taking only one and my t-score is -2.7.

 Does Alendronate and Prolia produce the same results? I want to choose just taking only one and my t-score is -2.7.

Essentially: There are no good "head to head" trials of the meds so I can not say for sure one does not do slightly better than the other, but the avail studies do not show this. They do work very diff though and some individuals may respond better to one than the other. However, the choice of which to use often has to do with other factors. For example GERD & Barret's Esoph may sway you one way cost another. ...Read more

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I just had my 1st dose of Prolia on 11/20. Just started w/ a tooth problem which needs to be pulled. What are my options?

I just had my 1st dose of Prolia on 11/20. Just started w/ a tooth problem which needs to be pulled. What are my options?

More info needed..: Your prior medical history is crucial in determining the proper course of care. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. The oral surgeon extracting the tooth should consult with your primary physician. Together they will determine the best course of care and manage any complications. ...Read more

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What medication has less side effects prolia or reclast (zoledronic acid)?

What medication has less side effects prolia  or reclast (zoledronic acid)?

Prolia: Both medications are anti-resorptive, meaning they prevent breakdown of your bone. Reclast (zoledronic acid) has been used for longer so has more side-effects that are known. It also can not be used if you have kidney problems. Prolia is an injection every 6 months (vs. 12 months with reclast). Both medications tend to be very well tolerated. ...Read more

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Adrenal Insuf, NO immunity, MANY med iss. Finished Forteo DONT want 2 take Reclast/Prolia. Endo mad at me. But, is there anything else?

Adrenal Insuf, NO immunity, MANY med iss. Finished Forteo DONT want 2 take Reclast/Prolia. Endo mad at me. But, is there anything else?

This is a LOT of: information. I see that you make many submissions on Health Tap. It is important to remember that we can NOT diagnose or make medical / medication recommendations/ treatment on the general Health Education portion of HealthTap. Health Tap Prime or Concierge can be used for that purpose. ...Read more