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What Is Brca1 Gene
Prevent cancer: The brca1 gene is a tumor suppressor gene, a gene involved in decreasing the likeliness of developing cancer. A mutation in this gene can increase the likelihood of certain cancers including breast and ovarian cancers. For more information see: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Is there any risk of immuonmodulation treatment for Crohn's disease in a woman with the brca1 gene?
Jury is out.: There is no solid data on this to my knowledge. There are several potential immunomodulatory treatments ( which probably have their own independent risks ) and they are sometimes used in combination. Reports differ on risk but in general appears to be small and manageable. How this changes with brca1 ? ...Read more
Genetic mutation: Genetic mutation in long arm of chromosome 17 in brca 1 , in 13 brca 2, instead of normal protective proteins which control abnormal growth of cell , repair broken down dna, maintain genetic stability, the abnormal proteins fail to protect, and responsible for 40% inherited breast cancers, 80% of breast & ovarian cancers. ...Read moreSee 1 more doctor answer
Life planning: This is something to discuss closely w/ your MD. Ovarian CA more likely w/ BRCA1 than BRCA2. Women w/ either BRCA have >50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing includes removal of the uterus, ovaries, and fallopian tubes, as well as mastectomy. Good luck. ...Read moreSee 1 more doctor answer
Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more
Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more
About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?
50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
I have a 2.8cm ovarian cyst. I have the brca1 mutated gene. My ca125 blood test came back normal. Could it still be early stage of ovarian cancer?
Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read moreSee 1 more doctor answer
Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read moreSee 1 more doctor answer
Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read moreSee 2 more doctor answers
No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read moreSee 1 more doctor answer
Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read moreSee 2 more doctor answers
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