Top
20
Doctor insights on: What Is Brca1 Gene

Share
1

1
What is the definition or description of: brca1 gene?

What is the definition or description of: brca1 gene?

Prevent cancer: The brca1 gene is a tumor suppressor gene, a gene involved in decreasing the likeliness of developing cancer. A mutation in this gene can increase the likelihood of certain cancers including breast and ovarian cancers. For more information see: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

See 2 more doctor answers

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


2

2
Is there any risk of immuonmodulation treatment for Crohn's disease in a woman with the brca1 gene?

Is there any risk of immuonmodulation treatment for Crohn's disease in a woman with  the brca1 gene?

Jury is out.: There is no solid data on this to my knowledge. There are several potential immunomodulatory treatments ( which probably have their own independent risks ) and they are sometimes used in combination. Reports differ on risk but in general appears to be small and manageable. How this changes with brca1 ? ...Read more

3

3
My mom has the brca1 gene mutation. What is my next step for my sisters?

My mom has the brca1 gene mutation. What is my next step for my sisters?

Get tested: All of your mother's children should be genetically counselled and tested. The same goes for her siblings. ...Read more

Dr. Addagada Rao Dr. Rao
10 doctors agreed:
4

4
Whats cause and effect of brca1 gene on breast cancer?

Dr. Addagada Rao Dr. Rao
10 doctors agreed:
Whats cause and effect of brca1 gene on breast cancer?

Genetic mutation: Genetic mutation in long arm of chromosome 17 in brca 1 , in 13 brca 2, instead of normal protective proteins which control abnormal growth of cell , repair broken down dna, maintain genetic stability, the abnormal proteins fail to protect, and responsible for 40% inherited breast cancers, 80% of breast & ovarian cancers. ...Read more

See 1 more doctor answer
5

5
What kind of mutation is present in the brca1 gene in the breast cancer families?

What kind of mutation is present in the brca1 gene in the breast cancer families?

Loss of function: Brca 1 and 2 genes encode proteins than normally repair our dna. When the genes are mutated, the protein they normally make does not work correctly, leading to loss of the ability to fix other dna mutaions, and development of tumors. ...Read more

See 1 more doctor answer
6

6
Found out I am positive for mutation in brca 1 gene advice needed please?

Found out I am positive for mutation in brca 1 gene advice needed please?

Life planning: This is something to discuss closely w/ your MD. Ovarian CA more likely w/ BRCA1 than BRCA2. Women w/ either BRCA have >50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing includes removal of the uterus, ovaries, and fallopian tubes, as well as mastectomy. Good luck. ...Read more

See 1 more doctor answer
7

7
What percent of women inherit a brca1 or brca2 gene?

What percent of women inherit a brca1 or brca2 gene?

Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more

8

8
Any stats on how many woman have been tested for the brca1 and brca2 gene?

Any stats on how many woman have been tested for the brca1 and brca2 gene?

Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more

9

9
What is my risk for ovarian cancer is I have the brca-1 gene?

What is my risk for ovarian cancer is I have the brca-1 gene?

54 %: Women with a brca1 mutation have a 54% of getting ovarian cancer during their lifetime. This risk can be reduced to less than 5% by having both ovaries removed. ...Read more

See 1 more doctor answer
10

10
About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

See 2 more doctor answers
11

11
I have a 2.8cm ovarian cyst. I have the brca1 mutated gene. My ca125 blood test came back normal. Could it still be early stage of ovarian cancer?

I have a 2.8cm ovarian cyst. I have the brca1 mutated gene. My ca125 blood test came back normal.  Could it still be early stage of ovarian cancer?

Rare: Ovarian cysts are of concern when over 5 cm. If the small cyst is not complex it is usually followed by ultrasound. Ca 125 has no diagnostic implication but is only of value for monitoring. Brca1 suggests the cyts should be followed. ...Read more

See 1 more doctor answer
12

12
Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read more

See 1 more doctor answer
13

13
What does the brca in brca1 stand for?

What does the brca in brca1 stand for?

Breast Cancer: Women w/ 2+ immediate family members w/ a hx of breast/ovarian CA at 50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing. ...Read more

See 4 more doctor answers
14

14
Brca1 and brca2 stands for?

Brca1 and brca2 stands for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

See 1 more doctor answer
15

15
What do brca1 and brca2 stand for?

What do brca1 and brca2 stand for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

See 2 more doctor answers
16

16
How do you perform tests for brca1 or brca2?

How do you perform tests for brca1 or brca2?

Blood test: Usually someone with breast cancer gets tested if there is an unusual family history, though it may be done more often now. Other family members may get genetic counseling and be offered the test as well. ...Read more

See 1 more doctor answer
17

17
Iam brca1 + is estrogn ok to take to help with hormone issues?

Iam brca1 + is estrogn ok to take to help with hormone issues?

BRCA1 and HRT: If you do decide to take hrt, ask if you can take a lower-dose formula ... If you've been diagnosed with breast cancer or have tested positive for a hereditary gene ( brca1 or brca2) and so are at high risk, you shouldn't use hrt. ...Read more

18

18
Do brca1 and brca2 mutations affect men the same way they affect women?

Do brca1 and brca2 mutations affect men the same way they affect women?

No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read more

See 1 more doctor answer
19

19
If a man is found to have brca1 or brca2 mutations, what should his next step be?

If a man is found to have brca1 or brca2 mutations, what should his next step be?

Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read more

See 2 more doctor answers
20

20
Gyno will not let me take HRT due to brca1. Menopause issues suck. What should I do?

Gyno will not let me take HRT due to brca1. Menopause issues suck. What should I do?

Non meds: Some menopausal symptoms, like hot flashes, mood changes, and fatigue, have a perceptual component and can improve with non-drug approaches like acupuncture or hypnotherapy. May sound funky but many of my patients have benefited of those therapies. ...Read more

See 1 more doctor answer
Dr. Hamid Sajjadi
1 doctor shared a insight

Brca1 Gene (Definition)

The brca1 gene is a tumor suppressor gene, a gene involved in decreasing the likeliness of developing cancer. A mutation in this gene can increase the likelihood of certain cancers including breast and ovarian cancers. For ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more