Top
20
Doctor insights on: Anti Transglutaminase Antibody Test

Share
1

1
What is the blood test tissue transglutaminase antibody?

What is the blood test tissue transglutaminase antibody?

Coeliac Disease.: This is a test for the autoantibody to the transglutaminase protein. These are found in coeliac disease. This is a sign, that there is a reaction to transglutaminase protein and its binding with gliadin, a wheat protein, as well as cross reaction with the small intestine. Thus, patients cannot get nutrition from foods containing gliadin, and need a gluten-free diet..

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


2

2
Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Bad fit: Glad you're interested in basic pathology. Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis.

3

3
Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

No: In and of itself , seborrheic dermatitis does not cause any significant immunologic disorders although certain diseases do have an association with seborrheic dermatitis-like rashes such as zinc deficiency syndromes and parkinsonism, for instance.

See 1 more doctor answer
4

4
My 13y/o daughter has type 1 diabetes. She recently had blood work and her tissue transglutaminase antibody IgA came back high at 39, why is this?

My 13y/o daughter has type 1 diabetes. She recently had blood work and her tissue transglutaminase antibody IgA came back high at 39, why is this?

Celiac sprue screen: People with type i diabetes are at extra risk for some of the other autoimmune diseases including gluten enteropathy. What her physician will do this this information remains to be seen -- your daughter's old enough to talk and participate in any decisions such as a possible trial of a gluten-free diet.

6

6
What do my celiac disease tissue transglutaminase test results mean?

What do my celiac disease tissue transglutaminase test results mean?

Depends...: If the test was performed to identify whether you have celiac disease, an unequivocally elevated ttg value is diagnostic for celiac disease. If you are IgA deficient, and the only ttg assayed was iga, you may miss a diagnosis of celiac disease due to a falsely negative result. If you have celiac disease, ttg can be used to assess how compliant you may be with strict dietary gluten avoidance.

7

7
What is the definition or description of: tissue transglutaminase iga?

What is the definition or description of: tissue transglutaminase iga?

Celiac disease : Since 1997, tissue transglutaminase has been recognized to be the autoantigen pathophysiologically recognized by the immune system that leads to celiac disease. Testing IgA antibodies to ttg is a diagnostic marker that for diagnosing celiac disease that is pretty reliable and relatively inexpensive. There can be false pos and false neg, though.

See 1 more doctor answer
8

8
My TISSUE TRANSGLUTAMINASE IGA is <1.23 U/mL, range is <=3.99 U/mL and my IGA is 114 mg/dL range is 70 - 400 mg/dL, what does this indicate ?

My TISSUE TRANSGLUTAMINASE IGA is <1.23 U/mL, range is  <=3.99 U/mL and my IGA is 114 mg/dL range is 70 - 400 mg/dL, what does this indicate ?

Celiac unlikely: Why were these tests done? Do you have any symptoms? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it is unlikely that you have Celiac disease/gluten intolerance. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex.

9

9
What do my celiac disease tissue transglutaminase iga/igg results mean?

What do my celiac disease tissue transglutaminase iga/igg results mean?

Anti-transglutaminas: Antibodies that bind to transglutaminase could indicate the presence of celiac disease. This is a sugggestive test only. Negative testing does not definitively rule-out celiac dz and positive testing does not confirm the diagnosis. An intestinal biopsy would be the most helpful test.

10

10
Tissue transglutaminase IgA resulted in 2.26. Igg resulted in .47. Does that necessarily mean I have celiac disease?

Looked normal: Iga ttg below 19 u is considered normal. Unless you had an IgA deficiency, i wonder why igg ttg was ordered? If you indeed had an IgA deficiency, then even the slightly positive igg titer would warrant hla genetic testing. If the figures provided were in units, then you do not have celiac disease.

11

11
My baby have high sgot191.8u/l, sgpt189.5u/l, GGT 278u/l n birilubin5.2umol/l.He is on antibiotic when do the blood test. Didmy baby have liver disease?

My baby have high sgot191.8u/l, sgpt189.5u/l, GGT 278u/l n birilubin5.2umol/l.He is on antibiotic when do the blood test. Didmy baby have liver disease?

Abnormal liver tests: The numbers you gave show your baby has elevated liver enzymes and high bilirubin level. There are many reasons why these are high. If your baby is on an antibiotic for infection the infection - if serious - could be causing the liver to be inflamed and cause the higher numbers. Your baby's doctors can do other tests to see if the liver is having problems.

12

12
My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture.

13

13
What is the definitive blood test for spinal meningitis. If it's spread to tissue how is it best treated? Can it be treated with oral antibiotics?

What is the definitive blood test for spinal meningitis. If it's spread to tissue how is it best treated? Can it be treated with oral antibiotics?

None/No: There is no blood test that proves meningitis. Lumbar puncture and spinal fluid examination, pcr's and culture are the definitive tests for meningitis. Bacterial meningitis is treated with high dose intravenous antibiotics that have high blood-brain barrier penetration. Meningitis is not treated with oral antibiotics.

See 1 more doctor answer
14

14
Is a antibody nuclear test 1:320 normal?

Is a antibody nuclear test 1:320 normal?

Depends why elevated: This depends on why you have an elevated ANA. It can be there for lots of reasons. Classically we use this to diagnose systemic lupus erythematosus but most people with a positive ANA do not have systemic lupus erythematosus. As a rheumatologist we are asked to see a lot of people with a positive ANA Most of the time we find some other cause. Yours is high but it may not be high for any bad reason

15

15
How's a poliovirus antibody level test performed?

How's a poliovirus antibody level test performed?

Neutralization assay: Poliovirus antibodies are tested via neutralization assay for polio type 1, polio type 2, and polio type 3 separately. Protection to one type of polio does not protect you from the others. One needs to have protective titers to all three types to be "immune".

17

17
What does the herpes antibody test mean if someone is pos.

Virus in the body: If the antibody for HSV (1 or 2) is positive, it means the person was infected with the virus and the virus is in the persons nerves forever, even if there are no outward signs of an infection. The person can pass the virus to her/his contacts even if there is no sore or rash.

18

18
What is HIV antibody test accuracy?

HIV testing: Yes. Of course it is. That is as long as you have allowed enough time to past for your body to produce antibodies against the HIV if you are infected. If you are not infected then if you only test with the HIV antibody test, you must wait six months after exposure for it to be fully reliable and accurate if you test negative. The situation in reality is that no one need wait that long

See 1 more doctor answer
19

19
How does an HIV antibody test work?

HIV testing: All HIV tests used in the U.S. Detect hiv-1, and some tests have been developed that can also detect hiv-2. (hiv-1 is common in the United States; hiv-2 common in parts of africa.) combination tests have been developed that detect HIV antibody and the HIV antigen called the p24 antigen. Levels of p24 antigen are typically high early in the course of infection and is positive earlier.

20

20
What is hepatitis be antibody test?

Envelope: It is an antibody to the hepatitis b envelope protein. It helps physicians characterize hepatitis b infection.

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more