Doctor insights on:
What Is A Serotonin Reuptake Inhibitor
Anti-convulsant: Some drugs that are used to treat seizures are GABA reuptake inhibitors. GABA is an inhibitory neurotransmitter and has an anti-seizure effect. These drugs reduce the reuptake of GABA into neurons and glia thereby increasing the amount of GABA available to interact with GABA receptors. ...Read more
Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more
Neuron junctions.: Synapses are junctions between neurons, or nerve cells. Nerves transmit signals throughout the body, & synapses are gates where chemical signals are transduced to electrical ones. Synapses may be simply described as excitatory or inhibitory, and often depends on the neurotransmitter involved. For example, excitation of the heart and inhibition of the gut are part of the fight or flight response. ...Read more
Could viibryd (vilazodone hydrochloride) potentially help ocd...And is it the strongest ssri ti hit serotonin receptors because of its dual action?
Choices, choices: The options could really drive anyone mad - not to mention an ocd sufferer. Some like it, some don't. Here's an opinion. You can find a wide range - just as you can for the other meds. What fits you is what matters. A link: http://chipur.Com/2011/03/01/viibryd-a-new-antidepressant-but-anything-exciting/ best! ...Read more
Contraindicated: Never use this combination of drugs, because of high risk for dangerous interaction (e.g. acute hypertension and adjunctive effect of the medication). Hope it help. ...Read more
How does strattera (atomoxetine) help for ADHD if it is a norepinephrine reuptake inhibitor , without affecting dopamine ?
Don't know!: If straterra is a norepinephrine reuptake inhibitor it increases the norepinephrine level in the brain. Methylphenidate stimulants, used in adhd work that way. In my opinion, straterra which was initially unsuccessfully marketed as an antidepressant is not a first line choice for adhd. ...Read more
Is luvox (fluvoxamine) the only ssri that is a sigma agonist...And is that why it is better for anxiety..Explain sigma a sigma agonist?
Fluvoxamine is FDA approved for the treatment of Obsessive Compulsive disorder. It would have to be used off-label for anxiety disorders. A sigma receptor is a non-opiod receptor that binds to different drugs. Here is an excellent abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015019/
TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more
Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read moreSee 1 more doctor answer
How does lyrica (pregabalin) work? Is it similiar to narcotic pain medicine? Or similiar to tramadol as norepinephrine and serotonin reuptake inhibitor?
Lyrica (pregabalin): Dear pika89800 lyrica enhances gaba in the brain and suppresses pain at a cortical level, pain has 3 main levels, local, spinal and brain (cortex), it is non narcotic, it is an antiseizure medication and can sometimes help both pain and anxiety the answer is purely for educational purposes, please contact your md. ...Read more
Way too simplistic: Your brain isn't a 4-cylinder Chevy, where 1 circuit controls 1 function. There are dozens of serotonin receptor subtypes organized into 3 subfamilies. The modulation of mood involves a complex and subtle interplay of excitation & inhibition at multiple receptor subtypes. A neurochemist can spend an entire career researching just 1 receptor subtype. ...Read more
What happens if I take Zoloft and a mao inhibitor like marplan, nardil, and parnate (tranylcypromine)?
Contraindicated: Taking a monoamine oxidase inhibitor (maoi), such nardil, marplan, or Parnate (tranylcypromine) with a serotonin selective reuptake inhibitor (ssri) such as zoloft is contraindicated. When taken together they can lead to serotonin syndrome. This potentially deadly syndrome may cause agitation or restlessness, fast heart beat, hallucinations, increased body temperature, loss of coordination, and nausea. Seek help! ...Read more
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