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Doctor insights on: What Is A Paraneoplastic Antibody Panel Supposed To Check For

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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All my paraneoplastic antibody panel came back negative. This is a good thing right?

Yes (?): Yes - they aren't positive. However that does not prove a paraneoplastic syndrome isn't occuring. The available antibody tests are not perfect. Also -- no - it doesn' clarify what the problem (that the test was performed to evaluate) is. ...Read more

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Does Paraneoplastic antibody syndrome blood test through Mayo Clinic is reliable enough?

Does Paraneoplastic antibody syndrome blood test through Mayo Clinic is reliable enough?

Yes: Mayo Clinic Lab is highly reliable, and is one of the best reference labs in the world. ...Read more

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Why would my dr be ordering a paraneoplastic ab panel if he's not looking for cancer. He's doing a bunch of blood work for possible autonomic dysfu?

Why would my dr be ordering a paraneoplastic ab panel if he's not looking for cancer. He's doing a bunch of blood work for possible autonomic dysfu?

D/w your doctor: You should probably ask your doctor the reasons behind the order.
Sometimes, the case are so complicated that possibilities of causes are in wide range and different testings are needed. Since I don't know exactly the case- pick up the phone and ask your doctor. Certain cancer sometimes is associated with different nonspecific symptoms in different body system-paraneoplastic lab is to check on it. ...Read more

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Is the test for paraneoplastic antibodies clinically useful?

Very much so: Some of the most puzzling clinical syndromes are caused by the immune response to tumors that may not be known to be present yet. There's a group of antibodies for which we can now test that will rule the known syndromes in this category in or out. It's not cheap and isn't to be ordered lightly, but it's a standard part of health care. ...Read more

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What are the Paraneoplastic antibodies blood tests? Why negative results can not rull out the syndrome?

What are the Paraneoplastic antibodies blood tests? Why negative results can not rull out the syndrome?

Imperfect tests: Paraneoplastic syndromes are uncommon and the presence or absence of antibodies is only one evidence for making the diagnosis. See this site for more info.

uncohttp://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC3299076 ...Read more

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If my paraneoplastic ab test came back positive does that mean I have an underlying cancer or will get cancer in the near future?

Paraneoplastic: Paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in the body. So, if your panel is positive-depending on the sensitivity and the specificity of the panel- your doctor needs to make sure to look for presence of occult cancer in you. ...Read more

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I have either autoimmune pandysautonomia or paraneoplastic syndrome. My anti striational antibody was positive. I have metastatic thyroid ca. Which?

I have either autoimmune pandysautonomia or paraneoplastic syndrome. My anti striational antibody was positive. I have metastatic thyroid ca. Which?

Complicated: Could be either, and to complicate matters dysautonomia can be cause by a paraneoplastic phenomenon. Either way the primary focus is to first treat the metastqatic thyroid ca and see how the dysautonomia progresses (and hopefully improves). ...Read more

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Why the antibodies test- paraneoplastic syndrome of mayo clinic and Aetna does not approved by the FDA?

Faulty policy: Many insurances consider certain antibody tests for paraneoplastic syndrome screening involving the nervous system experimental and investigational. They base this on various criteria including debt of research & FDA approval. The tests should be considered medically necessary when ordered selectively for evaluating persons with signs & symptoms of specific paraneoplastic syndromes. ...Read more

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If you have an intradural, extramedullary spinal tumor and pituitary tumor that cannot be biopsied, would it be prudent to run paraneoplastic ab test or any other blood test to rule out cancer?

If you have an intradural, extramedullary spinal tumor and pituitary tumor that cannot be biopsied, would it be prudent to run paraneoplastic ab test or any other blood test to rule out cancer?

It's not for that: The vast majority of cancers don't produce paraneoplastic antibodies that show on labs. If you've been told that a tissue diagnosis cannot be obtained on either of your two tumors, please think about getting a second opinion, though it may be true. Whatever happens, you deserve to be fully educated about your illnesses. ...Read more

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Please. Is it true that primary drs can't order auto immune disease panel. The antibodies test. Is it only the specialist can do that?

Please. Is it true that primary drs can't order auto immune disease panel. The antibodies test. Is it only the specialist can do that?

Primary Care: No. It is not true for all physicians. It may be true for yours. We all have our areas of expertise and a good physician will know when they are not the expert. That is why there are specialists. ...Read more

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2011 hepatiites b antibody positive. Last week hepititas panel negative. Are they the same test and why did they come back different?

2011 hepatiites b antibody positive. Last week hepititas panel negative. Are they the same test and why did they come back different?

Can be confusing: Hepatitis blood tests can be confusing, and explaining it takes more space than available here. There is more than one type of Hepatitis B antibody, so we have to be sure we are comparing the same antibody (we must "compare apples to apples"). If talking about HepBs Ab both times, and it went from positive to negative in an uninfected and vaccinated person, then HepB booster vaccines may be given. ...Read more

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Tg= (thyroglobulin) had tg panel 16.0 results, a tg antibody <0.9, a tg by lc-ms/ms, s/p (n/a)! result not dispersed in flowsheet. What does this mean?

Tg= (thyroglobulin) had tg panel 16.0 results, a tg antibody <0.9, a tg by lc-ms/ms, s/p (n/a)! result not dispersed in flowsheet. What does this mean?

While the: Normal range varies from lab to lab, your results are all normal. Why were they drawn in the first place. There are not as important as more conventional thyroid lab such as free T4 and tsh. Check w/your doctor. ...Read more

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I tested negative for hiv with architect combo. But in the result it says only antibodies but not p24 ag. I thought it checks for ag/ab at Sametime. Is it possible to check only for ab with architect?

I tested negative for hiv with architect combo. But in the result it says only antibodies but not p24 ag. I thought it checks for ag/ab at Sametime. Is it possible to check only for ab with architect?

It tests for both: The Architect® combo test checks for both HIV antibody and p24 antigen. If your result is reported as negative, neither antibody nor antigen was detected. I suspect you have misinterpreted the wording of the test result. If in doubt, check with the doctor who ordered the test, or the laboratory where it was done. ...Read more

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What kind of antibody tests are available to check for immunity to hep c?

What kind of antibody tests are available to check for immunity to hep c?

None: There is no such thing as immunity to hcv. Only hep a and b which can be determined by blood work. ...Read more

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Does architecture HIV combo check for hiv2 group A and B antibodies?

Does architecture HIV combo check for hiv2 group A and B antibodies?

Yes it does: The ARCHITECT HIV Ag/Ab Combo assay is a chemiluminescent microparticle immunoassay (CMIA) for the simultaneous qualitative detection of HIV p24 antigen and antibodies to HIV type 1 (M and group O) and/or type 2 (HIV-2) in human serum and plasma.

This assay does not distinguish between the detection of HIV-1 p24 antigen, HIV-1 antibody, or HIV-2 antibody...just a positive or negative result. ...Read more

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If a doctor checks a pregnant woman's antithyroglobulin antibodies is that normal?

If a doctor checks a pregnant woman's antithyroglobulin antibodies is that normal?

Yes: Low thyroid is very detrimental to the fetus. If you are on thyroid medicine, your levels should be checked during pregnancy. Anti thyroglobulin antibodies just define the source for your thyroid disease as auto immune. Auto immune syndromes may have other manifestations. ...Read more

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Regarding thyroid peroxidase antibodies, if I am positive, should my kids all be checked?

Regarding thyroid peroxidase antibodies, if I am positive, should my kids all be checked?

No.: Anti tpo ab are not inherited directly. If your child develops signs and symptoms of hypothyroidism it might be reasonable to check a tsh, but not tpo. ...Read more

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How much it costs to get baby checked for insulin antibodies?

How much it costs to get baby checked for insulin antibodies?

Depends: It depends on your insurance and its arrangement with the lab you will be using. You will need a doctor to order it (if it is indeed indicated). You certainly don't want to pay the retail price which can be several times that of the negotiated price. ...Read more

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Does anyone when you should get a baby checked for insulin antibodies?

Does anyone when you should get a baby checked for insulin antibodies?

Only with diabetes: In a clinical setting, we only check anti-insulin antibodies in patients presenting with diabetes (type 1 or suspected type 1). ...Read more

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Letter from dr today "antibody in blood which may be significant" isn't in itself anything to worry about, needs checking." should I be worried?

Letter from dr today "antibody in blood which may be significant" isn't in itself anything to worry about, needs checking." should I be worried?

Not necessarily: There are many types of antibodies. Some antibodies are good like igg, igm, and IgA as these are part of the immune system to fight infections. Antibodies can measure a persons response to an infection or immunization. Antibodies that are not helpful are those directed against our own body---called autoantibodies as these may reflect autoimmune disorder. Rather than worry, talk with doc. ...Read more

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When pregnant my older sister had big panel of antibody studies done due to multiple miscarriages. If abnormal, will she have lifelong problem?

When pregnant my older sister had big panel of antibody studies done due to multiple miscarriages. If abnormal, will she have lifelong problem?

Yes: If she has a positive anti-phospholipid antibody, which can cause miscarriages, she may have a life-long propensity to clotting, but this condition may be managed. This positive antibody may occur alone, or in association with other autoimmune cconditions, such as lupus. These conditions can vary widely in their severity. ...Read more

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I had my Hep B surface antibodies checked and they 10 IU/L (3x childhood vaccinations). Am I protected as an adult?

Hepatitis B vaccine: Protection against hepatitis B is believed to be complete even if antibody levels are low or can't even be detected. You could speak to your physician about being revaccinated, but it probably isn't necessary. ...Read more

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IS THERE`S A PRESENT INFECTIOUS? MY EBV ANTIBODY PANEL: VCA - IGM 43 VCA - IGG 1041 EA - IGG 295 EBNA - IGG 133

Yes, it is recent.: Presence of IGM indicates a recent infection. This type of antibody is released early as this carries five times the blocking sites compared to other antibodies. Presence of IGM thus suggests an ongoing attempt by our immune system to fight a current infection. ...Read more