Doctor insights on:
What Induces Apoptosis In Cancer Cells
Many factors.: There are many factors/regulators that induce apoptosis in cancer and normal cells. These are defective or turned off in cancer cells. For example, the x-linked inhibitor of apoptosis protein (xiap) is overexpressed in cancer cells. Xiaps bind to caspase-9, and suppress apoptotic activator cytochrom c, allowing the damaged cells to live. Deactivation of p53 apoptotic protein is another example. ...Read moreSee 1 more doctor answer
If there was an extract that would induce apoptosis/autophagy in cancerous cells and prevent metastasis, would it be beneficial to treating cancers?
Theoretically: Yes substance that would induce programmed cell death would be beneficial, but would need to target only neoplastic cells. ...Read more
Possibly many ways.: This is the active ingredient in chili peppers that causes a burning sensation. It binds to the vanilloid receptor subtype 1 (vr1), which triggers a temperature oriented inflammatory reaction. Some of its effects on cancer are inconclusive, like stomach cancer. It appears to have proposed effects of other cancers, like breast cancer by causing apoptosis by affecting the egfr/her-2 pathway. ...Read moreSee 1 more doctor answer
Do believe the research findings that garlic can cause tumor and cancer cells to undergo apoptosis?
In vitro vs. In vivo: I am unclear about garlic in particular, but let's look at anti-cancer therapy more generally. Many, many (all?) things can kill cancer cells (=apoptosis; there are other modes of cell death, but apoptosis is the most common) in vitro (outside of the body). The predictive ability of in vitro killing to in vivo (in body) effectiveness is not great. ...Read moreSee 1 more doctor answer
Since cancer cells induce cell signaling to increase growth factors in early stages, can that region of cancer be contained and aspirated to survive?
Supply line: Living tissues need blood supply to deliver nutrients and oxygen and to get rid of cellular waste. This is especially true in fast growing malignant cells. It's a bit more complex than that but i don't have much space. Blocking angiogenesis is one of the current therapies used for many cancers. ...Read more
Mutations: Several of the known mutations that contribute to the malignant phenotype work by opposing the normal mechanisms of apoptosis. The discovery of bcl2 mutations driving lymphoma was the first of many. Here's a now-classic paper http://carcin.Oxfordjournals.Org/content/21/3/485.Full. ...Read more
They are immortalize: Programmed cell death is markedly reduced in cancer due to a phenomenon related to prolongation of chromosomal integrity. Normal cell that divide have caps on the top on the tops of their chromosomes known as telomeres. With each division, the telomere is reduced until the cell can not divide any further. Cancer has an enzyme known as telomerase that constantly replace the telomeres. ...Read more
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