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What If Leukemia Returns After Bone Morrow Transplant
Limited treatments: This depends on the type of leukemia and prior treatments but often when leukemia recurs after a bone marrow transplant the treatment options are limited. In many situations the treatment is focused on controlling the leukemia and symptoms since cure is rare at that point. This is something that should be discussed with the transplant physician. ...Read moreSee 1 more doctor answer
In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more
Treatments: If leukemia returns after a bone marrow or stem cell transplant it can still be treated. The type of therapy will be based on many factors such as the type of leukemia, ongoing medical problems, prior therapies used. In some situations additional infusions of donor immune system cells (dli or donor lymphocyte infusions) can be performed. ...Read more
Hopefully cure: CML is a major success story. About 30 years ago up until about 2000, the standard for cure was allogeneic bone marrow transplantation. Now, new drugs can achieve long term remissions of a decade or more. This is the new standard of care but despite this, when these drugs fail, bone marrow transplant is still the gold standard and still the only curative therapy. There are many complications. ...Read moreSee 2 more doctor answers
Balancing act: Certainly one wants to try standard therapy first in most cases because it has less complications. If this approach is unsuccessful or the patient is very high risk, transplant is considered. The decision to go forward is complicated by such things as the patient's performance status, their prior treatments and the amount of disease. These way into the final decision of when it can be helpful. ...Read moreSee 1 more doctor answer
It depends.: The risk of relapse depends on a number of factors, such as whether the patient is in remission, the type of leukemia, and pre-transplant prognostic factors. It also depends upon whether the transplant is autologous (from themselves as donor) or allogeneic (from someone else). The relapse risk can be from modest to almost certain depending on these factors. ...Read moreSee 1 more doctor answer
Any time: We have learned that offering a transplant earlier, when a patient does not respond to therapy or has a relapse is better because there are less complications but at times this may be the only option left. If your doctors and specifically the stem cell transplant team feel this is the best option, they will offer a transplant for your disease. ...Read moreSee 1 more doctor answer
The procedure is not: The actual BM transplant (infusion of cells) is not at all painful. There may be some reactions during infusion such as chills, rigors, fever and others but pain is not common. However, there may be significant discomfort from the effects of chemotherapy and/or radiation that may result in severe mucositis (irritation of the lining of mouth, upper airway and swallowing tube) lasting few weeks. ...Read more
Marrow transplant: Chemotherapy is given first, to try to wipeout as much leukemia as possible from your marrow, then as it is recovering from the chemo, the marrow is infused into your body through the veins, to help you recover faster. Other than the needlestick, there should be very little pain. ...Read more
Highly dependent: On the specific details, but in high risk situations the relapse rate can be as high as 80%. ...Read more
Please give more inf: Depends on many factors including the type of leukemia, age, type of transplant. A more specific question would be easier to give an adequate response. In general allogeneic transplants for AML in remission usually have a leukemia free relapse rate of greater than 50%. ...Read moreSee 2 more doctor answers
Leukemia is a malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
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