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Doctor insights on: What If Ca 125 Doesnt Change After Chemo

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Suzanne Galli
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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What is a good decrease in the ca-125 blood test numbers with chemo?

What is a good decrease in the ca-125 blood test numbers with chemo?

Depends: Best decrease is to normal values, less than 25. A good respond to chemo basically will show normal values that will stay normal. Any elevation of ca 125 after chemo may signal recurrence. ...Read more

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Wife complete debulking for stge 4 ovarian cancer. No l-nodes involved. All cancer removed. Ca125 44 at diagnosis. Ca125 is 3 after 6 rds of chemo. What questions should I ask onc re: prognosis?

Wife complete debulking for stge 4 ovarian cancer.  No l-nodes involved.
All cancer removed. Ca125  44 at diagnosis. Ca125 is 3 after 6 rds of chemo.  What questions should I ask onc re: prognosis?

High Risk: It sounds like she has had a good respons but she is high risk. You need to continue to have her monitored no matter what the numbers show. Her risk of recurrence is high just based on the staging. Her oncologist is the expert in this field. Support gourps may help as well. Good luck. ...Read more

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In stage 4 ovarian cancer, what does it mean if after several chemo treatments, if your ca-125 stays same?

Hard to say: If your ca-125 was very elevated to start with, and it's staying the same, that means the ovarian cancer cells aren't growing, which is good! of course you'd feel better if your ca-125 was going down, but that can take some time. If your ca-125 was in the normal range to start with, or only mildly elevated, it might not be an accurate marker for your cancer. How you feel is very important! ...Read more

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Finished chemo for stage iiia ovarian cancer in oct 2013. Ca125 was 8 6wks ago and 20 now have large right groin node. Is the ca125 jump a lot? Can incisional hernia cause lymph node to swell?

Seek medical exam: Your oncologist needs to know about this groin node if you have not yet told him.Since your ca 125 is still in the normal range, i would not draw any conclusions but your doctor needs to examine you and guide you. It is best not to follow your disease with ca125 right now as it will likely have such fluctuatiosns, causing you to be nervous and anxious, yet it does not help in making treatment decis. ...Read more

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Where does ca125 originate?

In the peritoneal li: It arises from the irritation or growth of peritoneal lining cells. These cells also cover the ovaries. So ca 125 is often used as a test to screening for ovarian cancer. But it often raised in any conditions causing intra -abdominal irritation like in peritonitis. ...Read more

Dr. Devon Webster
945 doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more