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Doctor insights on: What Happens In The Uterus When Estrogen And Progesterone Levels Drop

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In HRT when you have a uterus, do you need to take estrogen & progesterone daily for relief or estrogen first half of cycle progesterone second half?

In HRT when you have a uterus, do you need to take estrogen & progesterone daily for relief or estrogen first half of cycle progesterone second half?

Depends: There are many different ways to prescribe estrogen and Progesterone for treatment of peri-menopausal and menopausal symptoms. Some women take estrogen and Progesterone every day. Others take Progesterone for only 10-15 days out of the month. Others might use Progesterone iud to protect uterus. There's no "right" answer, only what you and your doctor have decided is right for you. ...Read more

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Dr. Seth Derman
1,129 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more


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Does long term use of estrogen and progesterone lower risk for uterine cancer?

Does long term use of estrogen and progesterone lower risk for uterine cancer?

When combined: It will lower risk if combined in an hormone replacement therapy(HRT) for applicable patients. Estrogen used alone for (HRT) in women who still have a uterus present can increase their risk of uterine cancer.(endometrial) when progesterone is not used. ...Read more

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Is slight uterine bleeding normal when you cut back or stop using estrogen/progesterone?

Is slight uterine bleeding  normal when you cut back or stop using estrogen/progesterone?

Maybe.: Bleeding occurs of the amount of progestin is lower than needed by the amount of estrogen. This is why i avoid combo-pills with both in a fixed dose of patch. It is quite controversial about hrt, but Medroxyprogesterone is not "heart healthy, " why estrogen is. Therefore I use natural progesterone. If your bleeding continues, check with your doctor. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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How long can a transfer blastocyst day 5 survive in the uterus? What if it partially implants but progesterone level drops and then rises the next day

How long can a transfer blastocyst day 5 survive in the uterus? What if it partially implants but progesterone level drops and then rises the next day

Progesterone: Progesterone levels fluctuate from day to day and hour to hour until pregnancy is well established - weeks from now. Do not panic about an individual level, what matters to the baby is more-or-less an "average" Progesterone exposure. If you are worried about your progesterone, please discuss these worries with your ivf doctor, he/she is the only one who can make changes if they are needed. ...Read more

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Both my estrogen and progesterone levels are high, why could this be?

Both my estrogen and progesterone levels are high, why could this be?

Cycle: Lets say you are on your period, estrogen and Progesterone levels are going to be at it's lowest levels. On the other hand if you were to be mid cycle or late into your cycle your estrogen and Progesterone are going to be elevated, that is to ovulate and get the endometrium ready for implantation. But if you were early post period at the time of blood sampling that could be abnormal. ...Read more

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What should the ratio be between your estrogen and progesterone levels be after ovulation?

Higher estrogen: You estrogen level in general should be much higher than your Progesterone levels. Normal estrogen levels are about 150-300 and normal Progesterone levels are about 10-25. ...Read more

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What are normal estrogen and progesterone levels for a 37 year old woman?

What are normal estrogen and progesterone levels for a 37 year old woman?

Let me explain: The normal range of estrogen varies depending upon the patient's age. A female aged 30 to 39 will average a level of 210 pg/ml. Progesterone levels vary considerably from cycle to cycle and woman to woman. The middle of the second half of the cycle Progesterone in a non-pregnant patient is 8 to 10, but can be high as 20 ng/ml. ...Read more

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Uterus (Definition)

The uterus is a muscular organ in a woman's pelvis where the the fertilized egg attaches ...Read more


Estrogen (Definition)

Estrogen is a hormone that is secreted by the ovaries and affects ovulation, ...Read more