Doctor insights on:
What Happens In Dysplastic Nevus Syndrome
Close monitoring: Dysplastic nevus syndrome is a condition in which the person has many (often 100's) atypical moles. With the syndrome, one has a higher risk of developing malignant melanoma, which is a high risk skin cancer. For this reason, frequent and close monitoring with self skin checks and routinely by a dermatologist is a must. ...Read moreSee 1 more doctor answer
Many skin cancers: Basal cell nevus syndrome is a rare condition characterized by multiple basal cell carcinomas. These can be large, aggressive and in atypical locations which are not areas of sun exposure. Regular monitoring is essential by a dermatologist or mohs surgeon. ...Read moreSee 2 more doctor answers
No specific link: The congenital melanocytic nevus syndrome is considered sporadic in its occurrence.A few available studies of biopsy material have found abnormalities on the 1st, 12th or 19 th chromosome but no consistent pattern is reported.See the recent article : www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc2994429. ...Read more
Short circuit: Acceesory pathway conduction this pathway may be right or left sided could be antegrade or retrogade in conduction . Tachycardia are symptoms defanitive therappy eps evlation and ablation of tracks for cure very successful in cure .Discuss with an electrophysiologist will help if you are a patient. ...Read more
Genetic: Mh is caused by a muscle abnormality from genetic mutation. When exposed to trigger medications like anesthetics, calcium is released and the muscles become rigid as they break down. There is a rapid rise in body temperature. It is a life threatening complication for anesthesiologists but is treatable if recognized. ...Read more
Please tell me if a lentiginous junctional dysplastic nevus is really melanoma in situ. My doctor won't respond.
There is a subtle di: Melanoma in situ is different than a dysplastic nevus, but it is a continuum. They both need to be treated in the same manner, re-excision with a negative margin.But remember one is a cancer the other one is a precursor of cancer. So it has long term health implications for health insurance etc. ...Read moreSee 1 more doctor answer
See below...: The bone marrow is usually hypercellular (high cellularity) in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated. ...Read moreSee 1 more doctor answer
Glaucoma risk: Pigmentary dispersion is a syndrome where pigment is liberated from the back to the iris due to chaffing and is released into the aqueous humor. The pigment gradually obstructs the drainage apparatus of the eye and in about 30% of the time, may cause enough elevation in the eye pressure to cause glaucoma (pigmentary glaucoma). Its more common in younger myopic males. Treatment is available. ...Read more
What causes turner syndrome, noonan syndrome, & the rare klippel-fell syndrome? What happens during fetal development that causes these conditions?
A genetic accident: During formation of the egg or sperm can leave out an x chromosome in either one. A fetus whose genetic make-up includes the germ cell missing a chr. X has turner syndrome. One of 8 different genetic mutations is passed on to a fetus by 1 parent or happens spontaneously to cause noonan syndrome. 2 related genetic mutations are passed on to the fetus by 1 parent to cause klippel-feil syndrome. ...Read more
What does "atypical intraepidermal melanocytic proliferation, suggestive of melanoma in situ" mean in diagnosis?
How often does dysplastic Nevus turn into melanoma? What percent will actually become malignant? Thanks
Depends on grade: Excisional biopsy of dysplastic nevi with moderate-to-severe and/or severe dysplasia can be of benefit because of the association and potential conversion to malignant melanoma. It is suggested that excision of biopsy-diagnosed DN with mild or moderate dysplasia has less of a benefit with minimal evidence of conversion to invasive melanoma. ...Read more
You have asked...: ...One of the most controversial questions in dermatology. One faction believes that dysplastic nevi are precursors of melanomas, and should be excised before they become melanomas. Another faction believes dysplastic nevi are benign moles that never become melanomas. There is evidence to support both arguments. ...Read moreSee 1 more doctor answer
What does it mean if the drug "rarely causes a serious condition called neuroleptic malignant syndrome" what is that a type of cancer or something?
NMS: Neuroleptic malignant syndrome (nms) is the combination of hyperthermia, rigidity, and autonomic dysregulation that can be a serious complication with antipsychotic medications. Newer atypical antipsychotics can cause this as well as older ones. Dopamine d2 receptor blockade in extrapyramidal pathways, spinal cord, and hypothalamus leads to these symptoms. There can be direct muscle effects too. ...Read more
I had a shave removal that came back as "Lentiginous Junctional (Dysplastic) Nevus with mild atypia, to <0.2 mm OF. Is this of concern?
No: If it is not a melanoma, it is of less concern. Being dysplastic, is a pathologic concerning point, but with it's small size, I would closely watch it. "Mild atypia" is the key to the answer. That is why shave removal's never really remove these, just the top layer. If any increase in size, remove immediately. ...Read more
Is cutaneous squamous cell carcinoma a common malignant tumour in all countries or just with light-skinned peoples?
ABCDE's of moles: Atypical moles that resemble melanoma often has one or all of the following characteristics: a for asymmetry; b for irregular borders; c for lots of different colors (or shades of brown); d for rapidly growing diameter; e for evolving or changing mole. If you have any moles with these characteristics, you should see a dermatologist. ...Read moreSee 1 more doctor answer
Dysplastic nevus, or atypical moles, and they are benign lesions that resemble early melanoma, and about 1 in 10 million americans willmelanoma, what to do?
Watch carefully: Dysplastic nevi are potentially serious in that they can convert to infiltrating melanoma. In children with spitz nevus, they look malignant but never convert. In patients with neurofibromatosis there is a high incidence of dysplastic nevi and since many are present they are watched for changes in shape, darkening in color or redness around the lesion suggesting that they are converting. ...Read more
CAH: Most common is 21 hydroxylase deficiency. Females born with it usually have ambiguous genitalia because a block in adrenal hormone synthesis causes an androgen buildup. Can't tell by looking at a boy. State newborn screening should pick it up right away. Medical emergency to identify as medication is necessary to replace cortisol and aldosterone within a couple of days after birth else crisis. ...Read moreSee 1 more doctor answer