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Doctor insights on: What Happens If You Stop Taking Methotrexate Suddenly

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What happens if you stop taking methotrexate for your arthritis?

What happens if you stop taking methotrexate for your arthritis?

Methotrexate: You will likely have more swelling, pain, & stiffness, unless you are taking another med or dmard. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What happens when you stop taking methotrexate for ra?

What happens when you stop taking methotrexate for ra?

Depends on your RA -: Being controlled or not. Your symptoms might get worse. You should check with your rheumatologists as they might change it for some other medicine or if you are having side effects from the mtx, you may need some meds to counter those effects. ...Read more

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Is it advisable to stop taking methotrexate suddenly for skin diseases?

Is it advisable to stop taking methotrexate suddenly for skin diseases?

possible flare: Possibly may cause flare, but depends on why stopping. If significant side effect, that outweighs the flare risk. ...Read more

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How long does methotrexate stay in your system after you stop taking drug. I am having a allergic reaction to the medicine.

How long does methotrexate stay in your system after you stop taking drug. I am having a allergic reaction to the medicine.

Rapidly leaves: 1/2 life depends on dose 3-10 hours with low dose and 8-15 hours with high dose We usually say it is out after 5 1/2 lives bt there are tissue effects too - maybe 3 weeks ...Read more

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I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?

I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it  will stop?

Could be Crohn's: Some of the most common side effects can be similar to symptoms of crohn's. These include mouth sores, fever, diarrhea, blood in your stools, body aches and abdominal pain. You may want to check with your doctor and make sure this is not a flare up of your disease. ...Read more

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Had irregular cycles prior to taking methotrexate, 2 doses for ectopic. will it make cycle more irregular or cause it to stop permanently?

Had irregular cycles prior to taking methotrexate, 2 doses for ectopic. will it make cycle more irregular or cause it to stop permanently?

May or may not: it may not make you have a normal cycle. This is something you can ask your physician. You may need to do discuss this with the gynecologist. ...Read more

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On methotrexate to control lupus. I can never have children unless i stop this med, but nothing else controls awful symptoms. What are my options?

On methotrexate  to control lupus. I can never have children unless i stop this med, but nothing else controls awful symptoms. What are my options?

Azathioprine or plaq: Plaquenil (hydroxychloroquine) is the safest to be on for pregnancy and in severe lupus we use azathioprine as it not as toxic to a fetus. Talk to your rheumatologist to see what you are a candidate for. ...Read more

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My mom has RA will undergo in this two weeks hip replacment surgery..so she should stop taking adalimumab(humira) and methotrexate for surgery ?

My mom has RA will undergo in this two weeks hip replacment surgery..so she should stop taking adalimumab(humira) and methotrexate for surgery ?

Probably yes: The operating surgeon will direct you in the correct answer. These medicines may change immune system or risk of bleeding, but only the surgeon has the experience to direct your mom for best outcome. When to stoop and restart is crucial to allow the meds to continue controlling the underlying disease. ...Read more

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I have RA and i got small hand deformity am taking methotrexate every saturday and folic acid every sunday.Can that help stop the development?

I have RA and i got small hand deformity am taking methotrexate  every saturday and folic acid every sunday.Can that help stop the development?

Yes, sometimes: Methotrexate is a first line therapy for RA in the us and most other therapies are combined with Methotrexate unless it cannot be used. If inflammation is continuing the addition of a biologic agent (humira, enbrel, (etanercept) simponi) may help prevent longterm damage. They have been shown to provide added benefit. ...Read more

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Why do I need to stop methotrexate & arava (leflunomide) before alif surgery? I can't take it for 2 months after, why?

See details: Two months is an unusually long period to hold Methotrexate after surgery. Three weeks is more the usual but it is ultimately up to your surgeon. ...Read more

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After about how many weeks do you stop noticing improvement with methotrexate 4 arthritis or lupus where max improvement is reached? ~12 weeks?

After about how many weeks do you stop noticing improvement with methotrexate 4 arthritis or lupus  where max improvement is reached? ~12 weeks?

Yes: Three months is reasonable to expect the maximum response to Methotrexate at the specific dose you take. If you still have issues, consider increasing the Methotrexate dose. 25 mg weekly is generally considered to be the maximum weekly dose for the conditions you mention. ...Read more

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Since one year it take 15 mg methotrexate tablet weekly for rheumatoid arthritis so when I can stop it now my blood test is normal but still have pain?

Since one year it take 15 mg methotrexate tablet weekly for rheumatoid arthritis so when I can stop it now my blood test is normal but still have pain?

Which blood test etc: Methotrexate is a good medication for rheumatoid arthritis but it doesn't cure your arthritis - it works as long as you take it. If you still have pain, it may because of active disease (inflammation), or damage that the arthritis has already caused. You should follow up with a rheumatologist if possible. ...Read more

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I was diagnosed with an ovarian ectopic pregnancy. I was given methotrexate to help stop cell division. Will this affect future fertility?

I was diagnosed with an ovarian ectopic pregnancy. I was given methotrexate to help stop cell division. Will this affect future fertility?

No.: You are very fortunate it was caught early and could be treated without surgery. Your chances of pregnancy with two ovaries and fallopian tubes remaining will be normal. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191676/ ...Read more

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I'm on injectable methotrexate and prednisone for Dermatomyositits. I need a tooth pulled and a cleaning. Will I need to stop meds prior?

I'm on injectable methotrexate and prednisone for Dermatomyositits. I need a tooth pulled and a cleaning. Will I need to stop meds prior?

Ask your MD: Dosage and length of time on these meds are important; clotting may be reduced and adrenal glands may be suppressed. Your MD may want to do some blood work prior to an extraction. Should be no problem for a normal cleaning. ...Read more

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Is sulfasalazine good stop gap alternative for stopping methotrexate before fathering a child? N do both these meds have negative effect on t level?

Is sulfasalazine  good stop gap alternative for stopping methotrexate before fathering a child? N do both these meds have negative effect on t level?

Sulfasalazine: Sulfasalazine can be taken safely. There may be lowered sperm counts. Methotrexate carries a risk of birth defects for a child conceived when a parent is actively taking methotrexate. ...Read more

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How to stop hair loss when am on methotrexate for my Ra?

How to stop hair loss when am on methotrexate for my Ra?

Some thoughts: I have seen hundreds of people on Methotrexate for their rheumatoid arthritis and then I agree that hair loss is a bothersome side effects. Nonetheless, at the doses used treat RA I never saw aperson go bald . You're going to have hair loss and there's no good therapy to prevent that. However, some women do notice benefit with using OTC rogaine (minoxidil) in concert with partial hairpieces on social engageme ...Read more

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Can methotrexate fail to stop an ectopic pregnancy from growing, eventually resulting in the rupture of the fallopian tube from the growing pregnancy?

Can methotrexate fail to stop an ectopic pregnancy from growing, eventually resulting in the rupture of the fallopian tube from the growing pregnancy?

Yes it can: Yes this scenario can occur if the ectopic pregnancy is greater than 8 to 10 weeks gestational age as methotrexate is less effective in larger ectopic pregnancies and a surgical approach is the option of choice. ...Read more

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On second antibiotic for UTI. Keflex and now Cipro (ciprofloxacin). Still have symptoms. I am on plaquenil and methotrexate for SLE. Should I temporarily stop meds?

On second antibiotic for UTI. Keflex and now Cipro (ciprofloxacin). Still have symptoms. I am on plaquenil and methotrexate for SLE. Should I temporarily stop meds?

Check with doc first: The bacteria that cause UTI often are resistant to many antibiotics. It is possible but unusual for a UTI to resist both cephalexin (Keflex) and ciprofloxacin, so maybe UTI, maybe not. A vaginal yeast infection triggered by the antibiotics could cause UTI-like symptoms. Don't stop treatment yet, but speak with the doctor who prescribed it about next steps. ...Read more

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What happens if taking methotrexate for autoimmune diseases?

It depends: Methotrexate is a potent immunosuppressive medication . It also helps reduce the need for corticosteroids that have significant side effects. Its major side effect is on the liver, causing liver damage; it can affect the lining of the gut; rarely it causes a hypersensitivity inflammation of the lung (Methotrexate pneumonitis). Therefore, patients need to be carefully monitored while on the drug, . ...Read more

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Dr. Robert Lowe
337 doctors shared insights

Rheumatrex (Definition)

Rheumatrex ...Read more