Doctor insights on:
What Happens If You Stop Taking Methotrexate For Juvenile Rheumatoid Arthritis
Comes back: Rarely does RA go into true remission without getting worse after stopping the immunosuppressives. This is particuarly true for methotrexate. Many people have stopped gold therapy without a return of the arthritis for many years. Occasionally biologics can be stopped after several years of remission but the RA usually returns. ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
See below: He/she may experience a flare in his/her symptoms. Let the doctor know what's going on. ...Read more
See below: If you are in remission on medication for Rheumatoid Arthritis, under a doctor,s supervision and in remission long enough he may guide you to discontinue. Otherwise, you should never attempt on your own because it can recur worse than ever and the drugs that once worked may not if started again. This disease can damage your joints. ...Read more
It depends: Methotrexate is a potent immunosuppressive medication . It also helps reduce the need for corticosteroids that have significant side effects. Its major side effect is on the liver, causing liver damage; it can affect the lining of the gut; rarely it causes a hypersensitivity inflammation of the lung (Methotrexate pneumonitis). Therefore, patients need to be carefully monitored while on the drug, . ...Read moreSee 1 more doctor answer
A disaster: You will likely develop progressive joint damage, deformity and disability. This process starts often very early in the disease course. Do not risk it. ...Read more
Shorter life: Untreated rheumatoid arthritis shortens lives. The effect on the lifespan depends on the severity of the disease and the amount of inflammation. Rheumatoid arthritis commonly causes joint deformities which, if they occur, can only be reversed by surgery. It is best to get prompt diagnosis and treatment. Ra is serious chronic disease like diabetes. ...Read more
MTX & TNF-inhibitor: Kids tolerate the combination of weekly Methotrexate injected under the skin(mtx)and a tnf-inhibitor(enbrel, humira, (adalimumab) remicade)so well, there is no reason to not start both medications.The goal in children should be no active arthritis.There is not the same risk of infections that adults have w/ meds.Kids are growing and anything less than total remission of their disease can inhibit normal growth. ...Read moreSee 1 more doctor answer
See details: The two major DMARDs for treating psoriatic arthritis are Methotrexate and the biologics such as Remicade, (infliximab) Enbrel and Humira among others. All are extremely effective, especially the biologics. All have potential side effects such as infection risk, reduced blood counts and liver disease. ...Read more
Depends on your RA -: Being controlled or not. Your symptoms might get worse. You should check with your rheumatologists as they might change it for some other medicine or if you are having side effects from the mtx, you may need some meds to counter those effects. ...Read more
I started taking lefluomide for rhematoid arthritis for about 3 mos. The precautions concern me. Can i stop taking this immediately or gradually?
Talk to doc.: Can stop immediately, but... I am sure you are taking this medication for a very good reason and have not done well on some of the other meds. I am sure you are being monitored by a rheumatologist. Before stopping this med you should sincerely consider the return of your underlying disease and discuss with your doctor. ...Read moreSee 1 more doctor answer
Many!: Methotrexate, sulfasalazine, hydroxychloroquine, doxycycline, minocycline, cyclophosphamide, azothioprine and more! then, you have the tnf-alpha drugs: humira, remicade, enbrel, cimzia, and more. Then other biologics: Rituxan and orencia (abatacept). New drugs will shortly be online as well! ...Read more
Good experience: Rituxan (rituximab) has been used in rheumatoid arthritis and it has demonsrated good response-in my experience. Jus like anything else, there are some possible side effects from Rituxan (rituximab) but majority are very tolerable. You need to be screened for hepatitis b - prior to Rituxan (rituximab) administration.-as Rituxan (rituximab) can cause hep b exacerbation. ...Read more
My daughter taking naproxin for joint pain/ possible jra. How long before we notice a difference!? If this don't work what are other meds ?
How common is it to use both methotrexate and hydroxychloroquine in treating juvenile arthritis? Is this safe? What should I know before starting?
JiA treatment: For multi-drug therapy for jia, Methotrexate is more commonly paired with biologic medication. For methotrexate, watch for mouth sores and nausea. Blood testing will be needed to check blood counts and liver tests. For treatment with plaquenil, (hydroxychloroquine) plan to have annual eye exams. ...Read moreSee 1 more doctor answer
Child on methotrexate 25mg rheumo just added plaquenil (hydroxychloroquine) for jra. How long will it take for plaquenil (hydroxychloroquine) to work? If this doesn't help what next step?
Taking indomethacin & colchicines for gout, 10 years. Doctor recommends allopurinol. Says once i start allopurinol, I have to stay on it for life & that i can’t stop taking it. Is this true?
Get proper treatment: Be sure to see a board certified pediatric rheumatologist.General pediatricians and family medicine docs are not familiar or comfortable with using weekly low dose Methotrexate and TNF inhibitors that are needed to control 99% of kids with correctly diagnosed JIA/JRA.It's worth traveling some distance to see a pediatric rheumatologist since most adult rheumatologists do not treat it as effectively ...Read moreSee 3 more doctor answers
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