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Doctor insights on: What Happens If You Don't Take Anti Rejection Drugs

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What if transplant patient forgets to take anti rejection drugs?

What if transplant patient forgets to take anti rejection drugs?

Rejection: The recipient's immune system will attack the transplanted organ and it will suffer an rejection. It may take weeks to months before the non-compliant patients start to have symptoms or signs of kidney failure. ...Read more

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Does a person who had a bone graft have to take anti rejection drugs?

Does a person who had a bone graft have to take anti rejection drugs?

NO: The grafting material, unless it is your own bone, usually only provide a scaffold for your blood vessel to proliferating and bring in your own bone cell, differentiate, and mature into your bone. Anti rejection drug applied more for using a live graft (an organ, bone marrow, etc.) and assuming its function. Thus anti rejection drug is not prescribed for bone graft procedure. ...Read more

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Can I take my two different anti rejection drugs at the same time?

Can I take my two different anti rejection drugs at the same time?

Depends: There are certain anti-rejection meds with significant drug-drug interaction that makes it necessary to take them separately. A good example is cyclosporine and sirolimus and one needs to take them separately (usually 4 hrs apart). I encourage you to speak to your transplant physicians/nurse coordinators for detailed information. ...Read more

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What might happen if a person does not take anti-rejection medicine three times consecutively?

What might happen if a person does not take anti-rejection medicine three times consecutively?

Rejection risk: Hi. Rejection depends on multiple variables, and therefore is fairly unpredictable. Why has the patients skipped 3 consecutive doses? I would recommend talking with the transplant physician to see what needs to be done. Rejection is not a good thing. This patient should be more compliant with the antirejection regimen. Good luck to the patient! ...Read more

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What if you forget to take your anti rejection meds on time, but do take them a couple hours later every day?

OK: That should be fine. No doc ever expects you take the meds exactly 24 hours apart. Take them as close to that as you can. A few hours here and there won't make any real difference. ...Read more

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How much time does it take to die after going off of kidney transplant anti- rejection meds?

How much time does it take to die after going off of kidney transplant anti- rejection meds?

Hard to say.: Immunosuppression medications are necessary to prevent the body from attacking the transplanted kidney. If the medications are stopped, the body begins to attack (reject) the organ and the kidney will eventually fail. Once this happens, dialysis will need to be started. Many factors affect the rate at which the body attacks the kidney, making an exact answer to your question difficult. ...Read more

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Is it safe to stop anti rejection drugs for organ transplant after 3 years since no complications developed?

Is it safe to stop anti rejection drugs for organ transplant after 3 years since no complications developed?

No: You should never change your immunosuppressive drug doses without first discussing this with your transplant team. A transplant recipient can reject their graft at any time after the transplant. ...Read more

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People have anti-rejection drugs for organ replacement why can't you have the same for blood transfusions?

People have anti-rejection drugs for organ replacement why can't you have the same for blood transfusions?

It's not necessary: Rejection of a blood transfusion is called a "transfusion reaction." blood banks can almost always find a donor blood product which won't cause a reaction so anti-rejection drugs are usually not required. ...Read more

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Anti rejection drugs from heart transplant, can this cause personality change?

Anti rejection drugs from heart transplant, can this cause personality change?

Not impossible: Talk with your physicians to let them know the details and perhaps they can make changes that will help. Absolutely do not change your dose or medication without doctor's advice. Promise? Be well! ...Read more

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What happens if you forget a dose of anti rejection meds?

What happens if you forget a dose of anti rejection meds?

Depends: If you miss just one dose of anti-rejection meds, the risk of that precipitating a rejection is likely low. However, it is the repeated non-compliance with meds that often leads to poor patient and graft outcome. I encourage patients to have extra meds with them if they are going out (in case they cannot get back in time). Your immune system has a very good long-term memory. ...Read more

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How safe are anti-rejection meds?

Safer than Rejection: All medicines have side effects. It's the job of the transplant clinic to find the right cocktail for each patient which will prevent rejection with minimal side-effects. Because most patients are on combination therapy, there is a great deal of art as well as science which goes into finding the best combination of drugs. ...Read more

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Why can't I eat grapefruit while on anti-rejection meds for 2 different transplants?

Why can't I eat grapefruit while on anti-rejection meds for 2 different transplants?

Affects your levels: If you drink grapefruit juice or eat grapefruits your Prograf levels will be higher. This may cause your surgeon to lower your dose then when you are not enjoying your grapefruit your levels will be low and your grafts will be at risk for rejection. ...Read more

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I just had an l3-s1 fusion. Do I need to be taking anti rejection medication?

No: After spinal fusion, I would recommend you avoid nsaids or steroids. These inhibit inflammation which actually helps the fusion process to complete. Otherwise, meds as prescribed by your surgeon and resumption of other medication prescribed by other doctors is fine (even blood thinners generally ok a week or so after fusion). Rejection meds are not typically used after spine fusion. ...Read more

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Can anti rejection tablets damage ya heart?

Can anti rejection tablets damage ya heart?

Needs clarification: I believe you are asking whether anti-rejection medications cause damage to the heart. Anti-rejections themselves do not cause coronary artery disease but organ transplant recipients are at increased for cardiovascular disease. Some anti-rejection meds can cause or contribute to worsening hypertension, high cholesterol, or diabetes and therefore increase the risk of heart disease and stroke. ...Read more

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What to do if I need help clearing acne caused by anti-rejection medication?

What to do if I need help clearing acne caused by anti-rejection medication?

Variety of choices: The Cyclosporine family famously cause people to break out with acne. Your physician knows some options -- have you tried topical clindamycin? ...Read more

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Do everyone who have organ transplant have to be on anti-rejection medicine forever?

Do everyone who have organ transplant have to be on anti-rejection medicine forever?

Yes: At the present time there is no "one time" or permanent antirejection formulation. ...Read more

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I have had a kidney transplant 14 years ago what are the chances of getting off some anti rejection pills?

I have had a kidney transplant 14 years ago what are the chances of getting off some anti rejection pills?

This is a discussion: You will need to have with your specialist as there are multiple variables which contribute to the necessity to remain on immunosuppressants. ...Read more

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What does a steroid resistance transplant mean? Are steroids first line for anti-rejection prophylaxis?

What does a steroid resistance transplant mean? Are steroids first line for anti-rejection prophylaxis?

Steroids: In the old days- which really is in the last 29 years steroids have always been first line therapy for transplants. Recently physicians have been moving to steroid- free protocols because of the side effects of steroids including diabetes, weight gain and bone disease. Steroid resistant if that is what you mean may be someone who is not a candidate for steroid therapy. ...Read more

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What to do if heart transplant anti rejection meds= kidney disease /failure?

What to do if heart transplant anti rejection meds= kidney disease /failure?

Be careful: Unfortunately, the medicines that keep the transplanted heart working have significant side effects, like renal failure. Your dosages and levels need to be monitored very carefully by your medical team. Good luck. ...Read more

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What do you advise for heart transplant anti rejection meds= kidney disease /failure?

What do you advise for heart transplant anti rejection meds= kidney disease /failure?

Transplant: Heart transplant management is a very specialized area and specific recommendations to a particular patient are necessary. The patient should be followed by the transplant team who knows the details of the specific patient. Making blanket recommendations in a place like this isn't a good idea ...Read more

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Help please? What is the best medication/drug for rejection?

Help please? What is the best medication/drug for rejection?

Depends: It depends on what organ is getting transplanted and how likely the recipient is going to have a rejection episode and what other medical conditions the patient has. For example, for a kidney transplant, most patients are going to be on 2 or 3 anti-rejection meds and they will likely include tacrolimus (Prograf) and mycophenolate (CellCept (mycophenolate mofetil) or Myfortic). ...Read more

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Can any doc tell me what's the best medication/drug for dealing with rejection?

Can any doc tell me what's the best medication/drug for dealing with rejection?

Talk to an expert: I suggest that you see your doctor or a psychologist to voice out how you really feels. There are numerous medications for depression but there are many factors that need to be considered to come up with the best medication for you, such as medical history, other meds taken, etc. ...Read more

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How long after a tissue donation do I have to take medications to prevent rejection?

How long after a tissue donation do I have to take medications to prevent rejection?

Generally: For tissue donation (as compared to organ donation) no medications are needed to prevent rejection as the tissues are irradiated thoroughly and go through a very strict process so no blood or blood products are present on them when they are transplanted. Therefore, there is no chance of "rejection". ...Read more

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Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?

Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?

Not aware of any: Monoclonal antibody therapy, which blocks immune responses of key white cells (T-cell lymphocytes) is relatively new, but I am unaware of novel techniques to remove antigens from donor organs. You may want to discuss this with a large medical center transplant program if you are interested in new therapies or even in participating in a research study. ...Read more

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I saw on CNN a lady who received an organ transplant but it was altered before transplanting to avoid rejection, no drugs needed. How's that possible?

I saw on CNN a lady who received an organ transplant but it was altered before transplanting to avoid rejection, no drugs needed. How's that possible?

Trsplt- No immunosup: Please see the references below. Some protocols are developing to wean people off immunosupression which was unheard of before, I ma not sure if this is what you are referring to:

http://www. Aafp. Org/afp/2008/0101/p65.html

http://www. Nejm. Org/doi/full/10.1056/NEJMoa071074

Proc Natl Acad Sci U S A. 2013 Nov 19;110 (47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28 ...Read more

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Serious inquiry into transplant surgery rejection drugs?

Transplant: Not sure what the question is. Best to talk to a surgeon for input. ...Read more