Doctor insights on:
What Happens If I Stop Taking My Immunosuppressive Drug Suddenly
What happens to the GFR of the transplanted kidney? Will it initially rise due to compensatory increase and then reduce due to immunosuppressive drugs
Great question but: Has several complex issues are involved , GFR is the litmus paper how good the kidney is functioning , assessed indirectly based on creatinine levels , yes the drugs especially steroids acts on muscle wasting , produce less of creatinine , there by showing higher GFR value , not due to compensation . It is also possible to get true GFR estimation by non creatinine based testing , usually not done. ...Read moreSee 1 more doctor answer
Basically: Immunosupressives try to minimize your body's rejection of a foreign substance (like a organ transplant). Your body's first response will be to recognize this "foreigner" and get your white blood cells and other immune system "good guys" to get rid of it. This is also what happens when you have an autoimmune disease like lupus (basically you develop an immunity to yourself). ...Read more
To decrease immunity: Immunosuppresive agents are drugs that decrease immune function. While in most situations this would be undesirable, with certain conditions where the immune system is overactive or too aggressive, these drugs may be proper. Examples include to prevent rejection of transplanted organs, in autoimmune conditions to prevent tissue destruction, and in diseases with chronic inflammation like asthma. ...Read moreSee 1 more doctor answer
Immune disorders: Immune suppressive drugs works just as they sound- to suppress the type of overactive immune responses causing the illnesses . The type of drug used would depend on the type of immune reactions specific to that disease. ...Read more
A lot: Organ rejection is a complex and not entirely understood immunologic process. Different immunosuppressive drugs are designed to interrupt different parts of this cascade of processes. Each drug has different efficacy and side-effect profiles. Most of the time clinicians employ a combination of multiple drugs and adjust their dosages to maximize efficacy & minimize side-effects. ...Read more
In General, Yes: However, identical twins (same placenta) don't since they do not reject organs and tissues. In addition, there may be a few recipients with a sluggish immune system that don't appear to reject their transplanted organ. We call this tolerance, and it is a very hot area of research. The doses of is drugs usually can be decreased over time, and some recipients actually take very little. ...Read moreSee 1 more doctor answer
Rejection: Your immune system sees any transplant as a foreign object. It treats the cells of the transplant just like bacteria cells it works to destroy them. This would cause the transplant to be destroyed or rejected. The immunosuppression runs down the volume of the immune system so it cannot kill off the transplant so easily. ...Read more
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