Doctor insights on:
What Happens If I Stop Taking My Immunosuppressive Drug Suddenly
Comes back: Rarely does RA go into true remission without getting worse after stopping the immunosuppressives. This is particuarly true for methotrexate. Many people have stopped gold therapy without a return of the arthritis for many years. Occasionally biologics can be stopped after several years of remission but the RA usually returns. ...Read moreGet help from a doctor now ›
What happens to the GFR of the transplanted kidney? Will it initially rise due to compensatory increase and then reduce due to immunosuppressive drugs
Great question but: Has several complex issues are involved , GFR is the litmus paper how good the kidney is functioning , assessed indirectly based on creatinine levels , yes the drugs especially steroids acts on muscle wasting , produce less of creatinine , there by showing higher GFR value , not due to compensation . It is also possible to get true GFR estimation by non creatinine based testing , usually not done. ...Read moreGet help from a doctor now ›
Basically: Immunosupressives try to minimize your body's rejection of a foreign substance (like a organ transplant). Your body's first response will be to recognize this "foreigner" and get your white blood cells and other immune system "good guys" to get rid of it. This is also what happens when you have an autoimmune disease like lupus (basically you develop an immunity to yourself). ...Read moreGet help from a doctor now ›
To decrease immunity: Immunosuppresive agents are drugs that decrease immune function. While in most situations this would be undesirable, with certain conditions where the immune system is overactive or too aggressive, these drugs may be proper. Examples include to prevent rejection of transplanted organs, in autoimmune conditions to prevent tissue destruction, and in diseases with chronic inflammation like asthma. ...Read moreGet help from a doctor now ›
A lot: Organ rejection is a complex and not entirely understood immunologic process. Different immunosuppressive drugs are designed to interrupt different parts of this cascade of processes. Each drug has different efficacy and side-effect profiles. Most of the time clinicians employ a combination of multiple drugs and adjust their dosages to maximize efficacy & minimize side-effects. ...Read moreGet help from a doctor now ›
In General, Yes: However, identical twins (same placenta) don't since they do not reject organs and tissues. In addition, there may be a few recipients with a sluggish immune system that don't appear to reject their transplanted organ. We call this tolerance, and it is a very hot area of research. The doses of is drugs usually can be decreased over time, and some recipients actually take very little. ...Read moreGet help from a doctor now ›
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