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Doctor insights on: What Goes Wrong With Your Genes When You Have Scid

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What goes wrong with your genes when you have scid?

What goes wrong with your genes when you have scid?

SCID: Nothing is technically wrong with your genes, it is simply that there are chromosomal abnormalities that are essential for the development of the immune system. When they are not present, the failure of the normal immune system to develop leads to scid. ...Read more

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Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more


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Are there any causes besides genetics of developing scid?

Are there any causes besides genetics of developing scid?

SCID: None that have been discovered unless the newborn had a serious or severe cancer/leukemia requiring chemotherapy and radiation which wipes out the immune system. Additionally, certain diseases (itp, etc.) that require strong therapy (rituxan) can wipe out the immune system. ...Read more

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Explain how gene theraphy would be used to treat scid?

Explain how gene theraphy would be used to treat scid?

Not all: Some forms of scid involve gene mutations which are known and sequenced. In these forms it is possible to insert the proper gene and fix the mutation. ...Read more

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Is there a genetic test during pregnancy for scid?

Is there a genetic test during pregnancy for scid?

See below: There is no scid test for the fetus during pregnancy. Newborn screening for scid is available but varies from state to state. ...Read more

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Is there a way to treat severe combined immunodeficiency with gene therapy?

Is there a way to treat severe combined immunodeficiency with gene therapy?

Maybe: In the future gene therapy may be the way we treat scid, but right now the details of how to do this safely have not been proven. At the present time, bone marrow transplant is the mainstream of treatment. Trials may once again start with gene therapy at a few centers in the near future to see if this can be done safely. ...Read more

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Is scid communicable?

No: Severe combined immunodeficiency (scid) is a genetic abnormality with the immune system. It is, therefore, not infectious (or communicable) to others. Scid patients, however, are highly susceptible to any infectious disease including those that would not usually cause disease in people with normal immune systems. ...Read more

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Is scid a problem with the chromosomes?

Is scid a problem with the chromosomes?

Yes: There are several different problems with chromosomes that lead to severe combined immunodeficiency disease (scid). ...Read more

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What chromosome is scid associated with?

What chromosome is scid associated with?

X-linked SCIDs assoc: Mutations in 9 different genes have been found to cause the human scids. The products of 3 of the genes: 2rg, jak3, and il-7r? -are components of cytokine receptors, and 3 more: rag1, rag2, & artemis -are essential for effecting antigen receptor gene rearrangement. A deficiency of cd3?, a component of the t-cell antigen results in a near absence of circulating mature cd3+ & complete lack of ?/? tc. ...Read more

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What kind of mutation occurs in scid disease?

Depends: There are too many different types of scid - severe combined immunodeficiency for there to be just one mutation. Scid is commonly referred to as "bubble boy" disease in the lay press. The most common type is linked to the x chromosome and causes a defect in t cells and natural killer cells. ...Read more

Dr. David Rosenthal
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Severe Combined Immunodeficiency (Definition)

Severe combined immunodeficiency is a group of inherited conditions that result in severe abnormalities of the immune system. It usually causes one or more serious infections in newborns that ...Read more