Doctor insights on:
What Goes Wrong With Your Genes When You Have Scid
SCID: None that have been discovered unless the newborn had a serious or severe cancer/leukemia requiring chemotherapy and radiation which wipes out the immune system. Additionally, certain diseases (itp, etc.) that require strong therapy (rituxan) can wipe out the immune system. ...Read moreSee 1 more doctor answer
Not all: Some forms of scid involve gene mutations which are known and sequenced. In these forms it is possible to insert the proper gene and fix the mutation. ...Read more
Maybe: In the future gene therapy may be the way we treat scid, but right now the details of how to do this safely have not been proven. At the present time, bone marrow transplant is the mainstream of treatment. Trials may once again start with gene therapy at a few centers in the near future to see if this can be done safely. ...Read moreSee 1 more doctor answer
No: Severe combined immunodeficiency (scid) is a genetic abnormality with the immune system. It is, therefore, not infectious (or communicable) to others. Scid patients, however, are highly susceptible to any infectious disease including those that would not usually cause disease in people with normal immune systems. ...Read moreSee 1 more doctor answer
X-linked SCIDs assoc: Mutations in 9 different genes have been found to cause the human scids. The products of 3 of the genes: 2rg, jak3, and il-7r? -are components of cytokine receptors, and 3 more: rag1, rag2, & artemis -are essential for effecting antigen receptor gene rearrangement. A deficiency of cd3?, a component of the t-cell antigen results in a near absence of circulating mature cd3+ & complete lack of ?/? tc. ...Read more
Depends: There are too many different types of scid - severe combined immunodeficiency for there to be just one mutation. Scid is commonly referred to as "bubble boy" disease in the lay press. The most common type is linked to the x chromosome and causes a defect in t cells and natural killer cells. ...Read more
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