Doctor insights on:
What Exactly Is Tamoxifen Therapy
Anti-estrogen: Tamoxifen is a molecule that can attach to estrogen receptors ( sticky hands on cells that like estrogen). If estrogen (female hormone) binds these receptors it typically causes growth/ turn cell on. Tamoxifen mimics estrogen but can have the opposite effect, hence anti-esteogen. Tamoxifen by attachment can turn cells off (in some breast cells) or turn cell on( in uterus). ...Read moreSee 1 more doctor answer
This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more
There was some mention this year of increasing tamoxifen therapy to 10 years instead of 5 (post ca rx). What is the current thought on this?
Good question: The atlas trial presented about a year ago showed that 10 years of post-op tamoxifen led to decreased recurrence and mortality as compared to 5. An older trial done in the us did not show that, but the atlas is a more robust trial with over 12, 000 women. Many of us are now keeping patients on tam for 10 years or adding 5 years of Letrozole after 5 of tam as in the ma.17 trial. The question is... ...Read more
Is combined tamoxifen plus hormonal therapy more effective in pre or postmenopausal women and why?
Tamoxifen: We don't give tamoxifen in combination with hormone replacement in the us. Occassionally use vaginal very low dose estrogen cream for vag dryness and tell pts to use a little as they can to relieve symptoms. Blocking hormones and giving them at same time does not make much sense. ...Read more
I complete tamoxifen therapy (chemoprevention for adh) on 1 jan. Should i wait til then to start methotrexate (recently diagnosed with ra)?
Don't have to wait: There is no significant interaction between tamoxifen and methotrexate, so you can start any time. Methotrexate is a disease-modifying agent and takes couple of months to work, thus starting earlier is better, for most cases. It is only a month and a half before completing tamoxifen, so it is not that long of a wait if you so choose. I would advise informing your doc of your concern. Good luck. ...Read moreSee 1 more doctor answer
Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?
Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read moreSee 2 more doctor answers
What are the risks of breast cancer returning within a year of original treatment if taking tamoxifen?
Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone. Last year i had early catch stage-1 breast cancer. I next had a lumpectomy and only one treatment of chemotherapy. I was scheduled for four treatments. The side affects
If : If your breast cancer was estrogen receptor-negative then you will not benefit from hormonal adjuvant therapy like tamoxifen (actually women who are past their menopause should be on Arimidex not tamoxifen) either way you will not benefit from those since your mass is estrogen receptor negative. At 67 you should probably still get radiation as you still have a long life ahead of you...Especially with stage 1 cancer. You have to discuss these options with a breast surgeon... ...Read moreSee 2 more doctor answers
Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read moreSee 1 more doctor answer
Dear dr, i just wanna ask what is the best way treat gynocamastia condition .? And is the tamoxifen 40mg is a good treatment ? Is surgery needed ?
Yes: Tamoxifen is the medical treatment of choice for gynecomastia. If gynecomastia has been there less than 6 mths then medicine can often cause it to shrink. However, if it has been there longer then it often will develop fibrosis or scar tissue and can only be removed at that point with surgery. So surgery is usually recommended when of longer duration or medicine does not work. ...Read more
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