Doctor insights on:
What Exactly Is Hypergammaglobulinemia
Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more
Subtle disease: It's caused by inactivation, by autoantibody or exacerbation of a birth defect, of the protein that clear activated von willebrand's factor. Little blood clots interfere with kidney and brain function, there is a fever, and unless the plasma is replaced repeatedly (the mainstay of treatment), it is fatal. Thrombotic thrombocytopenic purpura. ...Read more
Gene for bleeding: The two common hemophilias are lack of factor viii (hemophilia a) and factor ix (hemophilia b) respectively. Of variable severity, these people are prone to bleed too easily especially from blunt trauma. Treatment consists of replacement of the missing factor and is a complicated business with specialists that are well-equipped to do this. Cure by gene therapy may soon be here for ix. Good luck. ...Read more
Autoimmune: Systemic lupus erythematosus is an auto immune illness. This means people have a immume response against themselves and their own tissues. The hallmark blood test is a positive anti-nuclear antibody or an ana. Depending on what tissue is involved results in the clinical symptoms such as rash, arthritis, kidney disease etc. ...Read more
Excess thyroid hormo: Hyperthyroidism occurs when your body is exposed to too much thyroid hormone (secreted by the thyroid gland, which sits at the base of the neck). Thyroid hormone controls metabolism so hyperthyroidism typically causes increased metabolism. Some of the symptoms include: increased appetite but weight loss, increased heart rate, tremor, diarrhea, feeling hot all the time, and anxiety. ...Read moreSee 1 more doctor answer
Bile Duct Infection: Ascending cholangitis describes an infection in the bile duct, usually secondary to obstruction. Common causes include bile duct stones, strictures, or tumors. These infections can be very serious because bacteria readily enter the bloodstream from the liver. Rx includes antibiotics +/-relief of the obstruction via endoscopy (ercp). ***sclerosing cholangitis is an unrelated inflammatory dz***. ...Read more
Immoglobulin finding: If a person has an unusually large number of antibodies, but not a single one in great excess, we speak of a polyclonal gammopathy; it's never a specific finding. An abundance of a single antibody is a monoclonal antibody "spike" that is quite common but may indicate or precede (often by decades) plasma cell "multiple" myeloma. ...Read more
Elevated potassium: Hyperkalemia in an elevated potassium level in the blood. It can be severe to mild. Most common causes are kidney disease and Addison's disease (adrenal disease0. It can occur in crush injuries and rhabdomyolysis (rapid breakdown of muscle). Severe hyperkalemia can be fatal and cause the heart to stop beating. It is usually treated by dialysis and fluids, with Insulin and sodium bicarbonate. ...Read more
Gene mutation: When someone inherits a defective gene from two unaffected parents they can have pku. They can't make the enzyme phenyalanine (phe) hydroxylase.The dietary protein phe cannot be broken down & the phe level raises in the blood & urine. Untreated it will cause brain damage, short stature & seizures. Treatment includes avoiding phe containing foods, meds & regular followup. ...Read moreSee 1 more doctor answer
Rheumatic Disease : The study of rheumatic diseases which include arthritis, bursitis, tendonitis, soft tissue diseases, immunologic diseases, osteoporosis, back pain, rheumatoid arthritis, systemic lupus erythematosus, connective tissue diseases to name a few. There are over 100-150 rheumatic diseases. ...Read moreSee 2 more doctor answers
Brain tumor: Astrocytoma describes a brain tumor that arises from the cell called the astrocyte in the brain. These are supportive cells that are diffusely located in the normal brain. These tumors can be slow growing or very fast growing and aggressive. The most common type of brain tumor in adults is a type of astrocytoma called a glioblastoma multiforme. These tumors don't go all over the body. ...Read more
Anemia...: Anemia (low hemoglobin) is caused by the body losing blood (heavy periods, blood in stool, red blood cell instability [hemoglobinopathies] or destruction [hemolysis]), the bodies inability to produce new red blood cells (for example iron deficiency), or a combination of these. Many causes of anemia are treatable, and some are inherited (sickle cell). A hematologist can help. ...Read moreSee 1 more doctor answer
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