Doctor insights on:
What Does Spironolactone Do To Help Heart Failure
Not just a diuretic: The medication is a diuretic, and helps to remove fluid in those that are congested due to heart failure. However, it not only improves symptoms, but actually reduces risk of dying in CHF patients, probably due to inhibiting the renin-angiotensin system, which is dysregulated in heart failure patients and felt to have adverse consequences on the heart and vasculature. ...Read moreSee 1 more doctor answer
Heart failure is a complex set of conditions in which the heart "fails" to pump a normal amount of blood with each beat. This can be due to poor squeezing function (systolic heart failure) and/or a stiff heart incapable of filling normally (diastolic heart failure). Common symptoms include swelling and trouble breathing, particularly when ...Read more
I am rx'd 25mg of spironolactone for heart failure and bottle states take half, i wasn't paying attn and took it whole. Will i be ok?
Should be: Just be sure to take the correct dose from now on. ...Read more
Improved survival: Spironolactone lowers blood pressure and initiates diuresis while sparing magnesium & potassium. It's an older drug that has found new use now because it blocks aldersterone from injuring heart muscle & increases heart muscle norepinephrine. Studies show it improves survival in left heart failure. See http://www.Ncbi.Nlm.Nih.Gov/pubmed/10995520. ...Read moreSee 1 more doctor answer
Indirectly: Leukemias are liquid cancers. Some chemotherapy agents kill leukemia cells but also permanently damage and or kill cardiac cells.Some patients get cured of their leukemias to succumb later to complications of heart failure. Some, specially children may be a candidate to heart transplant if the leukemia has been cured over 5 years. Still, inmmunosuppresion can lead to lethal infections or cancer. ...Read more
Possibly: During the phenertermine scare several years ago, certain valvular disorders as well as pulmonary artery hypertension were associated with its use in weight loss regimens. Heart failure was a possible result. Some older diet pills are variants of amphetamines, which is a "sympathomimetic". Chronic use of such agents can lead to cardiomyopathy that may result in heart failure. New agents better? ...Read more
Hormonal: Severe and chronic heart failure can set into motion alterations of chemicals in the blood similar to other severe illnesses. Additional changes in appetite and psychological changes can affect diet as well as physical deconditioning. All of these factors can cumulatively lead to muscle wasting syndromes. Mild heart failure is usually not associated with these severe physiologic manifestations. ...Read more
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