Doctor insights on:
What Does It Mean When Your Glutamate Decarboxylase Antibody Test Is Positive
Insulin in future?: Glutamic acid decarboxylase antibodies (gada) is the most important factor for prediction of Insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Is is one of several pancreatic antibodies, but the best predictor of type one disease. ...Read more
What things, in the body, regulate glutamic acid? Glutamic acid decarboxylase? Glutamate receptors (nmda, ampa...Etc.)? What else is involved?
It's complicated...: There are some very exciting discoveries on the metabolism of glutamate... There are multiple pathways impacting on things such as gaba neurotransmitter, nitrogen clearance from the liver portal, etc... These pathways play vital roles in survival! please read this.... And email me your questions if you'd like! http://voh.Chem.Ucla.Edu/vohtar/spring04/classes/153ch/pdf/kelly%20and%20stanley.Pdf. ...Read more
I have a glutamic acid decarboxylase antibody level of 3.4 u/ml. Is this anything to worry about? Labcorp says the result is "high".
Why ordered?: This is supposed to be a marker for a kid who's likely to get juvenile onset diabetes. Are you perhaps a newly-diagnosed diabetic? There's talk that elevated antibodies sort-of predicts that diabetes in an adult will behave more like type i diabetes (require insulin) than type ii, but i'm not aware of a consensus on whether there is a treatment guideline. Read up & ask for a clear answer. ...Read more
My daughter (7 yrs) blood test of antiglutamic acid decarboxylase (gad) is 54.000 iu/ml, what does it mean? Is there a way to stop its function?
Biochemistry: Gad is an enzyme that your body needs to make the neurotransmitter gaba. If this was drown in a child, i suspect that they are considering a spinocerebellar ataxia syndrome (sca) or hyperekplexia. These are complicated and rare disorders. Your child may need to a see a child neurologist with some expertise in neuromuscular disorders if anything unusual is being considered. ...Read more
L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse. Could I have glutamate metabolism disorder or glutamate receptor antibodies?
Possibly but...: Good question without an easy answer. Glutamate is an "excitotoxin" that is not healthy for anyone but some people are more sensitive to it than others. There are a variety of uncommon glutamate metabolism disorders but you do not need to have one of these to be adversely affected by glutamate. Dysesthesias are not a known symptom of antibodies to glutamate receptors. See my comments:. ...Read more
In my recent blood test my glucose was 204. C-peptide was 0.37 and glutamic acid decarboxylase was >30.0.
Also my hemoglobin A1c was 10.1?
Type I diabetes.: With a hemoglobin A1C so high and I assume a high fasting glucose, unfortunately, it appears that you are diabetic. A high glutamic decarboxylase can mean anti-islet cell of the pancreas antibodies, but can also be elevated in other autoimmune conditions. A lower C-peptide and positive antibodies indicate Type I diabetes. If you are not on insulin yet, please seek help ASAP in the ER. ...Read more
Depends: Why was the test ordered? I would contact the Dr who ordered the test to explain the results to you. They know the clinical context. Low Positive can also mean not exactly positive or not clinically significant. ...Read more
I had a antibody nuclear titer test and the results are 1:320 what're does this mean? I also had a antibody nuclear interpet which tested positive
Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, if this is the only abnormality, it is not to be concerned about. Please consult this site for information and discuss the matter with your doctor. http://www.lupus.org/answers/entry/lupus-diagnostic-criteria ...Read more
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