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Doctor insights on: What Does It Mean By Positive To Anti Double Stranded Dna

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Dr. Albert Pizzo
Board Certified, Family Medicine
55 years in practice
47M people helped
1

1
Hello. I have a positive double stranded DNA test result (anti-dna (ds) ab qn of 29 with positive being above 9. Ana is negative, what can this mean?

Dr. Albert Pizzo
Board Certified, Family Medicine
55 years in practice
47M people helped
Hello. I have a positive double stranded DNA test result (anti-dna (ds) ab qn of 29 with positive being above 9. Ana is negative, what can this mean?

Abnormal tests: Best to discuss this question with the doctor ordering your tests. ...Read more

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Dr. Jonathan Jassey
Board Certified
12 years in practice
825K people helped
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Dr. Jonathan Jassey
Board Certified
12 years in practice
825K people helped
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Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped
2

2
What does it mean if your double stranded DNA test comes back positive?

Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped

hard to say: The results need to be evaluated in the context of the clinical picture. What symptoms led to the test being ordered in the first place? ...Read more

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Dr. Jonathan Jassey
Board Certified
12 years in practice
825K people helped
Get help from a real doctor now
Dr. Jonathan Jassey
Board Certified
12 years in practice
825K people helped
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Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped
3

3
My anti double stranded DNA test came back at 6. Is this positive?

Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped

No: That result is negative.

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Dr. Bruce Rothschild
Board Certified, Rheumatology
36 years in practice
2M people helped
4

4
Positive ana, anti double stranded DNA of 6 and sjogrens ant ss b of 2.7? Normal?

Dr. Bruce Rothschild
Board Certified, Rheumatology
36 years in practice
2M people helped

Depends: Depends on normal range for those tests and positive ANA is meaningless without knowing the titer. ...Read more

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Dr. Jonathan Jassey
Board Certified
12 years in practice
825K people helped
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Dr. Venkata Chilakapati
Board Certified, Cardiology
18 years in practice
1M people helped
5

5
My double stranded DNA is 6 which is "indeterminate" what does "indeterminate" mean when it comes to this test?

Dr. Venkata Chilakapati
Board Certified, Cardiology
18 years in practice
1M people helped
My double stranded DNA is 6 which is "indeterminate" what does "indeterminate" mean when it comes to this test?

DNA: There is no such thing dna 6. Are you taking about human herpes virus 6 dna detection test. If so, indeterminate means antibody titer is neither positive nor negative. It is falling in the grey zone. ...Read more

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Dr. Neal Birnbaum
Board Certified, Rheumatology
46 years in practice
143K people helped
6

6
Just diagnosed with lupus due to double stranded dna. My ch50 was 350 though. Usually this is low in lupus. What could this mean?

Dr. Neal Birnbaum
Board Certified, Rheumatology
46 years in practice
143K people helped
Just diagnosed with lupus due to double stranded dna.  My ch50 was 350 though.  Usually this is low in lupus.  What could this mean?

See rheumatologist: Serologic lab results in patients suspected as having lupus can be tricky to interpret. If you have not done so already, see a rheumatologist for a full evaluation. He/she can review your entire picture including the history and physical and can discuss the significance of the various lab tests. ...Read more

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Dr. David Sneid
Board Certified, Endocrinology
36 years in practice
38M people helped
7

7
How common is it to get a false positive for lupus while pregnant. I also have hashimotos got a + double stranded DNA very high ?

Dr. David Sneid
Board Certified, Endocrinology
36 years in practice
38M people helped
How common is it to get a false positive for lupus while pregnant. I also have hashimotos got a + double stranded DNA very high ?

It certainly: Can occur and is also associated weakly with your prior diagnosis of hashimoto's check w/ your doctor for more info. ...Read more

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Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped
8

8
I had a negative ANA test but positive double stranded DNA test do I have lupus?

Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped

Not enough data: The diagnosis of luppus is made on the basis of clinical signs and symptoms confirmed by specific lab tests including the dna antibody. This antibody can also be positive in other auto immune diseases. Since you did not mention symptoms, there is no way to answer your question. ...Read more

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Dr. Tracy Lovell
Board Certified, Rheumatology
16 years in practice
6M people helped
9

9
Would bloods for autoimmune screen ANA double stranded DNA ENA anca still show positive if there had been an autoimmune response even 6 years ago?

Dr. Tracy Lovell
Board Certified, Rheumatology
16 years in practice
6M people helped
Would bloods for autoimmune screen ANA double stranded DNA ENA anca still show positive if there had been an autoimmune response even 6 years ago?

See below: You also have to take in account that these panels frequently have false positives and assays vary from lab to lab. It is has been estimated that up 30% of all anas drawn are false positives. Only your doctor or your rheumatologist can interpret these results in context with your history and symptoms. ...Read more

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Randy Burgett
Board Certified, General Practice
4 years in practice
72K people helped
10

10
I had a positive ana, double stranded dna, and I believe smith's antibodies. I also had a butterfly rash at the time. Besides lupus, what could it be?

Randy Burgett
Board Certified, General Practice
4 years in practice
72K people helped

Probably Lupus: A butterfly rash is often seen with lupus, but could also been seen with vitamin deficiency disorders like pellagra or connective tissue disases like dermatomyositis. However, the positive ANA and smith's antibodies most likely indicate it is lupus. You should see your physician to be properly diagnosed. ...Read more

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Dr. Jonathan Jassey
Board Certified,
12 years in practice
825K people helped
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