Doctor insights on:
What Does Immunoglobulin M Low Mean
I have a very low igg3 and igg4, along with a very low immunoglobulin m and a high serum amyloid a - what does this mean?
See immunlogist: The low igg3 and igg4 in and of themselves may not mean much if your igg1 is normal. The fact that you also have low igm suggests that there may be an immune disorder. The high serum amyloid a likely signifies inflammation in your case. www.ncbi.nlm.nih.gov/.../10608507?. ...Read more
Depends: If IgM is elevated but IgA & igg are decreased then you have a significant immunodeficiency called hyper IgM syndrome. Other causes of elevated IgM include monoclonal gammopathy and multiple myeloma. Never ignore the possibility of a lab error - the next test to do is to repeat the IgM level. ...Read more
Waldenstrom's Dz: An elevation of immunoglobulin m (igm) in the serum esp. If monoclonal (of one kind) raises the possibility of waldenstrom's macroglobulinemia - a malignancy affecting lymphocytes or plasma cells that produce this abnormal IgM protein causing symptoms of hyperviscosity - confusion, shortness of breath, stroke, kidney damage etc. ...Read more
High IgM: This is typically normal if seen on any one spot check. If it is high repeatedly on two or more checks, a test called " immunofixation" should be ordered to be sure it is not coming from only one population of blood cells; rarely, this could be due to a monoclonal gammopathy (a pre-cancerous condition). Or even rarer, a blood cell cancer called multiple myeloma. ...Read more
Depends: Igm & ige are the first antibodies to rise in the face of infection. As the body refines its immune response IgA & igg antibodies specific for the infecting agent are produced while specific IgM levels fall. Rarely does the IgM response to an infection raise the total amount of igm. Exceptions are congenital infections. High total IgM in adults suggest autoimmune disease or malignancy. ...Read more
Is it normal to have borderline low immunoglobulin m (igm) levels? Do they fluctuate that much?...Or nothing to worry about? Doc wasn't worried.
Don't worry: It may fluctuate but i won't be concerned with an isolated low igm, let alone a borderline low one. The immunoglobulin levels , like any other products produced by the body, do fluctuate a little with time but usually within a narrow range in a healthy person. Some levels may elevate in the presence of infections or allergen exposure. ...Read more
What does it mean when your RDW and Immunoglobulin M are High and your AnaChoice Screen is Positive?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings suggest auto-immune red cell loss. It would be prudent to see your doctor who ordered these tests. ...Read more
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