Doctor insights on:
What Does Immunoglobulin M Low Mean
Unrelated: They are unrelated. Low IgM is usually not clinically significant (depending on how low of course). Talk to an allergist immunologist to figure this out. A high A1c would suggest diabetes. Talk to your primary care doctor.
Depends: If IgM is elevated but IgA & igg are decreased then you have a significant immunodeficiency called hyper IgM syndrome. Other causes of elevated IgM include monoclonal gammopathy and multiple myeloma. Never ignore the possibility of a lab error - the next test to do is to repeat the IgM level.
Waldenstrom's Dz: An elevation of immunoglobulin m (igm) in the serum esp. If monoclonal (of one kind) raises the possibility of waldenstrom's macroglobulinemia - a malignancy affecting lymphocytes or plasma cells that produce this abnormal IgM protein causing symptoms of hyperviscosity - confusion, shortness of breath, stroke, kidney damage etc.
High IgM: This is typically normal if seen on any one spot check. If it is high repeatedly on two or more checks, a test called " immunofixation" should be ordered to be sure it is not coming from only one population of blood cells; rarely, this could be due to a monoclonal gammopathy (a pre-cancerous condition). Or even rarer, a blood cell cancer called multiple myeloma.
None: There is no specific replacement therapy for low igm. This value, the low igm, needs to be interpreted in light of the rest of one's immunoglobulins.See 1 more doctor answer
Depends: Igm & ige are the first antibodies to rise in the face of infection. As the body refines its immune response IgA & igg antibodies specific for the infecting agent are produced while specific IgM levels fall. Rarely does the IgM response to an infection raise the total amount of igm. Exceptions are congenital infections. High total IgM in adults suggest autoimmune disease or malignancy.
What does it mean when your RDW and Immunoglobulin M are High and your AnaChoice Screen is Positive?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings suggest auto-immune red cell loss. It would be prudent to see your doctor who ordered these tests.
Is it normal to have borderline low immunoglobulin m (igm) levels? Do they fluctuate that much? ...Or nothing to worry about? Doc wasn't worried.
Don't worry: It may fluctuate but I won't be concerned with an isolated low igm, let alone a borderline low one. The immunoglobulin levels, like any other products produced by the body, do fluctuate a little with time but usually within a narrow range in a healthy person. Some levels may elevate in the presence of infections or allergen exposure.
Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?
Monoclonal processes: Are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory.See 1 more doctor answer
I have the following and no definitive diagnosis. Low (8.3)hgb, hct (25), require IV iron every 4-6 mo. Lately immunoglobulin m, qn serum 415.FATIGUE?
SEVERE ANEMIA: Can cause the fatigue you are having. Hope you are under the care of a hematologist or other specialist to get the right DX.
Acute event...: Acute immunologic event.......Get a more detailed answer ›
Can vaccinations administered before immunoglobulin test affect outcome specifically for immunoglobulin m levels?
Live viruses maybe: Live virus vaccines may affect the igm levels. It takes 10-14 days for vaccines to stimulate an antibody response. If labs are drawn within a few days the levels should not be that affected. Best advice is to wait for 3-4 weeks after a vaccine to have immunoglobulin test drawn. If not then let your doc know when the labs were drawn. Really not a big worry.
What can cause the Sedimentation Rate-Westergren - 70; Complement C4, Serum - 53; Immunoglobulin M, Qn, Serum - 36; Complement, Total (Ch50) >63?
Have lupus. Being tested for possible autoimmune liver diseases. Recent blood work showed immunoglobulin M elevated at 470 (range 26-217).?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, a single test like slightly elevated IgM is not meaningful. Lupus is a complicated illness and the individual needs to be treated, not a lab test result. Wish you good health.
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