Doctor insights on:
What Does Immunoglobulin M Low Mean
I have a very low igg3 and igg4, along with a very low immunoglobulin m and a high serum amyloid a - what does this mean?
See immunlogist: The low igg3 and igg4 in and of themselves may not mean much if your igg1 is normal. The fact that you also have low igm suggests that there may be an immune disorder. The high serum amyloid a likely signifies inflammation in your case. Www. Ncbi. Nlm. Nih. Gov/.../10608507. ...Read more
Depends: If IgM is elevated but IgA & igg are decreased then you have a significant immunodeficiency called hyper IgM syndrome. Other causes of elevated IgM include monoclonal gammopathy and multiple myeloma. Never ignore the possibility of a lab error - the next test to do is to repeat the IgM level. ...Read more
Waldenstrom's Dz: An elevation of immunoglobulin m (igm) in the serum esp. If monoclonal (of one kind) raises the possibility of waldenstrom's macroglobulinemia - a malignancy affecting lymphocytes or plasma cells that produce this abnormal IgM protein causing symptoms of hyperviscosity - confusion, shortness of breath, stroke, kidney damage etc. ...Read more
High IgM: This is typically normal if seen on any one spot check. If it is high repeatedly on two or more checks, a test called " immunofixation" should be ordered to be sure it is not coming from only one population of blood cells; rarely, this could be due to a monoclonal gammopathy (a pre-cancerous condition). Or even rarer, a blood cell cancer called multiple myeloma. ...Read more
None: There is no specific replacement therapy for low igm. This value, the low igm, needs to be interpreted in light of the rest of one's immunoglobulins. ...Read more
Depends: Igm & ige are the first antibodies to rise in the face of infection. As the body refines its immune response IgA & igg antibodies specific for the infecting agent are produced while specific IgM levels fall. Rarely does the IgM response to an infection raise the total amount of igm. Exceptions are congenital infections. High total IgM in adults suggest autoimmune disease or malignancy. ...Read more
What does it mean when your RDW and Immunoglobulin M are High and your AnaChoice Screen is Positive?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings suggest auto-immune red cell loss. It would be prudent to see your doctor who ordered these tests. ...Read more
Is it normal to have borderline low immunoglobulin m (igm) levels? Do they fluctuate that much? ...Or nothing to worry about? Doc wasn't worried.
It may fluctuate but I won't be concerned with an isolated low igm, let alone a borderline low one.
The immunoglobulin levels, like any other products produced by the body, do fluctuate a little with time but usually within a narrow range in a healthy person. Some levels may elevate in the presence of infections or allergen exposure. ...Read more
Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?
Monoclonal processes: Are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory. ...Read more
I have the following and no definitive diagnosis. Low (8.3)hgb, hct (25), require IV iron every 4-6 mo. Lately immunoglobulin m, qn serum 415.FATIGUE?
SEVERE ANEMIA: Can cause the fatigue you are having. Hope you are under the care of a hematologist or other specialist to get the right DX. ...Read more
Acute event...: Acute immunologic event.......Get a more detailed answer ›
Can vaccinations administered before immunoglobulin test affect outcome specifically for immunoglobulin m levels?
Live viruses maybe: Live virus vaccines may affect the igm levels. It takes 10-14 days for vaccines to stimulate an antibody response. If labs are drawn within a few days the levels should not be that affected. Best advice is to wait for 3-4 weeks after a vaccine to have immunoglobulin test drawn. If not then let your doc know when the labs were drawn. Really not a big worry. ...Read more
What can cause the Sedimentation Rate-Westergren - 70; Complement C4, Serum - 53; Immunoglobulin M, Qn, Serum - 36; Complement, Total (Ch50) >63?
Have lupus. Being tested for possible autoimmune liver diseases. Recent blood work showed immunoglobulin M elevated at 470 (range 26-217).?
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, a single test like slightly elevated IgM is not meaningful. Lupus is a complicated illness and the individual needs to be treated, not a lab test result.
Wish you good health. ...Read more
What could cause elevated immunoglobulin M (IgM)? IgM result is 468 mg/dl, all other bloodwork normal. Also shortness of breath, shoulder, rib pain
Infection, myeloma: IgM is the 1st antibody released by the immune system in the course of fighting an infection. Depending on the amount of other antibodies (even if normal), it could also represent a tumor or malignancy of the immune system, like lymphoma or myeloma. We can't diagnose that here. Use HealthTap Prime to upload the entire report (all tests) or talk to the doctor who ordered the bloodwork. Good luck. ...Read more
What would cause free kappa &free lamba to be high but ratio normal also Immunoglobulin M, Qn, Serum high. Platelets steady rising & WBC high for 1yr?
Polyclonal gammopath: Something is stimulating all the B cell lines to produce a lot of antibodies. That general condition is called polyclonal gammopathy. It can be caused by a chronic infection (virus) or 9 other broad categories of causes (liver problems, connective tissue diseases, bone marrow disorder like Waldenstrom's, drugs/meds, autoimmune probs, misc). It's too much to go into here. Use Healthtap Prime to tal ...Read more
Why would liver enzymes fluctuate in and out of range in 3 months? Ultrasound clear but immunoglobulin m was slightly elevated with ast 60 and alt 100
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it could be due to alcohol use, some medication you are taking or being overweight. Or you may have chronic liver inflammation. You should talk to the doctor who ordered the tests. ...Read more
Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?
PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces immunoglobulin (antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see hematologist (blood doctor specialist). ...Read more
If u have Vitamin D deficiency, does this have any effect on immunoglobulin levels (IgG, IgM...etc.)? Would low Vitamin D cause lower IgG or IgM?
Bovine Colostrum: Bovine colostrum from pasture-fed cows contains immunoglobulins specific to many human pathogens, including escherichia coli, cryptosporidium parvum, shigella flexneri, salmonella, staphylococcus,  and rotavirus (which causes diarrhea in infants). Likely igm, igg, and IgA although I am not specific about this. ...Read more
Herpes IgM Immunoglobulin test result - 0.68 gm/l (reference range: 0.4 - 2.4 gm/l), is it positive or negative? Thank you :)
Look again: One should look at the results again. A herpes IgM reference value should be "less than a number" and look something like <1.0 or look like <1:1. The number depends on the lab. If the test result is less than the reference value, then the result means NEGATIVE or no recent infection suspected. The reference value should not be two numbers separated by a dash, so should not look like 0.4-2.4 gm/l. ...Read more
Why is secondary IgM deficiency seen in whipple's disease? I thought infection did not reduce immunoglobulin levels.
Protein-losing Enter: Protein-losing enteropathy is characterized by excessive loss of serum proteins into the gastrointestinal tract. Lymphopenia is a common finding associated with protein-losing enteropathy due to whipple disease. In addition to the loss of albumin, components of lymph are also lost into the bowel, including lymphocytes, immunoglobulins, as well as fat-soluble vitamins, lipids & cholesterol. ...Read more
I have a very high ANA titre (1:2560 homogenous), but normal immunoglobulins (IgG, IgA, and IgM) and normal CRP. Could I still have lupus?
Colostrum is a source of immunoglobulins igG igA igM and gamma interferon. So could this affect HIV test? (Faulse negative)? (or other stds tests?)
It won't: It just won't. Taking colostrum isn't going to improve your health, the antibodies get digested in your gut, and they will not mask the antibodies of disease. If you are interested in this stuff, get an honest evidence-based holistic practitioner. Just getting super-fit in the gym will enhance your immunity far more than this mumbo jumbo ...Read more
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