Doctor insights on:
What Does High Prothrombin Time Mean
Blood clotting: Defective. Prolonged prothrombin time can be due to deficiency of a number of coagulation factors. A common cause it treatment with warfarin/coumdain. Liver disease is an other common reason for prolonged pt. Depending on the prolongation, the person may be at risk of bleeding. Read more
Can mean Vit K low.: If prothrombin time blood test is high, without other high levels, it can mean a vitamin k deficiency or warfarin use. Vitamin k helps in the function and viability of factors ii, vii, ix, and x and these affect prothrombin time. If there are other levels altered, it could be a factor v, or x deficiency, disseminated intravascular coagulation (dic), or liver failure. See your doctor to be sure. Read more
Abnormal clotting: An abnormal prothrombin time means that there is something wrong with your blood's ability to form clots and prevent bleeding. There are many conditions that result in such an abnormality, and you need to have your doctor figure out what the problem is based on other test findings and your symptoms. Sometimes you'll need a hematologist to consult if there is a chance of a serious bleeding problem. Read more
I had an aptt of 36.5, a aptt 1:1 np of 33.3, and a prothrombin time of 13.5. All are listed under high but my doctor is not concerned? Is this ok?
Normal range?: More information is needed including the "normal range" of the tests. Why were the tests ordered? However the elevated aptt corrects with mixing with normal blood (1:1 mix) suggesting a coagulation factor deficiency. Consider repeat testing and asking for more information about cause. Your doctor may seek the opinion of a hematologist. Read more
Daughter has high monocytes, eos, eos absolute, platelets and prothrombin time. What can cause this?
See a hematologist: There are several differentials to be considered. Only a hematologist (a blood specialist) can guide you on the most appropriate next step to find the cause. Looking at the blood under the microscope and reviewing other blood tests as well as physical exam can narrow down the list. Often times, a bone marrow biopsy may be needed. Read more
What can cause my daughter to have high monocytes, eos, eos absolute, platelets and prothrombin time?
Check with doc: Isolated increases in monocytes and eosinophils are often normal, especially if the overall WBC is normal and the patient is not sick. There are many causes for an elevated pro time - typically taking anticoagulants (warfarin, coumadin), some bleeding problems, vit k malabsorption or poor nutrition. If more than 2 seconds above normal have it checked out. Read more
Prothrombin time = 15.8 ses, does that mean I am k deficient? Why does it increase? What are normal values? Hvy periods, fibroid, lysteda, treatment?
INR matters more: Different labs have different standards for prothrombin times. To standardize, labs report a value called "INR." INR of 1 is normal. Elevated INR in the absence of taking warfarin/Coumadin can occur with certain abnormalities of the clotting system, vitamin K deficiency, liver disease (inability to make clotting factors), or may just be within margin of error for the lab & in need of repeating. Read moreSee 1 more doctor answer
Repeat test.: A shortened clotting time that does not appear to reflect technical error has been associated with an increased risk of thrombosis, recurrent thrombosis, recurrent miscarriage, or bleeding, and may increase the risk of thrombosis associated with other common thrombotic risk factors (eg, factor v leiden, obesity, increased levels of d-dimer). Read more
Blood clotting: Thrombocytopenia means low level of blood plateletes. Prothrombin time is a test for extrinsic coagulation pathway that is initiated with factor vii. Vitamin k deficiency or use of Coumadin (warfarin) or liver function deficiency will prolong the prothrombin time, while several blood clotting diseases that affect intrinsic coagulation such as von willibrand or hemophila will not affect prothrombin time. Read more
Depends on: Circumstances. In a normal person, usual drugs and foods do not affect pt measurably. In patients on warfarin, foods both prolong pt, e.g., grapefruit, or shorten it, e.g., green leafy vegetables. Many drugs affect pt, e.g., birth control pills, isoniazid, anti-fungals, antibiotics, and many other drugs metabolized through cytochrome p450 system, and barbiturates and alcohol. Read more
Measures clot factor: This is a test that measures clotting factor activity. All these factors are synthesized in the liver, except factor viii, so this is also a check on the capability of the liver as well. If this is high, it can be from a deficiency or incabability of the factors or a liver failure issue, like cirrhosis, or a vitamin k deficiency from fat malabsorption. This shoud be worked-up dr.'s office. Read more
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