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Doctor insights on: What Does Extremely High Thyroid Peroxidase Mean

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Dr. Herman Hammerstead
13 doctors shared insights

Thyroid (Definition)

The thyroid is an endocrine gland that sits in the lower part of the neck. It produces thyroid hormone - which ...Read more


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What does high thyroid peroxidase mean?

What does high thyroid peroxidase mean?

Depends: If you mean antibodies to thyroid peroxidase, it may suggest auto-immune thyroid disorder. ...Read more

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My thyroid peroxidase antibodiy level is high 1010.8u/ml what does it mean TSH 3 generation 3.39 t4free 1.1 thyroxinet4 9.5 please answer?

My thyroid peroxidase antibodiy level is high 1010.8u/ml what does it mean TSH 3 generation 3.39 t4free 1.1 thyroxinet4 9.5 please answer?

Normal function : It means your thyroid is functioning normally, but you have antibodies against your thyroid. We don't really know why this happens. It does not cause any symptoms. No treatment is needed. You should, however, have your thyroid hormone levels checked once or twice a year because you are at risk of developing thyroid dysfunction. ...Read more

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Is 4IU/ML Thyroid Peroxidase AB considered abnormally high or cause for concern? Free T3 is 2.4PG/ML, does this mean I have hypothyroidism?

Is 4IU/ML Thyroid Peroxidase AB considered abnormally high or cause for concern? Free T3 is 2.4PG/ML, does this mean I have hypothyroidism?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the most useful test for checking thyroid function is TSH level. The normal ranges may vary by the method used and the level should be checked against the reference range of the lab that did the test. ...Read more

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Is there any cure if your thyroid levels are normal but u have extremely high thyroid peroxidase and a goiter with nodules?

Is there any cure if your thyroid levels are normal but u have extremely high thyroid peroxidase and a goiter with nodules?

No cure: However, you have hashimoto's and may become hypothyroid in the future. Have yearly check of the TSH or more frequently if you plan to get pregnant! TSH levels should be under 2.5 – 3.5 non pregnant. "Normal" tshs of 4 or 5 are not normal. ...Read more

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How are high levels of thyroid peroxidase antibody treated (125)tsh (317)ft4(74) is armour thyroid safe im ttc?

How are high levels of thyroid peroxidase antibody treated (125)tsh (317)ft4(74) is armour thyroid safe im ttc?

They aren't: That study indicates the presence of autoimmune thyroid disease. You treat if tests show the presence of low thyroid function. ...Read more

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Thyroid peroxidase antibody level is 200. What does that mean?

Thyroid peroxidase antibody level is 200. What does that mean?

Prior thyroiditis: It means you have had prior thyroiditis at some time in the past. Repeated episodes of thyroiditis can lead to an underactive thyroid in the future. ...Read more

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What does it mean when your ths is 7.160 but your T4 is 1.02 and your thyroid peroxidase is 313?

What does it mean when your ths is 7.160 but your T4 is 1.02 and your thyroid peroxidase is 313?

Hashimotos: It means you have hashimotos thyroid disease, an autoimmune thyroid disease that will cause hypothyroidism. Please see your doctor for thyroid replacement. ...Read more

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My thyroglobulin antibody is <1.0 and thyroid peroxidase (TPO) is<6 what does this mean.

My thyroglobulin antibody is <1.0 and thyroid peroxidase (TPO) is<6 what does this mean.

Good news: It is unlikely that you have Hashimoto's thyroiditis. Many folks have low levels of these antibodies but they tend to be high in folks with this common illness. Best wishes. ...Read more

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Lab tests showed the following: ANA w/titre & pattern 1:320 and a thyroid peroxidase ab 484.0... Could high ANA be because of positive hashimoto's?

Lab tests showed the following: ANA w/titre & pattern 1:320 and a thyroid peroxidase ab 484.0... Could high ANA be because of positive hashimoto's?

No: Hoshimoto's is an autoimmune disease. ANA is elevated in autoimmune diseases. Hoshimoto's doesn't cause the elevated ANA but an autoimmune state cause both the elevated ANA and thyroid antibodies which cause hoshimoto's. ...Read more

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Lab results as follows: ANA w/titre and pattern 1:320 and thyroid peroxidase ab 484.0.... Are the two related? Would hashimoto's cause high ANA level?

Lab results as follows: ANA w/titre and pattern 1:320 and thyroid peroxidase ab 484.0.... Are the two related? Would hashimoto's cause high ANA level?

No: You have an elevated thyroid peroxidase (tpo) antibody because you have a tendency towards autoimmunity. The elevated tpo causes hoshimoto's. The tendency towards autoimmunity causes the high ANA level. ...Read more

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23 yrs old f; thyroid peroxidase 13 (norm); thyroglobulin, antibody 3.0 (high); TSH 10.850 (high); nomal T3 (liothyronine) & t4. Hashimotos? Possible thyroid cancer

23 yrs old f; thyroid peroxidase 13 (norm); thyroglobulin, antibody 3.0 (high); TSH 10.850 (high); nomal T3 (liothyronine) & t4. Hashimotos? Possible thyroid cancer

Possible to 1st : Thyroglobulin is a test that is helpful after someone has surgery for the most common thyroid cancer. Thyroid function tests can test how well your thyroid is working. If there is concern for cancer it is helpful to get a thyroid ultrasound and then a biopsy if clinically indicated. ...Read more

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A blood test has shown thyroid peroxidase ab is 62.8 ku/l does this raise mean I have hashimoto’s?

A blood test has shown thyroid peroxidase ab is 62.8 ku/l does this raise mean I have hashimoto’s?

Not necessarily...: The first question is why was the test done? If because of abn thyroid labs &/or an abn thyroid ultrasound I would be highly suspicious. Although this value is tech elev it is only min so. This COULD be early Hashimoto's, but values with active Hashimoto's are often as high as the thousands. Diff labs also have diff ways of measuring TPO & can give mildly abn values at times. Need more info... ...Read more

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Hi, I just had my blood test results and the thyroid peroxidase ab level is 1122.18 iu/ml. What does that mean? I visited the dr feeling tired

Hi, I just had my blood test results and the thyroid peroxidase ab level is 1122.18 iu/ml.  What does that mean? I visited the dr feeling tired

Important info: B"sd
The TPAb is specific for thyroid peroxidase enzyme. Its occurence is highly related to genetic susceptibilty to Hashimoto's thyroiditis. The most common condition associated with hypothyroidism, occasionaly hyperthyroidism. There is also an increased incidence of thyroid nodules, so in my practise in addition to thyroid function tests, a thyroid US would be done. Glad to discuss further. ...Read more

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What does it mean when thyroid peroxidase antibodies 50.2 IU/mL? Thyroglobulin antibodies 18.0 IU/mL?

What does it mean when thyroid peroxidase antibodies 50.2 IU/mL? 
Thyroglobulin antibodies 18.0 IU/mL?

Not much by itself: Thyroid antibodies are most helpful if you have a low free T4 and a high TSH indicating hypothyroidism which is most often due to autoimmune thyroid inflammation. If those tests are normal you need no treatment but your high antibodies suggest you have an increased risk of developing hypothyroidism somewhere down the road, but many people with antibodies never develop a thyroid problem. ...Read more

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My thyroid peroxidase ab are 1010.8u/ml TSH 3 generation 3.39 T4 free 1.1 thyroxine T4 9.5 what does it mean ttc desperately had 1 miscarriage in june?

My thyroid peroxidase ab are 1010.8u/ml TSH 3 generation 3.39 T4 free 1.1 thyroxine T4 9.5 what does it mean ttc desperately had 1 miscarriage in june?

Thyroid disease: So your TSH should be between 0.5 and 2.5 when trying to conceieve. If the TSH is higher there is a slightly higher risk of abnormal brain development in a child. The antibodies do increase your chance of miscarriage. So care by a specialist would be recommended. ...Read more

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What does it mean to have 91 for THYROID PEROXIDASE ANTIBODIES, <1 for THYROGLOBULIN ANTIBODIES, TSH 4.44, and T3, (liothyronine) TOTAL 72; no symptoms?

What does it mean to have 91 for THYROID PEROXIDASE ANTIBODIES, <1 for THYROGLOBULIN ANTIBODIES, TSH 4.44, and T3, (liothyronine) TOTAL 72; no symptoms?

Hashimoto's thyroid: Have endocrinologist check labs for likely hypothyroid, autoimmune[self immune temporary usually low thyroid], usually transient, will go away, unsure cause. Other labs seem normal so look up hashimotos thyroiditis. Could be other, see dr. ...Read more

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Symptoms ; joint pain & chronic cough.ANA TITER 1:640, C3= 89, RNP +, ASMA =42, Thyroid peroxidase AB= 663, liver enzymes elevated. Help?

Symptoms ; joint pain & chronic cough.ANA TITER 1:640, C3= 89, RNP +, ASMA =42, Thyroid peroxidase AB= 663, liver enzymes elevated.  Help?

Autoimmune disorder: With this profile, you clearly have an autoimmune disorder. The manifestations can be very targeted or diffuse. Autoimmune diseases include lupus, Goodpasture's syndrome, psoriasis and psoriatic arthritis, juvenile arthritis, Sjogren's syndrome, autoimmune hepatitis and primary biliary cirrhosis. See your doctor ASAP, this can be treated before organ damage is irreversible. Good luck. ...Read more

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I had a thyriod test and my thyroid peroxidase reading was 60.6 is there a chance that I could have hashimotos.?

Autoimmune thyroid: Hashimoto's disease is autoimmune condition where immune system attacks own thyroid gland with antibodies (abs) and white blood cells. This eventually leads to damage in thyroid gland and inadequate thyroid hormone production. The earliest blood test that diagnoses hashimoto disease is high levels of abs such as anti-thyroid peroxidase or anti-thyroglobulin abs, even before thyroid hormone is low. ...Read more

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What are thyroid peroxidase antibodies?

Thyroid antibody: They are made by your own wbcs directed against peroxidase, an enzyme on the thyroid microsome. People with hashimoto's and graves' diseases may have + antibodies to the thyroid peroxidase. ...Read more

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What are the normal thyroid peroxidase antibodies?

What are the normal thyroid peroxidase antibodies?

Usually very low: Tpo antibodies are generally low or absent unless you have had hashimoto's thyroiditis. Once they occur, they may decline slowly or last a lifetime. ...Read more

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What is the definition or description of: thyroid peroxidase antibodies?

Thyroperoxidase(TPO): The body uses antibodies to attack and remove foreign substances.
Useful as an aid in the diagnosis of thyroid autoimmune disorders; differentiating thyroid autoimmune disorders from nonautoimmune goiter or hypothyroidism; as a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism. ...Read more

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Regarding thyroid peroxidase antibodies, if I am positive, should my kids all be checked?

Regarding thyroid peroxidase antibodies, if I am positive, should my kids all be checked?

No.: Anti tpo ab are not inherited directly. If your child develops signs and symptoms of hypothyroidism it might be reasonable to check a tsh, but not tpo. ...Read more

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In my laboratory result Fe is 172and anti thyroid peroxidase is 104.1. Is it good or not?

In my laboratory result Fe is 172and anti thyroid peroxidase is 104.1. Is it good or not?

Reference range: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your iron is normal. What is the normal (reference) range for anti-thyroid peroxidase in the lab that did the test? It may need additional investigation.
For good health — Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Thyroid peroxidase ab results 96 all other levels normal do I have hypothyroidism?

Thyroid peroxidase ab results 96 all other levels normal do I have hypothyroidism?

No: Tpo ab's do not diagnose hypothyroidism. Only thyroid function tests (free t4, tsh) can do that. If you don't have hypothyroidism, why are you on levothyroxine? If you do have hypothyroidism and need t4, make sure it's brand name medication as the generics are unreliable. ...Read more

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My thyroid peroxidase level was 111 in march and now is at 144, what do I do and what is the problem, I am on levothyroxine .88 mg?

My thyroid peroxidase level was 111 in march and now is at 144, what do I do and what is the problem, I am on levothyroxine .88 mg?

Thyroid antibodies: The presence of anti-thyroid peroxidase antibodies signals the presences of autoimmune thyroid disease. This is often, but not always, associated with underactivity of the thyroid. The change in level of the antibodies does not have any real significance; what is important is that your dose of thyroid hormone replacement results in your having a normal TSH level. ...Read more