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Doctor insights on: What Does Ca125 Come From

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Where does ca125 originate?

Where does ca125 originate?

In the peritoneal li: It arises from the irritation or growth of peritoneal lining cells. These cells also cover the ovaries. So ca 125 is often used as a test to screening for ovarian cancer. But it often raised in any conditions causing intra -abdominal irritation like in peritonitis. ...Read more

Dr. John Landi
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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What if your ca125 test is 125?

What if your ca125 test is 125?

Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps. ...Read more

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Certain food affect ca125 tests?

Not likely: Ca 125 test looks for a particular glycoprotein in blood and diet is not likely to affect the results. ...Read more

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What are the functions of ca125?

Part of cell surface: Ca125 is a component of mucin, mucous like material on the surface of cells that provides lubrication and is a barrier to foreign invaders. It is found on many different types of cells, including the female organs. It is shed from tumor cells in ovarian cancer, and therefore can be measured in blood as a tumor marker, but since ca125 is on many other kinds of cells, it is not specific. ...Read more

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What is the definition or description of: ca125?

CA125 Definition: Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast et al. In 1983. ...Read more

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How concerned should I be if my ca125 level was not ordered this year?

How concerned should I be if my ca125 level was not ordered this year?

None to minimal: If the ca-125 was going to be used simply as another blood test for example in a yearly physical, you should not be terribly concerned at all. My answer is different however, if you have a history of a disease such as ovarian cancer and that it should be checked. I also might order it if you have a strong family history of ovarian cancer for example. If not you should not be concerned. ...Read more

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Ca125 level is a marker for which tumor?

Ovarian: It is neither sensitive nor specific for screening. However, its recurrence after removal of a tumor that produces it suggests recurrence. ...Read more