Doctor insights on:
What Does Brca Stand For
Breast cancer: BRCA refers to a set of genes that have been associated to confer a higher risk of developing certain cancers. It was first identified in women with a higher risk of developing breast cancer hence the acronym BRCA. It is associated with breast cancer, ovarian cancer and peritoneal cancer. It can be associated with breast cancer in males as well. ...Read moreSee 2 more doctor answers
Mutation=cancer risk: People with mutations in the brca1 or brca2 gene are at higher risk of developing certain cancers. With a mutation, the lifetime risk of breast cancer is 41 to 90%, and ovarian cancer is 8 to 62%. Pancreatic and prostate cancer are more common as well. If you are a woman and test positive, you will have to consider having your ovaries and breasts removed. Genetic counseling is key! ...Read moreSee 1 more doctor answer
Genetic Counseling: Have you met with a genetic counselor? If not, i strongly recommend this. Testing brca-2 (+) puts you at an increased risk for breast and ovarian cancer (as well as ca of the stomach, pancreas, gallbladder, bile ducts, and melanoma). Options include surgical prophylaxis (mastectomy, oophorectomy), chemoprevention, and close surveillance. These decisions are best made with a professional. ...Read moreSee 2 more doctor answers
No: It's not the test that's the big deal, it's what one does with the information. Understanding what a positive and negative test means and what the decision options based on each are something that should be discussed and planned for before testing is sent. Without knowing family genetic status a neg. Test may not mean much. Thus, testing should start with an affected indiv. 1st if possible. ...Read moreSee 2 more doctor answers
Risk reduction: The "best" option is a personal choice. Options to lower breast cancer risk for patients with a BRCA1 or BRCA2 mutation include: -bilateral mastectomy which removes most but not all of the breast cells, and reduces risk the most (by 90-95%) -breast MRI and mammogram does not reduce risk but finds breast cancer early when it is more treatable -chemoprevention to prevent getting breast cancer ...Read moreSee 2 more doctor answers
My 34yr sister had brca1and2 testing.Her brca 2 sequencing back positive as "likely pathogenic".What does that mean?Negative for brca 1 sequenc/depdup
What does angelina jolie's brca test, double mastectomy and oophorectomy mean for the average woman?
For the AVERAGE...: ...Risk woman, it should create awareness about: getting routine screening, knowing your family history well, and living a healthy lifestyle. It should not: make people want genetic tests without reason or make women ask for mastectomies out of fear. Of course, it is important to know if your risk is average or high in order to make the right decisions. Talk to your gyn about this. ...Read moreSee 2 more doctor answers
It is an option...: ...But not the only one. Any person with an inherited cancer trait or a strong family history of cancer should discuss their management with a specialist in cancer genetics. No such thing as one size fits all. Good news is that by knowing you have a mutation, you have the tactical advantage. Best to you. ...Read moreSee 2 more doctor answers
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