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Doctor insights on: What Does An Elevated Lipase And Amylase Mean

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Dr. Arthur Heller
Board Certified, Gastroenterology
37 years in practice
17M people helped
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What does an elevated lipase and amylase mean?

What does an elevated lipase and amylase mean?

Can be pancreas infl: Amylase: enzyme made by pancreas and salivary glands. Elevation can be seen with pancreatitis, mumps, vomiting/bulimia sometimes with other GI (gallbladder, ulcer), gyn issues. Lipase is a somewhat more specific pancreatic enzyme. Mild elevations non specific, very high more specific marker of pancreatic inflammation. Kidney disease screws up the values. Incr. In cystic fibrosis, celiac, . ...Read more

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Dr. Christopher Crosby
Board Certified
10 years in practice
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Dr. Todd Igel
313 doctors shared insights

Lipase (Definition)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of ...Read more


Dr. Cheryl Moore
Board Certified, Pathology
28 years in practice
12K people helped
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What does it mean to have elevated conjugated bilirubin but normal total bilirubin? And if it is together with high amylase and borderline lipase?

What does it mean to have elevated conjugated bilirubin but normal total bilirubin? And if it is together with high amylase and borderline lipase?

Gallbladder/pancreas: High amylase with increased lipase can indicate pancreatitis. High conjugated bilirubin indicates hepatobiliary disease. You should go see a gastroenterologist with your lab results. ...Read more

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Dr. Christopher Crosby
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Dr. Gerald Mandell
Board Certified, Nuclear Medicine
46 years in practice
4M people helped
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What do you suggest if my sister has elevated lipase and amylase. nauseated, no appetite. platelets low. so far MRI of pancreas norm?

What do you suggest if my sister has elevated lipase and amylase. nauseated, no appetite. platelets low. so far MRI of pancreas norm?

Pancreatitis?: Sometimes imaging lags behind acute disease process. Sounds like pancreatitis. Doctor should treat symptoms and patient not the images.Etiology of pancreatitis needs to be worked out. ...Read more

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Dr. Myron Arlen
Board Certified, Surgical Oncology
58 years in practice
2M people helped
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My sister has elevated lipase and amylase. nauseated, no appetite. platelets low. so far MRI of pancreas is normal. What could be the problem?

Many sources: While lipase and amylase are produced for the most part by the pancreas, an elevation is usually a result of inflammation of pancreatic tissue . If the condition is not severe the scans may fail to detect changes in the gross structure of the pancreas Other organs however are associated with an elevated amylase such as the fallopian tubes and lipase is known to be be produced in mature and immature adipocytes, muscle cells, and mammary epithelial cells . The clinical condition should be followed and if symptoms progress, then reevaluation should be considered ...Read more

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Dr. Christopher Crosby
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Dr. Gurmukh Singh
Board Certified, Pathology
43 years in practice
95M people helped
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What does "amylase is more sensitive and lipase test is more specific" mean?

See below:: Amylase is elevated more often in patients with panreatitis, but elevated amylase, unless substantially high does not mean pancreatitis. When lipase is elevated the person is more likely to have pancreatitis. See this site for general explanation of these terms http://gim.Unmc.Edu/dxtests/reviewof.Htm. ...Read more

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Dr. Joseph Rank
Board Certified, Pathology
92K people helped
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What does it mean if your amylase and lipase are high?

What does it mean if your amylase and lipase are high?

Pancreatitis: Amylase and lipase are both enzymes that can be detected in the blood in the setting of pancreatitis. With inflammation or injury to the pancreas, these enzymes are "leaked" and get in to the blood. ...Read more

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Dr. David Krulak
Board Certified, Family Medicine
17 years in practice
1M people helped
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What % of chronic or acute pancreatitis shows elevated Lipase or Amylase?

Acute tests: A 1998 study found that 100% of patients with acute pancreatitis had an elevated lipase, and 95% had an elevated amylase directly upon admission to the hospital. As their hospitalization continued, those values dropped off and so the tests would be less useful for diagnosis. ...Read more

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Dr. Gurmukh Singh
Board Certified, Pathology
43 years in practice
95M people helped
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Can you have pancreatitis with normal blood test levels? Or will lipase and amylase be elevated? How would it be diagnosed?

Amylase and: lipase are elevated in pancreatitis. If the blood levels of these enzymes are normal, you do not have panreatitis. See this site for more info. http://www.mayoclinic.org/diseases-conditions/pancreatitis/basics/definition/con-20028421 ...Read more

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Dr. Ed Friedlander
Board Certified, Pathology
38 years in practice
136M people helped
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Can you have acute or chronic pancreatitis without elevated lipase or amylase results in labs?

Chronic: Even in acute pancreatitis, these labs are unreliable, there is the possibility of lab error. Chronic pancreatitis is really more about scarring and injury to nearby structures rather than ongoing tissue damage, and amylase and lipase are usually normal. ...Read more

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Dr. Daniel Rychlik
131 doctors shared insights

Amylase (Definition)

An enzyme produced by either the panceas or the salivary glands that aid is the ...Read more


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Dr. Christopher Crosby
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