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Doctor insights on: What Does An Ana Genetic Marker Mean

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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AM 19 having recurrent acute pancreatitis idiopathic and doc said to do ANA profile. test and genetic mutations test WILL THEY HELP.

AM 19 having recurrent acute pancreatitis idiopathic and doc said to do ANA profile. test and genetic mutations test WILL THEY HELP.

Yes: Hereditary pancreatitis occurs as a mutation in a gene on chromosome 7. It will require follow up and family checking if found. Recurrent pancreatitis can also be autoimmune and also be associated with autoimmune diseases and finding one would influence management. Very important to do at your age. ...Read more

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Ana marker of 1.32 what does it mean, I have had it checked twice over the past 3 months and it has stayed the same. No symptoms excepts crampy hands?

Ana marker of 1.32 what does it mean, I have had it checked twice over the past 3 months and it has stayed the same. No symptoms excepts crampy hands?

Possibly nothing: This is a low concentration of ANA and oftentimes has no clinical meaning. It really ddepends on what symptoms and other findings there are. Crampyness in the hands is not usually related to any of the dieases associated with a positive ana. Often, it may take long peiords of time for other symprtoms to develop. Need to keep watch. ...Read more

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What does it mean to have 3 out of 6 genetics markers when getting test results as a kidney donor?

What does it mean to have 3 out of 6 genetics markers when getting test results as a kidney donor?

Variable: Hla antigens are a major factor that drives the rejection response to transplant organs. Matching refers to the number of hla antigens identified in recipients and donors; and how many are the same. Commonly six antigens; two for hla a, two for hla b, and two for hla dr are typed matched for kidney transplant. So a 3/6 match means half the hla antigens are the same. ...Read more

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What does it mean to have 3/6 genetics markers when getting test results for being a kidney donor?

What does it mean to have 3/6 genetics markers when getting test results for being a kidney donor?

That u r a 1/2 match: We each inherit one set of three human leukocyte antigens (hla) from each parent; thus, we each have 6 of these. The more hla matching between donor and recipient of the kidney, the closer the match, the less likely is rejection and less anti-rejection drugs need be used. The best match is 6/6, the worst is 0/6. A half match is 3/6 genetic markers=possible donor. Transplant team will decide. ...Read more

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Can a positive ANA (going up for years, now 1/640) be insignificant if other autoimmune markers are negative?

Can a positive ANA (going up for years, now 1/640) be insignificant if other autoimmune markers are negative?

Probably not: If you don't have symptoms but why are they checking it?? Ask the person who ordered it to be sure. They know you and your history . ...Read more

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My ANA was positive but no other markers of autoimmune disease were found. Also non specific elevateKappa free light chain which is also non specific.

Non-diagnostic: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings you described are not diagnostic of any illness. These and any other test results need to be evaluated in the context of your symptoms and findings on physical examination. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Started me on plaquenill due to symptoms (no dryness)low positive ana. He mentioned markers for sjogrens then he spoke of lupus.Gave no diagnose?

see details: What symptoms do you actually have? Without this information, it is impossible to answer. If it is just GI issues, get another opinion. Plaquenil, (hydroxychloroquine) however, is commonly used as a first-line agent to treat lupus. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


Marker (Definition)

A "marker" is a protein or enzyme that can represent a disease process. Some markers are specific for a particular disease, while ...Read more