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Doctor insights on: What Does An Ana Genetic Marker Mean

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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AM 19 having recurrent acute pancreatitis idiopathic and doc said to do ANA profile. Test and genetic mutations test WILL THEY HELP.

AM 19 having recurrent acute pancreatitis idiopathic and doc said to do ANA profile. Test and genetic mutations test WILL THEY HELP.

Yes: Hereditary pancreatitis occurs as a mutation in a gene on chromosome 7. It will require follow up and family checking if found. Recurrent pancreatitis can also be autoimmune and also be associated with autoimmune diseases and finding one would influence management. Very important to do at your age. ...Read more

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Ana marker of 1.32 what does it mean, I have had it checked twice over the past 3 months and it has stayed the same. No symptoms excepts crampy hands?

Ana marker of 1.32 what does it mean, I have had it checked twice over the past 3 months and it has stayed the same. No symptoms excepts crampy hands?

Possibly nothing: This is a low concentration of ANA and oftentimes has no clinical meaning. It really ddepends on what symptoms and other findings there are. Crampyness in the hands is not usually related to any of the dieases associated with a positive ana. Often, it may take long peiords of time for other symprtoms to develop. Need to keep watch. ...Read more

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What does it mean to have 3 out of 6 genetics markers when getting test results as a kidney donor?

What does it mean to have 3 out of 6 genetics markers when getting test results as a kidney donor?

Variable: Hla antigens are a major factor that drives the rejection response to transplant organs. Matching refers to the number of hla antigens identified in recipients and donors; and how many are the same. Commonly six antigens; two for hla a, two for hla b, and two for hla dr are typed matched for kidney transplant. So a 3/6 match means half the hla antigens are the same. ...Read more

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What does it mean to have 3/6 genetics markers when getting test results for being a kidney donor?

What does it mean to have 3/6 genetics markers when getting test results for being a kidney donor?

That u r a 1/2 match: We each inherit one set of three human leukocyte antigens (hla) from each parent; thus, we each have 6 of these. The more hla matching between donor and recipient of the kidney, the closer the match, the less likely is rejection and less anti-rejection drugs need be used. The best match is 6/6, the worst is 0/6. A half match is 3/6 genetic markers=possible donor. Transplant team will decide. ...Read more

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Can a positive ANA (going up for years, now 1/640) be insignificant if other autoimmune markers are negative?

Can a positive ANA (going up for years, now 1/640) be insignificant if other autoimmune markers are negative?

Probably not: If you don't have symptoms but why are they checking it?? Ask the person who ordered it to be sure. They know you and your history. ...Read more

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My ANA was positive but no other markers of autoimmune disease were found. Also non specific elevateKappa free light chain which is also non specific.

Non-diagnostic: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings you described are not diagnostic of any illness. These and any other test results need to be evaluated in the context of your symptoms and findings on physical examination. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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What is the gold standard test for sjorgens. Had high ana's in the past and then they were ok, then high, Inflammatory markers usually normal.?

Antibody and dryness: Diagnosis of Sjogrens requires more than one condition to be satisfied. One being antibody markers and the other being dryness of eyes and mucus membranes. You may consult this site for more info: http://www. Mayoclinic. Org/diseases-conditions/sjogrens-syndrome/basics/tests-diagnosis/con-20020275 Wish you good health! ...Read more

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Started me on plaquenill due to symptoms (no dryness)low positive ana. He mentioned markers for sjogrens then he spoke of lupus. Gave no diagnose?

See details: What symptoms do you actually have? Without this information, it is impossible to answer. If it is just GI issues, get another opinion. Plaquenil, (hydroxychloroquine) however, is commonly used as a first-line agent to treat lupus. ...Read more

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What is the implication of high homogenous ANA 1:320 with other markers normal. Autoimmune or connective tissue disease suspected but not confirme?

See details: The ANA may be the only positive autoantibody in some patients with lupus. The ANA must always be evaluated in the context of the clinical picture. ...Read more

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What is the likelihood that lupus or sjogrens is causing lbs like and autoimmune symptoms? Chrons has been ruled out. Low pos ANA and sjogrens markers

What is the likelihood that lupus or sjogrens is causing lbs like and autoimmune symptoms? Chrons has been ruled out. Low pos ANA and sjogrens markers

Unlikely: Though there may be an issue with small bowel bacterial overgrowth (sbbo) in individuals with lupus/sjogrens (conjecture -- no data or studies substantiating this). Sbbo may mediate ibs related symptoms. ...Read more

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Should my identical twin sister be tested for DNA because I have inflammatory markers and postive ANA antibody test?

Should my identical twin sister be tested for DNA because I have inflammatory markers and postive ANA antibody test?

It's her call: It sounds like a search for lupus. If you do turn out to have lupus, it's way below even-money that your identical twin will ever be affected, there's little to be gained from early diagnosis, if she develops symptoms she has the heads-up. The antibodies do appear several years before the illness if she is very curious. ...Read more

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Why might all inflammatory markers be negative during lupus flare? I do have consistent ANA of 1:640 though. Prednisone helps my recurring flares.

Why might all inflammatory markers be negative during lupus flare? I do have consistent ANA of 1:640 though. Prednisone helps my recurring flares.

ANA: no correlation!: There is no correlation with ANA titer and lupus flares! There is with anti-dna antibodies, and various other tests including c2, c4, lymphocyte count. Sle does not raise CRP for unknown reasons! Discuss this rheumatology issue with your rheumatologist or pcp. Irrespective of Prednisone helping flares, you should be on plaquenyl which prevents flares! ...Read more

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Ana positive 160 poss mtcd w/o lupus markers. What can cause 300 mg/dL lambda 200 lambda if no paraprotein? Check igd/e? Urine spot lambda bjp found

BJP: Bence Jones proteins, light chain, occur in multiple myeloma, lymphomas/chronic leukemias, monoclonal gammopathy of undetermined significance which can go on to myeloma at the rate of only 1%/yr -small risk), amylodosis, cryoglobunemia, Autoimmune disease can give false positive. Check IFE & bone marrow http://www. Livestrong. Com/article/372234-about-multiple-myeloma-and-bence-jones-protein/ ...Read more

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Are fevers common in pots? Been getting almost daily low fevers of 99.5-100.5 for 6 weeks. Wbc, ANA and inflammatory markers normal. Doc has no idea if normal for pots.

Are fevers common in pots? Been getting almost daily low fevers of 99.5-100.5 for 6 weeks. Wbc, ANA and inflammatory markers normal. Doc has no idea if normal for pots.

No. Fevers abnormal.: Pots should not give you a fever everyday. Perhaps you and your doctor need to take a fresh look at everything. Maybe the fevers are unrelated, but maybe they are related to your hypotension and what you have is something other than pots. ...Read more

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I had ANA 1:160+, ESR 29 CRP 0.1 autoantibodies show ssa of 8 (0-40 is neg) and scl-70 ENA ab of 3 (0-40 is neg) wouldn't this be scleroderma? Not lupus? Why would lupus patient have scl-70 markers?

Not just antibodies: If the scl-70 titer is 3, as you wrote, it falls within the normal range and is not positive. More importantly, scleroderma is not diagnosed on the basis of antibody studies, but rather clinical findings such as skin thickening, raynaud's phenomenon, lung fibrosis, or pulmonary hypertension. A certain percentage of scleroderma patients are even negative for ana. ...Read more

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When you have a speckled ANA what does that mean?

Need more info: What is the titer of the ana? Without knowing that, no one can answer. Once again, remember that the ANA must be interpreted in the context of the clinical picture. Resubmit your question and provide enough data so someone can give you an answer. ...Read more

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What does homogeneous and atypical speckled ANA mean?

See details: The titer is more important than the pattern. Without knowing the symptoms that led to the test being ordered, it is impossible to answer your question. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


Marker (Definition)

A "marker" is a protein or enzyme that can represent a disease process. Some markers are specific for a particular disease, while ...Read more