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Doctor insights on: What Does An Abnormal Protein Band 1 Mean On Electrophoresis

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What does an abnormal protein band 1 mean on electrophoresis?

What does an abnormal protein band 1 mean on electrophoresis?

Bone marrow disorder: It means that you are making too much of a single antibody or just a part of an antibody because one clone of plasma cells from your bone marrow has developed over the normal population. This can be a benign condition for many years or progress into a condition called multiple myeloma that needs treatment. ...Read more

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Electrophoresis (Definition)

Elecrophoresis is a process of running an electrical current through a matrix and separating items based on how fast they move through the matrix. Frequently in science and medicine, proteins or dna/rna is separated on gel based on the ...Read more


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What does a high alpha 1 protein electrophoresis mean?

What does a high alpha 1 protein electrophoresis mean?

Inflammation: Serum protein electrophoresis is a test that examines specific proteins in the blood, serum Albumin and alpha-1, alpha-2, beta, and gamma globulins. In the alpha-1 zone, alpha-1 antitrypsin (aat) is the major protein, which is involved in neutralizing enzymes secreted by inflammatory cells. Aat is increased in acute inflammation. ...Read more

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Serum protein electrophoresis - hight beta fraction, what does this mean?

Serum protein electrophoresis - hight beta fraction, what does this mean?

Unimportant: Tell us your values of all proteins. The only two that matter are Albumin and Gamma Globulin. A M spike(monoclonal peak) can be abnormal...so look for this, otherwise you are ok and can ignore the beta fraction. ...Read more

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I've had an electrophoresis test done, serum & urine. Results show a spike in the beta and gamma regions. No monoclonal protein. What does this mean? I have proteinuria and fsgs stage 3. I am 50

I've had an electrophoresis test done, serum & urine. Results show a spike in the beta and gamma regions. No monoclonal protein. What does this mean? I have proteinuria and fsgs stage 3. I am 50

What is FSGS?: Please do not use abbreviations....They mean different things to different people. Ask your doctor to advise you about any relationship of your electrophoresis report to your underlying problem. I do not think this report is of any consequence or concern. ...Read more

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What could cause high protein electrophoresis urine .21 G/L?

What could cause high protein electrophoresis urine .21 G/L?

Unclear question: Do you have high protein in the urine? If the protein concentration in urine is 0.21 gm/dL, that warrants an investigation of the kidney function. If you are diabetic, it is all the more important that you consult your doctor, even though protein in urine by itself warrants seeing your doctor. ...Read more

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In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read more

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What does a high alpha 2 protein electrophoresis indicate?

Nothing Particular: It is one of those changes which has no clear cut medical implications. You can ignore it and you would not have to think about it or anything serious that I can medically relate it to. Good like ...Read more

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Does protein electrophoresis serum help to rule out lymphoma?

Does protein electrophoresis serum help to rule out lymphoma?

No: Basically worthless. You're way too young for myeloma. Matt, you've been concerned about lymphoma for months. You're a smart guy at your mental and physical peak. There must be some bold, decisive actions you can take, with good guidance, to make your life better and more fulfilled, so that these concerns won't torment you. You deserve better. Best wishes. ...Read more

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What is the difference in the utility of these 2 tests: IgG subclass (1-4) serum blood test.......And......Serum protein electrophoresis?

What is the difference in the utility of these 2 tests:  IgG subclass (1-4) serum blood test.......And......Serum protein electrophoresis?

Proteins: Igg is an immunoglobulin produced in the body to defends us from infection and inflammation, it is subdivided in 4 subclasses which all have different fucntions, the serum protein electrophoresis is going to measure the distribution of proteins in the blood to determine if there is an abnormal protein production. ...Read more

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Moms blood protein high@ 8.5g/dl (8.3 upper limit). Alb ok. Glob@ upper limit of normal. A/G ratio low@ .8 (1.1-2.2). Low iron,high ferritin. Hgb low@ 12g/dl (12.5-16). eGFR 59. Can biopsy-proven chronic gastritis explain? Push for electrophoresis?

Moms blood protein high@ 8.5g/dl (8.3 upper limit). Alb ok. Glob@ upper limit of normal. A/G ratio low@ .8 (1.1-2.2). Low iron,high ferritin. Hgb low@ 12g/dl (12.5-16). eGFR 59. Can biopsy-proven chronic gastritis explain? Push for electrophoresis?

Repeat labs: All of the abnormal labs there are borderline. None of them seem to stand out as a major problem. I think if she has a diagnosis of gastritis, and it is being treated, it would be OK to wait a few weeks and redraw her blood work to see if it is still abnormal. Good luck to both of you. ...Read more

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I had normal serum protein electrophoresis. Alpha-1-globulin is 0.25 (0.17 - 0.50 g/dl). Low end of normal? Do i need to test for alpha1-antitrypsin?

I had normal serum protein electrophoresis. Alpha-1-globulin is 0.25 (0.17 - 0.50 g/dl). Low end of normal? Do i need to test for alpha1-antitrypsin?

No: Don't bother. What would you do with a result? I'm going to assume that you are a non-smoker and that at age 31 your exercise tolerance is like your peers. You're probably not a candidate for pricey, inconvenient replacement. ...Read more

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Doesn't immunofixation test for the same things as protein electrophoresis and even more than protein electrophoresis?

It is not same test: Serum protein electrophoresis(spe) is a screening test for myeloma and other paraproteinemias it simple shows the abnormal(m) protein peak. Immunofixation is the next best test which provides a lot more additional information like the type of immunoglobulin which is causing the m spike and it will also tell us more useful info about further quantitation of the m peak and subtyping of your disease. ...Read more

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Is a IgG quantitative test same as the serum protein electrophoresis test?

Blood tests: They are two different separate blood tests, spep serum protein electrophoresis test is a screening test for plasma cell disorders like mgus, smoldering or full blown myeloma and quantitative igg is a blood test to quantify the amount of igg in blood. Usually more than 3 grams is significant in blood. ...Read more

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Will the serum protein electrophoresis test tell me anything that the immunofixation test would not tell me?

Yes.: The ife is very sensitive at finding an abnormal antibody (monoclonal antibody) in blood, but it does not measure the quantity. The spep is less sensitive at finding the monocloprotein protein, but it is a quantitative test, so it answers "how much" monoclonal protein is present. The spep is used to monitor therapy for that reason. ...Read more

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Doc wants to do protein electrophoresis test. Globulin always low and a/g always high. Could globulin just be low due to my igg3 deficiency, though?

Doc wants to do protein electrophoresis test.  Globulin always low and a/g always high.  Could globulin just be low due to my igg3 deficiency, though?

Globulin: Globulin production affects immunoglobulin production, hence your low igg3 is a result of your low globulin level and this needs to be investigated. Your doctor is right. ...Read more

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Had bloodwork and urine test don't know what immunofix electrophoresis gel ( IFE) no Monoclonal proteins&IFE paraprotein urine not detected( MGU) HELP?

It means: Your tests were essentially negative!!! What was your Doctor evaluating you for?? anemia>> Bone Pain??? Bone abnormalities on scan/xray??? Ask ? again More info please Dr Z ...Read more

Protein (Definition)

Proteins are large molecules made up of a smaller class of molecules called amino acids. Proteins play an enormous role in the function of our bodies including enzymes, messengers, replicating dna, ...Read more