Top
20
Doctor insights on: What Does A Serotonin Reuptake Inhibitor Do

Share
1

1
What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


2

2
I know that GABA inhibits release of dopamine, but what does glutamate do for dopamine? Precisely what would inhibition of NMDA do to dopamine?

I know that GABA inhibits release of dopamine, but what does glutamate do for dopamine? Precisely what would inhibition of NMDA do to dopamine?

Glutamate: Glutamate is an excitatory neurotransmitter so would turn things on. Gaba is an inhibitory neurotransmitter an therefore turns things off nmda are channels in the brain for glutamate. Blocking the channels can calm things down magnesium is a nmda blocker. ...Read more

3

3
What is a gaba reuptke inhibitor?

What is a gaba reuptke inhibitor?

Anti-convulsant: Some drugs that are used to treat seizures are GABA reuptake inhibitors. GABA is an inhibitory neurotransmitter and has an anti-seizure effect. These drugs reduce the reuptake of GABA into neurons and glia thereby increasing the amount of GABA available to interact with GABA receptors. ...Read more

4

4
How does strattera (atomoxetine) help for ADHD if it is a norepinephrine reuptake inhibitor , without affecting dopamine ?

How does strattera (atomoxetine) help for ADHD if it is a norepinephrine reuptake inhibitor , without affecting dopamine ?

Don't know!: If straterra is a norepinephrine reuptake inhibitor it increases the norepinephrine level in the brain. Methylphenidate stimulants, used in adhd work that way. In my opinion, straterra which was initially unsuccessfully marketed as an antidepressant is not a first line choice for adhd. ...Read more

5

5
How does Buspar (buspirone) help anxiety? Does it raise serotonin like an SSRI antidepressant?

How does Buspar (buspirone) help anxiety? Does it raise serotonin like an SSRI antidepressant?

Uniquely: Actually it it thought to restrain the effects of too much serotonin. It's complicated but the simple answer is NO - it does not work like an SSRI - nor other anti-anxiety drugs. Here's info but also ask your Dr and/or druggist. http://www.healthieryou.com/mhexpert/exp1041502a.html Best! ...Read more

6

6
What p450 enzymes are inhibited/induced by seroquel, (quetiapine) and what does a dopamine/norepinephrine antagonist do? Reduce dopamine levels? Specifics please?

What p450 enzymes are inhibited/induced by seroquel, (quetiapine) and what does a dopamine/norepinephrine antagonist do? Reduce dopamine levels? Specifics please?

Neither: Seroquel (quetiapine) passes through the cyp450 3a4 pathway & is extensively metabolized, but it neither inhibits nor induces the pathway itself. On the other hand, it's metabolism may be significantly affected by other medications. For instance, Dilantin induces the pathway causing seroquel (quetiapine) to be rushed through the pathway, leading to less-effective, lower blood levels. Antagonists are blockers. ...Read more

See 1 more doctor answer
7

7
How does lyrica (pregabalin) work? Is it similiar to narcotic pain medicine? Or similiar to tramadol as norepinephrine and serotonin reuptake inhibitor?

How does lyrica (pregabalin) work? Is it similiar to narcotic pain medicine? Or similiar to tramadol as norepinephrine and serotonin reuptake inhibitor?

Lyrica (pregabalin): Dear pika89800 lyrica enhances gaba in the brain and suppresses pain at a cortical level, pain has 3 main levels, local, spinal and brain (cortex), it is non narcotic, it is an antiseizure medication and can sometimes help both pain and anxiety the answer is purely for educational purposes, please contact your md. ...Read more

8

8
What does it mean " Prozac (fluoxetine) is activating" compared to other ssri?

What does it mean " Prozac (fluoxetine) is activating" compared to other ssri?

Stimulating: Ssris are all similar in how they work, but they vary in how "activating" or "stimulating" they are. A more activating ssri like Prozac can be caffeine-like: gives more energy but makes it hard to sleep. While all ssris can help anxiety, i tend to prefer less activating ones for this problem, as activation may temporarily worsen the feeling of anxiety. Less activating: paxil, (paroxetine) lexapro, celexa. ...Read more

See 2 more doctor answers
Dr. Andrew Ho Dr. Ho
2 doctors agreed:
9

9
Gaba levels, the brain's primary inhibitory neurotransmitter, what does it actually do?

Dr. Andrew Ho Dr. Ho
2 doctors agreed:
Gaba levels, the brain's primary inhibitory neurotransmitter, what does it actually do?

GABA receptor: Like many ligands, gaba binds to its specific receptor, the gaba receptor (with several subtypes). Depending on the location of the gaba receptor, binding of gaba modulates various signaling pathways in the body. Note that gaba receptors are also found in organs outside of the brain. ...Read more

10

10
When should someone take selective serotonin re-uptake inhibitors?

When should someone take selective serotonin re-uptake inhibitors?

Depression: These medications are usually a first line medication for depression although they have other uses. ...Read more

11

11
Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

I'm curious: Why do you believe you need to take medication that claims to affect dopamine, especially OTC remedy which will NOT cross the brain-blood barrier? If you are depressed, you could see a psychiatrist, and if you have Parkinson's disease, a neurologist. ...Read more

12

12
What is snri and how does it work? What drugs are in this class? Is tramadol an snri? What is seratonin syndrome? Do these treat depression and pain?

What is snri and how does it work? What drugs are in this class? Is tramadol an snri? What is seratonin syndrome? Do these treat depression and pain?

SNRI: Snri = serotonin norepinephrine reuptake inhibitor. Effexor, pristiq, meridia, savella (milnacipran), (milnacipran) and Cymbalta are in this class. Tramadol is not. When serotonin and norepinephrine are not taken back up into the neuron, they are more available in the synaptic cleft between neurons. Cymbalta & savella (milnacipran) treat fibro pain; the others more for depression. Cymbalta can treat depression; savella (milnacipran) perhaps less so. ...Read more

13

13
What happens if I take Zoloft and a mao inhibitor like marplan, nardil, and parnate (tranylcypromine)?

What happens if I take Zoloft and a mao inhibitor  like marplan, nardil, and parnate (tranylcypromine)?

Contraindicated: Taking a monoamine oxidase inhibitor (maoi), such nardil, marplan, or Parnate (tranylcypromine) with a serotonin selective reuptake inhibitor (ssri) such as zoloft is contraindicated. When taken together they can lead to serotonin syndrome. This potentially deadly syndrome may cause agitation or restlessness, fast heart beat, hallucinations, increased body temperature, loss of coordination, and nausea. Seek help! ...Read more

14

14
How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

15

15
Does periactin (cyproheptadine hydrochloride) lower blood serotonin levels? How long does it take to work?

Yes: Periactin (cyproheptadine hydrochloride) (cyproheptadine) can be used to treat serotonin syndrome but it is impossible to determine how long it takes to work considering each patient is different and separate. ...Read more

16

16
What does 80mg of Prozac (fluoxetine) do to a sex drive?

Depression: In some people it reduces libido. Talk to your doctor if you suffer this consequence as another anti depressant may be more in your interest. Also do not rely on meds alone to treat depression, psychotherapy is quite effective. My best. ...Read more

17

17
What is serotonin syndrome? What does it do to you?

What is serotonin syndrome? What does it do to you?

It is a serious side: effect that can be caused when one or more serotonergic medications is taken. Serotonin Syndrome can cause nausea /vomiting /diarrhea, abdominal pain, stiffness or spasm of muscles,
fever, shivering, ^ sweating, hallucinations, confusion, restlessness, visual changes, ^ Heart rate, tremor, lack of coordination, seizure, bp changes, dilated pupils, In some rarer cases, coma or death can occur. ...Read more

See 1 more doctor answer
18

18
Quetiapine and bupropion ... Would seem to be contraindicated w the 1st a dopamine receptor inhibitor and the 2nd a dopamine releaser?

Quetiapine and bupropion ... Would seem to be contraindicated w the 1st a dopamine receptor inhibitor and the 2nd a dopamine releaser?

Ask your doctor: There are many Dopamine receptors, and they are concentrated in different parts of your brain. If it were as easy as adding Dopamine and taking it away, things would be a lot easier. ...Read more

Dr. Andrew Ho Dr. Ho
8 doctors agreed:
19

19
Can some one tell me the best serotonin reuptake inhibitor to use for sadness?

Dr. Andrew Ho Dr. Ho
8 doctors agreed:

Like perfume: There is no best without considering personal context. Also, there may be quite a few that will work for any given patient. Your insurance company will prefer you start with lowest price product. Like perfume, if you like the effect, then it is best for you. Potential for drug-drug interaction can also be a consideration, but that is a complex analysis that you need to figure out with your doctor. ...Read more

20

20
Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?

Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?

Not correct: Serotonin does not deplete other neurotransmitters, but there is a balance especially between Dopamine and serotonin. This balance is dynamic and constantly re-establishing itself. Unless there is damage to neurons (which there can be when abusing certain drugs) neurotransmitter changes would not be permanent. ...Read more