Doctor insights on:
What Does A Serotonin Reuptake Inhibitor Do
Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more
I know that GABA inhibits release of dopamine, but what does glutamate do for dopamine? Precisely what would inhibition of NMDA do to dopamine?
Anti-convulsant: Some drugs that are used to treat seizures are GABA reuptake inhibitors. GABA is an inhibitory neurotransmitter and has an anti-seizure effect. These drugs reduce the reuptake of GABA into neurons and glia thereby increasing the amount of GABA available to interact with GABA receptors. ...Read more
How does strattera (atomoxetine) help for ADHD if it is a norepinephrine reuptake inhibitor , without affecting dopamine ?
Don't know!: If straterra is a norepinephrine reuptake inhibitor it increases the norepinephrine level in the brain. Methylphenidate stimulants, used in adhd work that way. In my opinion, straterra which was initially unsuccessfully marketed as an antidepressant is not a first line choice for adhd. ...Read more
Uniquely: Actually it it thought to restrain the effects of too much serotonin. It's complicated but the simple answer is NO - it does not work like an SSRI - nor other anti-anxiety drugs. Here's info but also ask your Dr and/or druggist. http://www.healthieryou.com/mhexpert/exp1041502a.html Best! ...Read more
What p450 enzymes are inhibited/induced by seroquel, (quetiapine) and what does a dopamine/norepinephrine antagonist do? Reduce dopamine levels? Specifics please?
Neither: Seroquel (quetiapine) passes through the cyp450 3a4 pathway & is extensively metabolized, but it neither inhibits nor induces the pathway itself. On the other hand, it's metabolism may be significantly affected by other medications. For instance, Dilantin induces the pathway causing seroquel (quetiapine) to be rushed through the pathway, leading to less-effective, lower blood levels. Antagonists are blockers. ...Read moreSee 1 more doctor answer
How does lyrica (pregabalin) work? Is it similiar to narcotic pain medicine? Or similiar to tramadol as norepinephrine and serotonin reuptake inhibitor?
Lyrica (pregabalin): Dear pika89800 lyrica enhances gaba in the brain and suppresses pain at a cortical level, pain has 3 main levels, local, spinal and brain (cortex), it is non narcotic, it is an antiseizure medication and can sometimes help both pain and anxiety the answer is purely for educational purposes, please contact your md. ...Read more
Stimulating: Ssris are all similar in how they work, but they vary in how "activating" or "stimulating" they are. A more activating ssri like Prozac can be caffeine-like: gives more energy but makes it hard to sleep. While all ssris can help anxiety, i tend to prefer less activating ones for this problem, as activation may temporarily worsen the feeling of anxiety. Less activating: paxil, (paroxetine) lexapro, celexa. ...Read moreSee 2 more doctor answers
GABA receptor: Like many ligands, gaba binds to its specific receptor, the gaba receptor (with several subtypes). Depending on the location of the gaba receptor, binding of gaba modulates various signaling pathways in the body. Note that gaba receptors are also found in organs outside of the brain. ...Read more
Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?
What is snri and how does it work? What drugs are in this class? Is tramadol an snri? What is seratonin syndrome? Do these treat depression and pain?
SNRI: Snri = serotonin norepinephrine reuptake inhibitor. Effexor, pristiq, meridia, savella (milnacipran), (milnacipran) and Cymbalta are in this class. Tramadol is not. When serotonin and norepinephrine are not taken back up into the neuron, they are more available in the synaptic cleft between neurons. Cymbalta & savella (milnacipran) treat fibro pain; the others more for depression. Cymbalta can treat depression; savella (milnacipran) perhaps less so. ...Read more
What happens if I take Zoloft and a mao inhibitor like marplan, nardil, and parnate (tranylcypromine)?
Contraindicated: Taking a monoamine oxidase inhibitor (maoi), such nardil, marplan, or Parnate (tranylcypromine) with a serotonin selective reuptake inhibitor (ssri) such as zoloft is contraindicated. When taken together they can lead to serotonin syndrome. This potentially deadly syndrome may cause agitation or restlessness, fast heart beat, hallucinations, increased body temperature, loss of coordination, and nausea. Seek help! ...Read more
Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more
It is a serious side:
effect that can be caused when one or more serotonergic medications is taken. Serotonin Syndrome can cause nausea /vomiting /diarrhea, abdominal pain, stiffness or spasm of muscles,
fever, shivering, ^ sweating, hallucinations, confusion, restlessness, visual changes, ^ Heart rate, tremor, lack of coordination, seizure, bp changes, dilated pupils, In some rarer cases, coma or death can occur. ...Read more
Quetiapine and bupropion ... Would seem to be contraindicated w the 1st a dopamine receptor inhibitor and the 2nd a dopamine releaser?
Ask your doctor: There are many Dopamine receptors, and they are concentrated in different parts of your brain. If it were as easy as adding Dopamine and taking it away, things would be a lot easier. ...Read more
Like perfume: There is no best without considering personal context. Also, there may be quite a few that will work for any given patient. Your insurance company will prefer you start with lowest price product. Like perfume, if you like the effect, then it is best for you. Potential for drug-drug interaction can also be a consideration, but that is a complex analysis that you need to figure out with your doctor. ...Read more
Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?
Not correct: Serotonin does not deplete other neurotransmitters, but there is a balance especially between Dopamine and serotonin. This balance is dynamic and constantly re-establishing itself. Unless there is damage to neurons (which there can be when abusing certain drugs) neurotransmitter changes would not be permanent. ...Read more
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