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Doctor insights on: What Does A Positive Skin Biopsy For Lupus Mean

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Can you do a skin biopsy for lupus with no rash and it be positive for lupus?

Can you do a skin biopsy for lupus with no rash and it be positive for lupus?

Possible: Would require getting a location that has the characteristics of lupus on examination. Not sure of the odds, but it would be possible. ...Read more

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Dr. Patrick Sweet III
117 Doctors shared insights

Skin Biopsy (Definition)

A skin biopsy is a way of getting a sample of skin for diagnostic purposes. There are two main ways of doing this. Shave biopsy. A blade is used to cut across the skin. It can leave a scar a bit like a golf divot. Punch biopsy. A device that looks like a little cookie cutter is used to take a cylinder of skin. This goes all the way through the skin and is ...Read more


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How accurate is a skin biopsy for lupus? Can you have a false/ positive test result?

How accurate is a skin biopsy for lupus? Can you have a false/ positive test result?

Lupus biopsy: Biopsy of lupus has a number of features that lead to diagnosis: a thickened basement membrane, vacuolar alteration of basal keratinocytes and superficial and deep inflammatory infiltrate. Lupus has a number of different forms in the skin and there are times when it is not easy to differentiate it from other types of skin inflammation. There are other tests to support diagnosis. ...Read more

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Would a skin biopsy for lupus still come up positive, even without a malar rash?

Would a skin biopsy for lupus still come up positive, even without a malar rash?

It can: There are many types of rash that can be seen in lupus. While the mal;ar or butterfly rash is the most common there are other lesions including the discoid rash of lupus. Many other rashes are also described as being seen in lupus. Even normal appearing skin can be positive for lupus using special stains and techniques. ...Read more

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I have symptoms of behcets and lupus. Neg ana, but positive lupus skin biopsy. Could I still have lupus?

I have symptoms of behcets and lupus. Neg ana, but positive lupus skin biopsy. Could I still have lupus?

Unlikely: Technically yes, but practically no, at least not the systemic form. I cannot remember the last time I saw ANA negative systemic lupus but anything is possible. ...Read more

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Does cutaneous lupus always present with positive ANA? What other tests besides skin biopsy can tell?

Does cutaneous lupus always present with positive ANA? What other tests besides skin biopsy can tell?

See below: There is no single test for lupus. A person can have lupus without ANA. The following website provides information about diagnostic criteria for lupus. May I add that there experts for such disease at UPMC in Pittsburgh.

http://forums. Webmd. Com/3/lupus-exchange/resource/26 ...Read more

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Can you be diagnosed with lupus with +ana homogenous pattern, inflammation shown in skin biopsy and symptoms that all point to lupus?

It depends: Nobody knows what lupus actually is, so it's diagnosed by criteria. Http://www. Rheumtutor. Com/2012-slicc-sle-criteria/ I need to give you 2 heads-up -- homogeoneous ANA pattern may be a lab error, and people who think they have lupus but don't meet the criteria tend to have a favorable prognosis. Wishing you the best -- the "brain fog" does make me think of lupus. Be strong ; stay proactive. ...Read more

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Skin biopsy on butrfly rashto dx? +ana 1:64, bilat joint pain photo sens, slightly elevated alpha 1 & 2? . Dbl strand ANA neg sed =1, -- lupus or not?

Skin biopsy on butrfly rashto dx? +ana 1:64, bilat joint pain photo sens, slightly elevated alpha 1 & 2? . Dbl strand ANA neg sed =1, -- lupus or not?

See below: It could be but without seeing the skin biopsy, performing an exam, and looking at the rest of your lab work, I can't make the call---only your treating physician can diagnose you. ...Read more

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What does it mean when a skin biopsy itches?

What does it mean when a skin biopsy itches?

Healing: Previous biopsy site itches, most probably because healing. If it is itching for a while show your doctor.
Thank for question. ...Read more

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My son had a skin biopsy (7 yrs). N the report says perivascular lymphoctic infiltrate with extravasated rbc. I need to know what does it mean.

My son had a skin biopsy (7 yrs). N the report says perivascular lymphoctic infiltrate with extravasated rbc. I need to know what does it mean.

Possibly viral: Many reactions to viruses have histology (microscopic appearance) with this description. Would need to see the entire report and slide to be sure. ...Read more

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Should I show the skin biopsy test of hpv16 positive to the surgeon?

Should I show the skin biopsy test of hpv16 positive to the surgeon?

Of course: You should share all of your health information with your doctors. ...Read more

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Subepithlial stroma is infiltrated with plasma cells. Plasma cells found in skin biopsy? What does it mean? Please explain?

Subepithlial stroma is infiltrated with plasma cells. Plasma cells found in skin biopsy? What does it mean? Please explain?

Nothing by itself: This could be any of dozens of skin problems, even a bug bite. You might ask whether the pathologist has any further clues, whether it's worth checking for IgG4-related skin disease, or whether to forget the whole thing. ...Read more

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What does moderate lymphocytic inflammatory infiltrate mean on a skin biopsy?

What does moderate lymphocytic inflammatory infiltrate mean on a skin biopsy?

Mgt: A virtual consult and uploading the report may be helpful. The type of lymphocytes is important, but this may indicate infection or inflammatory process not related to infection.
Do you have asthma? ...Read more

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Had skin biopsy 2.5 weeks ago ie 12 working days. Results still not in. Terrified this means it will be very bad news. Never taken this long before.

Delay in report: Does not necessarily mean bad report. Rather than worrying about it, please call your doctor and if s/he has not received the report request that your doctor call the pathologist to whom the biopsy was sent. ...Read more

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Is it common to have sarcoidosis diagnosed from a skin biopsy? Lung xray was negative. What does this mean?

Is it common to have sarcoidosis diagnosed from a skin biopsy? Lung xray was negative. What does this mean?

Sarcoidosis: Sarcoidosis can be suspected from a skin biopsy. Sarcoidosis primarily affects the lungs (90%), skin (25%) and eyes, although most other organs can be affected, including the nervous system and joints. There are other conditions that can look like sarcoidosis on biopsy include certain infections, foreign body reactions, drug reactions and other inflammatory conditions. These need to be excluded. ...Read more

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What it's mean if skin biopsy for small fiber neuropathy is normal in feet but not in hips?

What it's mean if skin biopsy for small fiber neuropathy is normal in feet but not in hips?

Can't conclude much: Except to say that whatever area they cored out from your feet didn't show evidence of changes in the skin, nerves, or muscles that could be classified as "neuropathic changes" whereas in the hip area they were able to make the call. A clinician looks at the whole picture, your symptoms, the physical examination, & lastly, biopsy results. You still may have foot neuropathy though test is NEGATIVE. ...Read more

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I have sle, my skin biopsy was positive for ana, iga, I also have raynaud's symptom, ra..... But all my blood test for ANA are neg, it's that posible?

See details: First of all the skin biopsy is not tested for ana. I doubt you have both sle and ra. Especially with a negative ana. Get another opinion. ...Read more

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Very itchy rash under arms and breast, behind knees and ears, inside elbows and in vaginal and anal area. Skin biopsy show eosinophils. What does this mean? Could this be a food sensitivity?

Very itchy rash under arms and breast, behind knees and ears, inside elbows and in vaginal and anal area. Skin biopsy show eosinophils. What does this mean? Could this be a food sensitivity?

Eosinophilic rashes: A variety of diseases can cause diffused skin rashes with eosinophilic infiltration including those mentioned in previous answers. However it seems like it affects both skin and mucus membrane and it is very diffused. Hypereosinophilic syndrome is a concern. Either an allergist, dermatologist, or hematologist can help you in this case. ...Read more

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Dr. Jan Lei Iwata
2 Doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more