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Doctor insights on: What Does A High Ana Titer Mean

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Is a high ANA titer of 1:640 or > and symptoms present for ctd early in diagnosis likely mean a bad prognosis or not necessarily?

Is a high ANA titer of 1:640 or > and symptoms present for ctd early in diagnosis likely mean a bad prognosis or not necessarily?

Not necessarily: The ANA titer will not correlate with disease activity. Your symptoms or what organ systems that are involved early in the disease course can sometimes be predictive of how the disease will be. If you have severe organ involvement requiring medications such Cytoxan (cyclophosphamide) that can sometimes be associated with a more worse prognosis. I hope that helps. Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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Hello, My ANA titer test came back as 1:320. What could this mean? It is quite high. Thank you.

Hello, My ANA titer test came back as 1:320. What could this mean? It is quite high. Thank you.

ANA titer: This as with many tests needs to be taken in context. We need to know why it was taken. What your symptoms are, what other tests were done, what the pattern showed, etc. Giving us one lab result and asking us what it means is like giving us one word from the bible and asking us what page it came from. The doctor who ordered the test is the best one to tell you or refer you to one who can. Read more

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Hx of seronegative RA yet recent labs show high crp/esr, absolute neutrophils and ANA by IFA but w/ no titer. What could that mean without a titer?

Hx of seronegative RA yet recent labs show high crp/esr, absolute neutrophils and ANA by IFA but w/ no titer. What could that mean without a titer?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab results suggest active on-going inflammation. The titer of ANA is not particularly relevant. Wish you good health. Read more

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I have a positive ANA titer 1:80 nuclear...And elevated C4 @ 76. I have fsgs, no diabetes and moderate hypertension. What does this mean?!

No disease probably: A woman at age 50 may have a low titer ANA without any disease to go with it. Primary fsgs is not associated with positive ana. An elevated c4 is an "acute phase reactant", meaning a protein that can be increased with a variety of diseases. Acute lupus erythematosus is associated with decreased c4. Moderate hypertension and elevated glucose do not explain the findings. Read more

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Hello My ANA titer test came back as 1:320. Is this very high? . Speckled pattern. I am quite concerned. Than you.

Is positive: This test is positive but only the doctor ordering it can explain to you the significance. ANA tests are notoriouisly positive in people without disease. Read more

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What does a positive result on the ANA titer mean?

Further testing: A positive ANA may not be significant. First of all why was the test done. If it was done for joint pain it will mean more then if a physiciab did one as a part of an annual physicial. Certainly, we are may be more concerned based on the value but also the pattern of the ana. The titer may mean an autoimmune disease is present based on the complaints, physical exam, and the values of other tests. Read more

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My ANA came back positive speckled with a titer of 1:1280. What does that mean for me?

See details: An ANA must be evaluated in the context of the entire clinical picture. You should ask this question to the doctor who ordered the test. Read more

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What does it mean if my ANA titer is <1:40 but my rnp is 128?

Caution: There are a huge number of labs in rheumatology, but especially with low-titer ANA and lowish-titer ribonucleoprotein, nobody's going to make the call of mixed connective tissue disease or anything else without a strongly supportive history and physical exam. Whenever arthritis is a consideration, a good trusting relationship with a rheumatologist is your best asset. Read more

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What does this mean (h) 1:8 titer, ANA patter (a) nucleolar, ANA screenifa (a) positive?

Depends on setting: The blood test by itself is not diagnostic. It depends on your clinical condition why the test was done as to whether it has any meaning at all. All this means is that you have an antibody against nucleus of the cell but that is not a diagnosis. Read more

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What is significance of ANA of 1:640 vs 1:320or 1:80.I know what the dilution means, but does higher titer even make a difference in clinical picture?

ANA titer matters.: ANA, or anti-nuclear antibody, is a a sensitive and specific test for systemic lupus erythematosus ONLY at high titer >1:320. Up to one in ten HEALTHY women can have a positive low-titer ANA, 1:40 or 1:80, which does NOT indicate lupus. Only a high-titer ANA can be used to diagnose lupus. To measure clinical activity in lupus, a different antibody called anti-double stranded DNA is measured. Read more

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What does titer with 180H with ANA IFA positive and homogeneous pattern mean?

ANA explanation: ANA are antinuclear antibodies which are seen in Systemic Lupus and some other disorders. Titer means how many dilutions in the test are still positive. The higher the number the more significant the test is clinically. 1:10-1:40 is low; 1 :80-1:320 is modest;1:680 and higher is high and very significant. Homogeneous is the most non-specific pattern seen even in drug-induced SLE. See your above. Read more

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Positive Ana with homogenous pattern titer of 1:160 does this most likely mean I have lupus?

No: This result is weakly positive or even normal in some individuals, positive ANA screen doesn't confirm a disease, it rather complements clinical signs and symptoms, other specific tests, imaging /tissue studies need to be performed in the context of the whole clinical picture. Seek a rheumatologist input if you're in doubt, wish you wellness Read more

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What does a variation in results for ANA blood test in the past all were negative what does it mean if the titer is 1:80 and a speckled pattern?

Not much: You need tests for specific antibodies in order to diagnose an auto-immune inflammatory condition such as lupus. See your doctor for complete evaluation. ANA has a high incidence of false positives. Read more

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What does a speckled result mean, when having as a result from blood work? The blood work test was an ANA with titer. My ANA was positive.

What does a speckled result mean, when having as a result from blood work? The blood work test was an ANA with titer. My ANA was positive.

SHAPE OF STAIN: Speak to the doctor who ordered the test. The titer result and pattern (speckled) may suggest a diagnosis of a connective tissue disease if correlated with the history and physical findings. Read more

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Is a ANA titer of 1:640, homogenous considered high? Rhuemy said I might have sle but would never diagnose in a male. Should I get a 2nd opinion?

Is a ANA titer of 1:640, homogenous considered high? Rhuemy said I might have sle but would never diagnose in a male. Should I get a 2nd opinion?

See details: That ANA is positive. If the clinical picture fits then you have sle regardless of whether you are male or female. Being a male does not exclude the diagnosis. Get a 2nd opinion if you are concerned. Read more