Doctor insights on:
What Does A High Ana Titer Mean
Is a high ANA titer of 1:640 or > and symptoms present for ctd early in diagnosis likely mean a bad prognosis or not necessarily?
Not necessarily: The ANA titer will not correlate with disease activity. Your symptoms or what organ systems that are involved early in the disease course can sometimes be predictive of how the disease will be. If you have severe organ involvement requiring medications such Cytoxan (cyclophosphamide) that can sometimes be associated with a more worse prognosis. I hope that helps. Read more
An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more
ANA titer: This as with many tests needs to be taken in context. We need to know why it was taken. What your symptoms are, what other tests were done, what the pattern showed, etc. Giving us one lab result and asking us what it means is like giving us one word from the bible and asking us what page it came from. The doctor who ordered the test is the best one to tell you or refer you to one who can. Read more
Hx of seronegative RA yet recent labs show high crp/esr, absolute neutrophils and ANA by IFA but w/ no titer. What could that mean without a titer?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab results suggest active on-going inflammation. The titer of ANA is not particularly relevant. Wish you good health. Read more
My ANA is positive and speckled 1:640 titer. Rheum dr tested me everything negative. Sed rate was a little elevated. Could that mean cancer?
I have a positive ANA titer 1:80 nuclear...And elevated C4 @ 76. I have fsgs, no diabetes and moderate hypertension. What does this mean?!
No disease probably: A woman at age 50 may have a low titer ANA without any disease to go with it. Primary fsgs is not associated with positive ana. An elevated c4 is an "acute phase reactant", meaning a protein that can be increased with a variety of diseases. Acute lupus erythematosus is associated with decreased c4. Moderate hypertension and elevated glucose do not explain the findings. Read moreSee 1 more doctor answer
Hello My ANA titer test came back as 1:320. Is this very high? . Speckled pattern. I am quite concerned. Than you.
Further testing: A positive ANA may not be significant. First of all why was the test done. If it was done for joint pain it will mean more then if a physiciab did one as a part of an annual physicial. Certainly, we are may be more concerned based on the value but also the pattern of the ana. The titer may mean an autoimmune disease is present based on the complaints, physical exam, and the values of other tests. Read more
Caution: There are a huge number of labs in rheumatology, but especially with low-titer ANA and lowish-titer ribonucleoprotein, nobody's going to make the call of mixed connective tissue disease or anything else without a strongly supportive history and physical exam. Whenever arthritis is a consideration, a good trusting relationship with a rheumatologist is your best asset. Read more
What is significance of ANA of 1:640 vs 1:320or 1:80.I know what the dilution means, but does higher titer even make a difference in clinical picture?
ANA titer matters.: ANA, or anti-nuclear antibody, is a a sensitive and specific test for systemic lupus erythematosus ONLY at high titer >1:320. Up to one in ten HEALTHY women can have a positive low-titer ANA, 1:40 or 1:80, which does NOT indicate lupus. Only a high-titer ANA can be used to diagnose lupus. To measure clinical activity in lupus, a different antibody called anti-double stranded DNA is measured. Read moreSee 2 more doctor answers
ANA explanation: ANA are antinuclear antibodies which are seen in Systemic Lupus and some other disorders. Titer means how many dilutions in the test are still positive. The higher the number the more significant the test is clinically. 1:10-1:40 is low; 1 :80-1:320 is modest;1:680 and higher is high and very significant. Homogeneous is the most non-specific pattern seen even in drug-induced SLE. See your above. Read more
No: This result is weakly positive or even normal in some individuals, positive ANA screen doesn't confirm a disease, it rather complements clinical signs and symptoms, other specific tests, imaging /tissue studies need to be performed in the context of the whole clinical picture. Seek a rheumatologist input if you're in doubt, wish you wellness Read more
Ok my test results came back from my ANA titer test and the doctor said 1- 320 and that its borderline. What's this mean?
What does a variation in results for ANA blood test in the past all were negative what does it mean if the titer is 1:80 and a speckled pattern?
What does a speckled result mean, when having as a result from blood work? The blood work test was an ANA with titer. My ANA was positive.
Is a ANA titer of 1:640, homogenous considered high? Rhuemy said I might have sle but would never diagnose in a male. Should I get a 2nd opinion?
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