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Doctor insights on: What Do Brca1 And Brca2 Stand For

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What do brca1 and brca2 stand for?

What do brca1 and brca2 stand for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

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Brca2 Gene (Definition)

This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more


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How do you perform tests for brca1 or brca2?

How do you perform tests for brca1 or brca2?

Blood test: Usually someone with breast cancer gets tested if there is an unusual family history, though it may be done more often now. Other family members may get genetic counseling and be offered the test as well. ...Read more

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What gene do I need to get tested for the familial colon cancer?

What gene do I need to get tested for the familial colon cancer?

Need more info: Totally different genes predispose to colon cancer, including BRCA 1 and 2; Familial Adenomatous Polyposis develops so many polyps in the colon they may be too numerous to count--but this one is quite rare. The commonest is Hereditary Non-Polyposis Colon Cancer. You may be at increased risk if close family members have developed it. See http://www.hopkinscoloncancercenter.org/CMS/CMS_Page.aspx? ...Read more

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How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40

How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40

See genetics: Most breast cancer is NOT due to an inherited risk, but rather occurs by chance. Family history that suggests an inherited risk, such as changes in the BRCA1 gene or BRCA2 gene, include multiple relatives with cancer over more than one generation and younger ages of onset. If you are concerned about an inherited risk, see a geneticist who can assess your family history. ...Read more

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What are the genetics tests for cml, can I get gene therapy if they find anything?

What are the genetics tests for cml, can I get gene therapy if they find anything?

Pcr-FISH-karyotype: There are 3 main types of genetic tests. The old standard is to take a blood sample from the hip (marrow) and grow cells to look at all the chromosomes (karyotype). It is a 'broad strokes' look but not as sensitive as the others. A fish test looks at blood cells with 'probes' to the known genetic changes (moderately sensitive) and a PCR test is a 'molecular' test of the dna (very sensitive). ...Read more

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Any stats on how many woman have been tested for the brca1 and brca2 gene?

Any stats on how many woman have been tested for the brca1 and brca2 gene?

Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more

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What is the recommended schedule for having mammograms when do not you have breast cancer history in your family?

What is the recommended schedule for having mammograms when do not you have breast cancer history in your family?

Yearly: Most groups recommend yearly mammograms after age 50. There are pros and cons to this, and other factors to consider besides family history, so it is worth discussing with your doctor what is the best screening regimen for you. ...Read more

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Mother diagnosis with breast cancer at 54, maternal grandmother diagnosis with pancreatic ca at 69. Dr's won't do brca test because there is no other breast/ovarian ca in my family. What do I do? I'm so worried.

Mother diagnosis with breast cancer at 54, maternal grandmother diagnosis with pancreatic ca at 69. Dr's won't do brca test because there is no other breast/ovarian ca in my family. What do I do? I'm so worried.

Screening: You should have clinical breast exams starting now, and then at age 40 start with yearly mammograms. It is possible to pay for the brca testing out of pocket if this is truly your desire, because would likely not be covered by insurance. ...Read more

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Please i need help...i want to know the cost of brca gene mutation ? And does the test found in all the countaries

Please i need help...i want to know the cost of brca gene mutation ? And does the test found in all the countaries

Variably expensive: These are very expensive tests and they are not necessary or indicated unless you have a close family history of breast cancer. Even then, having the mutation does not mean that you will definitely have cancer. Better to do annual mammograms and self exams. The tests are available in the US and many other countries but not everywhere and may cost US$2000-4000 ...Read more

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What to do if i need some ideas for a raise fund in my school to help breast cancer awareness?

What to do if i need some ideas for a raise fund in my school to help breast cancer awareness?

Here are some ideas: The american cancer society is a great source to find programs. The local hospital cancer centere might also bee able to help. The komen foundation might also be helpful. ...Read more

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What type of shoes are recommended for someone doing the 39 mile avon walk for breast cancer?

What type of shoes are recommended for someone doing the 39 mile avon walk for breast cancer?

Good support: I highly recommend that you find a store in your area that specializes in running shoes (not your local chain store). These stores are staffed with running enthusiasts and experts who can help you find the right shoe. Thank you for taking on this great task. Many breast cancer patients and researchers will benefit. Good luck! ...Read more

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3 family males including my dad died of skin cancer. Should i ask to be tested for the cancer gene?& what preventative can I do other than sunblock?

3  family males including my dad died of skin cancer.  Should i ask to be tested for the cancer gene?& what preventative can I do other than sunblock?

Melanoma?: There are a couple of melanoma genes, but ask yourself whether you'd do anything differently based on the results. You're going to use sunscreen, keep a very close eye on your skin, have somebody special (partner, dermatologist) look at where you can't see, and doing this will probably prevent a skin cancer death. ...Read more

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When do you get regular mammograms? Breast cancer does not run in my family, but i want to make sure i'm doing everything to stay in good health. At what age do you recommend women start getting mammograms?

When do you get regular mammograms? Breast cancer does not run in my family, but i want to make sure i'm doing everything to stay in good health. At what age do you recommend women start getting mammograms?

Currently, : Currently, at our institution we recommend that a woman with no risk factors begin yearly screening mammography at age 40. However, the recommendation for beginning screening mammography has become more controversial due to the recently published recommendations by the us preventative services task force which recommends screening mammography for women age 50 to 74 years. A rationale behind this recommendation is that screening mammography in women age 40 - 49 years results in more false positive results with comparatively few cancers detected. Currently, both the american college of radiology and the american cancer society recommend yearly screening beginning at 40 years of age. ...Read more

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What information do I have to bring along to do the preimplantation genetic screening?

What information do I have to bring along to do the preimplantation genetic screening?

Medical records: A complete medical history is important and useful...Bring all the information you have available to your doc/genetic counselor who can review the info and discuss with you about what you need/should do... Good luck... ...Read more

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What to do if i know radiation and chemotherapy are mainly for cancer but what is dialysis for?

What to do if i know radiation and chemotherapy are mainly for cancer but what is dialysis for?

Kidney failure: Dialysis replaces the function of the kidneys to filter byproducts out of your blood to create urine and avoid buildup of impurities in the blood. ...Read more

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How do you screen for breast cancer?

How do you screen for breast cancer?

Mammogram, etc.: The best test to screen for breast cancer is a mammogram. Most organizations in the US recommend beginning this at age 40, unless one is at high risk. This may be supplemented by yearly physician examination and monthly breast self-examination. ...Read more

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Do you think I should get mammograms earlier or be tested for the breast cancer gene?

Do you think I should get mammograms earlier or be tested for the breast cancer gene?

If you are: 45, you should already be getting mammograms according to ACS guidelines. If you have a strong family history, genetic testing might be appropriate, but talk to your doctor about it. ...Read more

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If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

Possibly: It's always better to test the family members who have breast cancer if possible. If they are first degree relatives (mother, daughter or sister) and one was under age 50 at diagnosis, you might meet criteria for brca testing. It's best to meet with a genetic counselor who can help guide you and your family so the correct people are tested. There are non-brca mutations as well. ...Read more

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I am about to get tested for the breast cancer gene. If positive should I get a mastectomy?

That is not a : Decision that should be made by an on-line doctor who does not know you or your personal history. That is a very individual decision that should be made carefully with full information about risks with and without surgery. ...Read more

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Why wouldnt I pay a few thousand usd to see if I carry the breast or ovarian cancer gene?

Why wouldnt I pay a few thousand usd to see if I carry the breast or ovarian cancer gene?

Family history: I have to assume you are talking about brac1 and 2 testing. Without a family history of breast or ovarian cancer your chance of having a mutation would be pretty low. With a family history, most insurance would cover at least part of the cost of the testing. Myriad, the lab which does the testing, would do an analysis for you to determine your out of pocket costs prior to running the test. ...Read more

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What do brca1 and brca2 stand for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

See 2 more doctor answers
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Do brca1 and brca2 mutations affect men the same way they affect women?

Do brca1 and brca2 mutations affect men the same way they affect women?

No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read more

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Brca1 and brca2 stands for?

Brca1 and brca2 stands for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

See 1 more doctor answer
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Who should take the brca1/brca2 test?

Know risk factors!: Genetic testing is recommended for: 1)a personal history of breast cancer at age 50 or younger 2)a personal history of triple negative breast cancer (breast cancer that is estrogen receptor-negative, Progesterone receptor-negative and her2/neu receptor-negative) 3)a personal or family history of male breast cancer 4)a personal or family history of bilateral breast cancer 5)history of ovarian cance. ...Read more

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How do you perform tests for brca1 or brca2?

Blood test: Usually someone with breast cancer gets tested if there is an unusual family history, though it may be done more often now. Other family members may get genetic counseling and be offered the test as well. ...Read more

See 1 more doctor answer
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If a man is found to have brca1 or brca2 mutations, what should his next step be?

If a man is found to have brca1 or brca2 mutations, what should his next step be?

Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read more

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What percent of women inherit a brca1 or brca2 gene?

Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more

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Any stats on how many woman have been tested for the brca1 and brca2 gene?

Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more

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Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read more

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How are brca1 and brca2 related to the development of breast cancer?

How are brca1 and brca2 related to the development of breast cancer?

Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

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I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more

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I am brca2 positive, what now?

I am brca2  positive, what now?

Ask your testing doc: I am sorry to hear of your worrisome news. The risk of developing breast cancer is very high being positive brca2, over 50% chance by age 70 (risk of +brca1 is even higher). This also increases risk of ovarian cancer, but to lesser extent. I would suggest doing additional research and talk to your doc who ordered the test. You may be referred to a breast surgeon etc...I wish you the best of luck. ...Read more

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Brca2 age 68. Should I get madtectomy?

Brca2 age 68. Should I get madtectomy?

Options:: are 1 prophylactic mastectomy with immediate reconstruction (see a plastic surgeon for both), 1 taking a drug for 5 years (see an oncologist), or very close surveillance alone- though I wouldn't recommend the 3d option... Have family members get gene testing ...Read more

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Can you tell me how I could find out the structure of the n terminus domain of brca2?

Can you tell me how I could find out the structure of the n terminus domain of brca2?

See article: From the following article: BRCA1 and BRCA2: different roles in a common pathway of genome protection Rohini Roy, Jarin Chun & Simon N. Powell Nature Reviews Cancer 12, 68-78 (January 2012) doi:10.1038/nrc3181 ...Read more

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Can you tell me how I could find out the "structure" of the n terminus domain of brca2?

Technical: Do a PUBMED search. But if you didn't know that already, it's unlikely you'll understand the answer you'll find there. What are you really asking about? ...Read more

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What does the brca2 gene mean as a guy?

BRCA2: Such men carry increased risk for breast and prostate cancers and should follow up with a specialist. ...Read more

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What is the definition or description of: brca2 gene?

What is the definition or description of: brca2 gene?

Cancer risk locus: This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make decisions to protect health. ...Read more

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If my mom has the brca2 gene but I don't, can insurance companies charge me more?

If my mom has the brca2 gene but I don't, can insurance companies charge me more?

Brac2gene: No that can not charge you more.Is your question about life insurance or medical insurance.Whatever you are negative for this gene and there should be no risks. ...Read more

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31, BRCA2 pos. 3.6cm cyst on right ovary that causes pain. Could be cancerous? CA125 is normal.

31, BRCA2 pos. 3.6cm cyst on right ovary that causes pain. Could be cancerous? CA125 is normal.

Insufficient info: The 3.6 cm size is not enough information to help determine if an ovarian cyst is malignant. Also, it is not clear that ovarian cancer screening will result in a decrease in the number of deaths in women with BRCA2. Instead, a surgical procedure that removes a woman’s ovaries and fallopian tubes should be considered upon conclusion of childbearing by women with documented inherited predisposition ...Read more