Doctor insights on:
What Do Brca1 And Brca2 Stand For
This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more
No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read moreSee 1 more doctor answer
Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read moreSee 1 more doctor answer
Know risk factors!: Genetic testing is recommended for: 1)a personal history of breast cancer at age 50 or younger 2)a personal history of triple negative breast cancer (breast cancer that is estrogen receptor-negative, Progesterone receptor-negative and her2/neu receptor-negative) 3)a personal or family history of male breast cancer 4)a personal or family history of bilateral breast cancer 5)history of ovarian cance. ...Read moreSee 1 more doctor answer
Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read moreSee 2 more doctor answers
Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more
Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more
Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read moreSee 1 more doctor answer
Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 1 more doctor answer
I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?
BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more
Ask your testing doc: I am sorry to hear of your worrisome news. The risk of developing breast cancer is very high being positive brca2, over 50% chance by age 70 (risk of +brca1 is even higher). This also increases risk of ovarian cancer, but to lesser extent. I would suggest doing additional research and talk to your doc who ordered the test. You may be referred to a breast surgeon etc...I wish you the best of luck. ...Read more
Options:: are 1 prophylactic mastectomy with immediate reconstruction (see a plastic surgeon for both), 1 taking a drug for 5 years (see an oncologist), or very close surveillance alone- though I wouldn't recommend the 3d option... Have family members get gene testing ...Read moreSee 2 more doctor answers
Technical: Do a PUBMED search. But if you didn't know that already, it's unlikely you'll understand the answer you'll find there. What are you really asking about? ...Read more
Cancer risk locus: This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make decisions to protect health. ...Read more
Insufficient info: The 3.6 cm size is not enough information to help determine if an ovarian cyst is malignant. Also, it is not clear that ovarian cancer screening will result in a decrease in the number of deaths in women with BRCA2. Instead, a surgical procedure that removes a woman’s ovaries and fallopian tubes should be considered upon conclusion of childbearing by women with documented inherited predisposition ...Read more
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