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Doctor insights on: What Do Brca1 And Brca2 Stand For

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What do brca1 and brca2 stand for?

What do brca1 and brca2 stand for?

BReast CAncer: The brca in brca1 and brca2 stands for breast cancer susceptibility gene. They are a type of gene known as tumor suppressor genes. ...Read more

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Brca2 Gene (Definition)

This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more


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Do brca1 and brca2 mutations affect men the same way they affect women?

Do brca1 and brca2 mutations affect men the same way they affect women?

No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read more

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Brca1 and brca2 stands for?

Brca1 and brca2 stands for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

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Who should take the brca1/brca2 test?

Who should take the brca1/brca2 test?

Know risk factors!: Genetic testing is recommended for: 1)a personal history of breast cancer at age 50 or younger 2)a personal history of triple negative breast cancer (breast cancer that is estrogen receptor-negative, Progesterone receptor-negative and her2/neu receptor-negative) 3)a personal or family history of male breast cancer 4)a personal or family history of bilateral breast cancer 5)history of ovarian cance. ...Read more

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How do you perform tests for brca1 or brca2?

How do you perform tests for brca1 or brca2?

Blood test: Usually someone with breast cancer gets tested if there is an unusual family history, though it may be done more often now. Other family members may get genetic counseling and be offered the test as well. ...Read more

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If a man is found to have brca1 or brca2 mutations, what should his next step be?

If a man is found to have brca1 or brca2 mutations, what should his next step be?

Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read more

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What percent of women inherit a brca1 or brca2 gene?

What percent of women inherit a brca1 or brca2 gene?

Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more

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Any stats on how many woman have been tested for the brca1 and brca2 gene?

Any stats on how many woman have been tested for the brca1 and brca2 gene?

Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more

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Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read more

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How are brca1 and brca2 related to the development of breast cancer?

How are brca1 and brca2 related to the development of breast cancer?

Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

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I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more

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I am brca2 positive, what now?

I am brca2  positive, what now?

Ask your testing doc: I am sorry to hear of your worrisome news. The risk of developing breast cancer is very high being positive brca2, over 50% chance by age 70 (risk of +brca1 is even higher). This also increases risk of ovarian cancer, but to lesser extent. I would suggest doing additional research and talk to your doc who ordered the test. You may be referred to a breast surgeon etc...I wish you the best of luck. ...Read more

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Brca2 age 68. Should I get madtectomy?

Brca2 age 68. Should I get madtectomy?

Options:: are 1 prophylactic mastectomy with immediate reconstruction (see a plastic surgeon for both), 1 taking a drug for 5 years (see an oncologist), or very close surveillance alone- though I wouldn't recommend the 3d option... Have family members get gene testing ...Read more

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Can you tell me how I could find out the structure of the n terminus domain of brca2?

Can you tell me how I could find out the structure of the n terminus domain of brca2?

See article: From the following article: BRCA1 and BRCA2: different roles in a common pathway of genome protection Rohini Roy, Jarin Chun & Simon N. Powell Nature Reviews Cancer 12, 68-78 (January 2012) doi:10.1038/nrc3181 ...Read more

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Can you tell me how I could find out the "structure" of the n terminus domain of brca2?

Technical: Do a PUBMED search. But if you didn't know that already, it's unlikely you'll understand the answer you'll find there. What are you really asking about? ...Read more

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What does the brca2 gene mean as a guy?

BRCA2: Such men carry increased risk for breast and prostate cancers and should follow up with a specialist. ...Read more

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What is the definition or description of: brca2 gene?

What is the definition or description of: brca2 gene?

Cancer risk locus: This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make decisions to protect health. ...Read more

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If my mom has the brca2 gene but I don't, can insurance companies charge me more?

If my mom has the brca2 gene but I don't, can insurance companies charge me more?

Brac2gene: No that can not charge you more.Is your question about life insurance or medical insurance.Whatever you are negative for this gene and there should be no risks. ...Read more

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31, BRCA2 pos. 3.6cm cyst on right ovary that causes pain. Could be cancerous? CA125 is normal.

31, BRCA2 pos. 3.6cm cyst on right ovary that causes pain. Could be cancerous? CA125 is normal.

Insufficient info: The 3.6 cm size is not enough information to help determine if an ovarian cyst is malignant. Also, it is not clear that ovarian cancer screening will result in a decrease in the number of deaths in women with BRCA2. Instead, a surgical procedure that removes a woman’s ovaries and fallopian tubes should be considered upon conclusion of childbearing by women with documented inherited predisposition ...Read more