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Doctor insights on: What Differences Are There In Megaloblastic Anemia And Pernicious Anemia

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What differences are there in megaloblastic anemia and pernicious anemia?

What differences are there in megaloblastic anemia and pernicious anemia?

Pernicious = Vit B12: Megaloblastic anemia refers to any condition which causes large red blood cells (folate (folic acid) deficiency, vitamin B12 deficiency, etc.) pernicious anemia can be thought of as a *type* of megaloblastic anemia which is caused by vitamin B12 deficiency secondary to malabsorption.

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Pernicious Anemia (Definition)

A decrease in red blood cells when the body can't ...Read more


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What is the difference between pernicious anemia and megaloblastic anemia?

Big RBC: Pernicious anemia is deficiency of vitaminb12 due to autoimmune attack on cell of the stomach and antibody against intrinsic factor- presented with megaloblastic anemia. Pa is only one of the causes of megaloblastic anemia- however other causes that can cause def vitb12, or folate (folic acid) or other drug eg. Bactrim- that inhibits dna synthesis in RBC production also can cause megaloblastic anemia.

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What is the difference between megaloblastic anemia and regular anemia?

What is the difference between megaloblastic anemia and regular anemia?

Cause: Megaloblastic anemia is caused by vitamin B12 or Folic Acid deficiency, or rarely from other causes. In the blood, the red blood cells are large. In the bone marrow, there is delayed maturation of the red blood cell precursors that give a characteristic appearance when stained and looked at under the microscope. There is no "regular anemia".

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What is a megaloblastic anemia?

What is a megaloblastic anemia?

Big red blood cell: Is a type of anemia presented with big size of red blood cells- that results from inhibition of dna synthesis during red blood cell production. This leads to continuing cell growth without division. It is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid, deficiency in micronutrient- as well as others including drugs/chemo etc. Work up needs to be done.

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Is megaloblastic anemia an inherited condition?

Is megaloblastic anemia an inherited condition?

Not commonly: Most cases of this condition reflect deficiencies of key vitamins (b12, folic acid) and occur due to dietary deficiencies, pregnancy, pernicious anemia, medications. Rare inherited forms can occur in which the carrier proteins for B12 may be low for example.

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Are there supplements for megaloblastic anemia?

Cause can be treated: The cause of megaloblastic anemia has to be determined. If it is due to vitamin B12 or Folic Acid deficiency, supplements can help. Many people with B12 deficiency cannot absorb B12 orally and may need to have it injected.

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How vit cyanoCObalamine deficiency causes megaloblastic anemia?

How vit cyanoCObalamine deficiency causes megaloblastic anemia?

B12: You need this vitamin to synthesize DNA (T's from U's). If you can't do this, the nuclear growth can't keep up with the cytoplasm and the red cells end up bigger before they can be released. Hence "megalo-".

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What's megaloblastic anemia?

What's megaloblastic anemia?

Anemia: Megaloblastic anemia is anemia related most commonly to vitamin B12 and Folic Acid deficiency. These problems are easily treated with replacement of the deficient vitamin. There are other much rarer causes of megaloblastic anemia, and other illnesses that may look similar to megaloblastic anemia.

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Is there a connection between megaloblastic anemia and nutrition?

Is there a connection between megaloblastic anemia and nutrition?

Maybe: The common causes of megaloblastic anemia are vitamin B12 deficiency and Folic Acid deficiency. A diet poor in these vitamins may lead to megaloblastic anemia.

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Does metformin cause megaloblastic anemia?

Does metformin cause megaloblastic anemia?

It can: Megaloblastic anemia is caused by a deficiency in vitamin B12 or folic acid. Taking metformin can cause your body to "use up" vitamin b12, and become deficient in b12, which, in severe cases, could lead to megaloblastic anemia. This can usually be corrected with a vitamin B12 pill, unless there is also a problem with absorbing b12.

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How follic acid deficiency causes megaloblastic anemia?

It just does :): Hello- your body needs Folic Acid to make red blood cells properly. If you do not have enough it compromises the process. The body will not be able to produce red blood cells as well (anemia) and they will be bigger than normal red blood cells (megaloblastic = big). Thankfully some Folic Acid replacement should fix the problem quite easily.

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What is the relationship between megaloblastic anemia and nourishment?

Megaloblastic anemia: Megaloblastic anemia is macrocytic anemia (elevated mcv/large rbc) that results fron inhibition of dna synthesis in RBC production. This can be caused by deficiency in vit b12, folate (folic acid) or drug induced. If you are a strict vegan- you are at risk to have vit B12 deficiency-thus you should take vit B12 supplement. Check and discuss further in detail with your doctor.

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Megaloblastic anemia can lead to some neurological disorders?

Megaloblastic anemia can lead to some neurological disorders?

Yes: Megaloblastic anemia is most commonly caused by vitamin B12 or Folic Acid deficiency. Neurologic symptoms might include weakness, numbness, difficulty walking and with balance.

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Can you tell me is folic acid defiency anemia and megaloblastic anemia the same thing?

Can you tell me is folic acid defiency anemia and megaloblastic anemia the same thing?

Partially: Folic acid or folate (folic acid) deficiency is one of the causes of megaloblastic anemia but there are others including vitamin B12 deficiency, myelodysplastic syndromes, other blood cancers, genetic disorders, etc.

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Why we treat megaloblastic anemia caused by vitamin B12 deficiency with folates (folic acid)?

Why we treat megaloblastic anemia caused by vitamin B12 deficiency with folates (folic acid)?

We don't: Megaloblastic anemia caused by B12 deficiency is treated with b12. Folate (folic acid) deficiency also causes meg. Anemia. Some with B12 deficiency are also deficient in b12, but if one has low B12 ; isn't deficient in folate (folic acid) there's no need to supplement with it. But it won't hurt to take folate (folic acid);if you're among the 1/3 of people with problems converting Folic Acid to it's active form you should take l-5-mthf.

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What's the difference between pernicious anemia and B12 anemia?

What's the difference between pernicious anemia and B12 anemia?

See below: B-12 anemia is a deficiency in vitamin b-12 (cobalamin). Pernicious anemia is a deficiency or lack in intrinsic factor (produced by cells in the stomach) which is a protein essential for absorption of vitamin B12 in the ileum (small intestine). Pernicious anemia requires replacement of intrinsic factor &/or b-12. B-12 anemia needs only b-12 supplementation.

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Can pernicious anemia be cured?

Can pernicious anemia be cured?

Not usually.: Classical pernicious anemia is caused by auto-antibodies against intrinsic factor-producing parietal cells of the stomach. Treatment is lifelong vitamin B12 administration, which is safer than using immunosuppressive medications that could lead to severe infections. Other kinds of B12 deficiency can possibly cured depending on the cause.

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Is pernicious anemia life-shortening?

Is pernicious anemia life-shortening?

Typically not: Pernicious anemia when treated with life long B12 replacement confers a normal lifespan. There is an increased risk of stomach cancer in some cases which can affect survival times.

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Could pernicious anemia shorten life?

Probably no: If you have pernicious anemia you do not absorb B12 effectively. That is easily fixed with either B12 injections or large B12 oral doses daily. Unfortunately, patients with B12 deficiency often have other associated autoimmune issues that develop. In general though, pa alone will not shorten life as long as you treat it correctly.

Dr. Steven Ginsberg
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Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more