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Doctor insights on: What Differences Are There In Megaloblastic Anemia And Pernicious Anemia

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What differences are there in megaloblastic anemia and pernicious anemia?

What differences are there in megaloblastic anemia and pernicious anemia?

Pernicious = Vit B12: Megaloblastic anemia refers to any condition which causes large red blood cells (folate (folic acid) deficiency, vitamin B12 deficiency, etc.) pernicious anemia can be thought of as a *type* of megaloblastic anemia which is caused by vitamin B12 deficiency secondary to malabsorption. ...Read more

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Pernicious Anemia (Definition)

It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily ...Read more


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What is the difference between pernicious anemia and megaloblastic anemia?

Big RBC: Pernicious anemia is deficiency of vitaminb12 due to autoimmune attack on cell of the stomach and antibody against intrinsic factor- presented with megaloblastic anemia. Pa is only one of the causes of megaloblastic anemia- however other causes that can cause def vitb12 , or folate (folic acid) or other drug eg. Bactrim- that inhibits dna synthesis in RBC production also can cause megaloblastic anemia. ...Read more

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What is the difference between megaloblastic anemia and regular anemia?

What is the difference between megaloblastic anemia and regular anemia?

Cause: Megaloblastic anemia is caused by vitamin B12 or Folic Acid deficiency, or rarely from other causes. In the blood, the red blood cells are large. In the bone marrow, there is delayed maturation of the red blood cell precursors that give a characteristic appearance when stained and looked at under the microscope. There is no "regular anemia". ...Read more

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What is a megaloblastic anemia?

Big red blood cell : Is a type of anemia presented with big size of red blood cells- that results from inhibition of dna synthesis during red blood cell production.This leads to continuing cell growth without division. It is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid, deficiency in micronutrient- as well as others including drugs/chemo etc. Work up needs to be done. ...Read more

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Is megaloblastic anemia an inherited condition?

Is megaloblastic anemia an inherited condition?

Not commonly: Most cases of this condition reflect deficiencies of key vitamins (b12, folic acid) and occur due to dietary deficiencies, pregnancy, pernicious anemia, medications. Rare inherited forms can occur in which the carrier proteins for B12 may be low for example. ...Read more

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Are there supplements for megaloblastic anemia?

Cause can be treated: The cause of megaloblastic anemia has to be determined. If it is due to vitamin B12 or Folic Acid deficiency, supplements can help. Many people with B12 deficiency cannot absorb B12 orally and may need to have it injected. ...Read more

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How vit cyanoCObalamine deficiency causes megaloblastic anemia?

How vit cyanoCObalamine deficiency causes megaloblastic anemia?

B12: You need this vitamin to synthesize DNA (T's from U's). If you can't do this, the nuclear growth can't keep up with the cytoplasm and the red cells end up bigger before they can be released. Hence "megalo-". ...Read more

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Whats megaloblastic anemia?

Whats megaloblastic anemia?

Anemia: Megaloblastic anemia is anemia related most commonly to vitamin B12 and Folic Acid deficiency. These problems are easily treated with replacement of the deficient vitamin. There are other much rarer causes of megaloblastic anemia, and other illnesses that may look similar to megaloblastic anemia. ...Read more

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Is there a connection between megaloblastic anemia and nutrition?

Maybe: The common causes of megaloblastic anemia are vitamin B12 deficiency and Folic Acid deficiency. A diet poor in these vitamins may lead to megaloblastic anemia. ...Read more

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Does metformin cause megaloblastic anemia?

Does metformin cause megaloblastic anemia?

It can: Megaloblastic anemia is caused by a deficiency in vitamin B12 or folic acid. Taking metformin can cause your body to "use up" vitamin b12, and become deficient in b12, which, in severe cases, could lead to megaloblastic anemia. This can usually be corrected with a vitamin B12 pill, unless there is also a problem with absorbing b12. ...Read more

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Dr. Steven Ginsberg
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Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more