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Doctor insights on: What Condition Might Cause An Elevated Alkaline Phosphatase

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Dr. Andrew Seibert
666 Doctors shared insights

Alkaline Phosphatase (Definition)

The normal range is 20 to 140 iu/l.[12] high levels can indicate active bone formation occurring as alp is a byproduct of osteoblast activity (such as the case in paget's disease of bone). Levels are also elevated in people with untreated celiac ...Read more


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Can a stomach virus/bug on the day I did bloodwork cause an elevated alkaline phosphatase level? All other values in range and I have hep b.

Can a stomach virus/bug on the day I did bloodwork cause an elevated alkaline phosphatase level? All other values in range and I have hep b.

How elevated?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, GI lesions can raise alkaline phosphatase, but more common causes are disease in the liver and bone. It would be helpful for you to discuss it with your doctor. ...Read more

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What are the causes for elevated alkaline phosphatase?

What are the causes for elevated alkaline phosphatase?

Liver bone & GB: Liver disease, bone disease and gallbladder are most common. However an elevated alk phos does not absolutely mean there is a true disease present. ...Read more

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What causes bone pain and elevated alkaline phosphatase in women?

Several conditions: You could have the condition called paget's disease, however they are some other diseases that could produce elevated alkaline phosphatase such as liver cirrhosis of obstruction of the biliary tract, some medications and some type of cancers. Proper testing is necessary for proper diagnosis. ...Read more

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What could cause alkaline phosphatase levels to steadily increase over a period of years, now at an elevated level?

Alkaline phosphatase: Causes for elevated Alk phos: biliary obstruction stone, tumor, stricture; autoimmune biliary cirrhosis; liver infiltrates do to granuloma, fatty liver, amyloidosis, sarcoidosis, malignancy; meds like estrogen, chlorpromazine, erythromycin ; viral hepatitis; bone diseases: Paget's, osteomalacia, mets to bone, PTH disease, vitamin d def, fracture ...Read more

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Does elevated alkaline phosphatase cause bone pain?

Does elevated alkaline phosphatase cause bone pain?

No: Alkaline phosphatase is known as a "marker" of increased bone (or liver) metabolism. It is contained in bone (and liver) so it will be elevated when bone is being broken down or resorbed as in paget's disease or bone cancer. It doesn't cause bone pain per se, but whatever is causing the bone to break down in the first place (e.g. Paget's disease or bone cancer) is the cause of the pain. ...Read more

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Slightly elevated AST ALT and alkaline phosphatase in otherwise healthy woman. Concerned. Should I be? What could be the cause?

Slightly elevated AST ALT and alkaline phosphatase in otherwise healthy woman. Concerned. Should I be? What could be the cause?

Need more info: What are the actual values? Do you drink alcohol? If you do, abstain for three months and redo the tests. Please note that all lab results need to be interpreted in the context of all other health information. ...Read more

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What can cause elevated alkaline phosphatase, beta globulin, TIBC, Compliment 3 +4, C-react. Protein and low ferritin, MCV, MCG and iron saturation?

Low iron: Elevated alk phos is seen with liver and bone disorder. Iron deficiency is suspected, but chronic inflammation may cause most of the lab abnormalities. A hematologist could shed some light on these varied lab abnormalities. Collaboration with a rheumatologist would also be helpful to identify a chronic inflammatory process. ...Read more

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Alkaline phosphatase elevated should I be concerned?

Depends: This depends on how elevated the levels are and whether you have any associated conditions (for example, pregnancy) which are known to cause elevated levels. Talk to your doctor for more information. ...Read more

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What could cause abnormal levels of alkaline phosphatase?

Bone diseae/gallblad: Alkaline phosphotase is elevated in diseaes of gall bladder/liver or diseases of bones. ...Read more

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What does it mean when alkaline phosphatase, MCV, MCH & MCHC are elevated?

Mixed bag: ALP is a liver (or bone) enzyme; MCV; MCH and MCHC refer to size and color of red blood cells as in macrocytic (big red cell) anemia - given your conditions and meds, I would ask your doctor if you may have a B12 or Folic Acid deficiency ...Read more

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What could cause an AST of 62, ALT of 153 and alkaline phosphatase of 128?

Lots of things: Medication sensitivity, boozing, being overweight / sedentary, hepatitis b or c, a sports injury, just finishing a marathon, hemochromatosis, wilson's, autoimmune hepatitis, antitrypsin deficiency, a host of others. One good plan is no alcohol or meds for two weeks, see if this goes down. ...Read more

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Is a blood level alkaline phosphatase of 46 (range 45 - 129) normal or low? Could it cause problems?

It's fine: A low alkaline phosphatase level never means anything, and reference ranges are set so that several percent of healthy folks fall outside in the first place. Stop worrying and be grateful for good health. ...Read more

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What are the causes of and how can the levels be reduced of serum creatinine, serum alkaline phosphatase?

Increase GFR: Creatinine can be reduced by losing muscle mass or by increasing renal function. Starvation will do the first, correction of obstruction or stenosis or potential decrease in ace inhibitors or arbs or Cimetidine #2. ...Read more

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Elevated ALT levels and alkaline phosphatase direct bilirubin is. 2 not very old only 18 gained about 30 pounds in 3 months what do these test mean?

Elevated ALT levels and alkaline phosphatase direct bilirubin is. 2 not very old only 18 gained about 30 pounds in 3 months what do these test mean?

U R seriously sick: I see you are an 18 year old male taking "provigil", a stimulant prescribed for sleep apnea and narcolepsy and used illicitly to promote wakefulness. It can poison your liver and you need to talk with your physician about this. The fact that you've gotten fat in 3 months is very worrisome. Your doctor must rule hepatitis, hemochromatosis, wilson's, fatty liver and more in or out. ...Read more

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I recently had lab work done and my Alkaline phosphatase results were 39-117, which, to my understanding is elevated. What could this mean. I a 35 fe?

I recently had lab work done and my Alkaline phosphatase results were 39-117, which, to my understanding is elevated. What could this mean. I a 35 fe?

Normal range: I think this is a misunderstanding. Your measured value would be a single number, such as103. The numbers you provide are a range of values which are well within normal for alkaline phosphatase. What this means is that we don't know what your ALKPHOS level is. I suggest you contact your health care provider for clarification. Meanwhile, no worries! ...Read more

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Hi, my ALT is slightly elevated at 57. My AST is normal at 32 and my Alkaline Phosphatase is normal at 77. I'm a 25 yr old male. What may this indicate?

Hi, my ALT is slightly elevated at 57. My AST is normal at 32 and my Alkaline Phosphatase is normal at 77. I'm a 25 yr old male. What may this indicate?

Normal: ALT normal value are 5 to 56 and yours is 57.I will not worry about your blood test report. I don't know if it was on routine blood test or there was a reason to check your Liver Function. Follow up with your Doctor if it was done foe a reason. ...Read more

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I am having low and high alkaline phosphatase result. Ultrasound and X-ray report shows a healthy liver. What could be the cause?

I am having low and high alkaline phosphatase result. Ultrasound and X-ray report shows a healthy liver. What could be the cause?

Many sources: Alkaline phosphate is high due to multiple reasons. They get high due to problem in liver, bone or intestine. It's unclear if your level gets to normal. It will be wise to discuss with pcp. ...Read more

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Could having a blood test only two days after a cellulitis flare up cause my liver levels, as well as my alkaline phosphatase to go up?

Could having a blood test only two days after a cellulitis flare up cause my liver levels, as well as my alkaline phosphatase to go up?

Possibly: Any infection, like a cellulitis can cause a systemic response leading to inflammation of other organs including your liver. Medications you are taking such as antibiotics, can also cause elevated liver enzymes and an elevated alk phosphatase level ...Read more

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I constantly have an elevated white blood cell count and alkaline phosphatase levels currently at 196 I am female 56.

I constantly have an elevated white blood cell count and alkaline phosphatase levels currently at 196 I am female 56.

How do you FEEL?: Around 5% of older folks always run elevated alk phos and trying to work it up never produces anything helpful; if the specimen is nonfasting and you don't have A antigen on your red cells, it's often high from intestinal alk phos. If all WBC's are normally formed and other cells are normal, I'd worry only if the WBC is very high. Lab "normals" are set so that several % of healthies are outside ...Read more

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Hx of rectal ca sp LAR, CEA 4m interval rise from <0.5 to 2.4, Bilirubin 0.4, alkaline phosphatase 46, ALT 46, but high AST 79. What's the cause?

LIVER PROBLEM: No evidence with the tests that there is recurrent rectal Ca. The AST or SGOT suggests there is some form of liver damage that should be evaluated by scan and possible liver biopsy. ...Read more

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What type of treatment is given to patients with elevated levels of sgot, sgpt and alkaline phosphatase?

What type of treatment is given to patients with elevated levels of sgot, sgpt and alkaline phosphatase?

Depends on the cause: We do not treat the tests but what is the reason for the abnormal tests
it may be due to gall bladder disease, or liver condition and the underlying condition has to be addressed and treated. ...Read more

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My daughter's blood test showed she had a bilirubin of 41 with normal ALT and alkaline phosphatase. Why could this be and could it cause nausea?

Inconsistent results: Please consult your doctor to redo the test. It is not likely that she has this high a bilirubin with normal liver enzymes. ...Read more

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My alkaline phosphatase is 276, ALT is 62 & AST 35. I had an US & EUS both - for gallstones. Now my total igA is elevated. What do you think?

Ask your doctor: Sketchy picture, moreover lab results cannot be interpreted out of context, patient need to be evaluated as a whole, your doctor would help you better ...Read more

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I have alkaline phosphatase elevated (450u/l) as well as (sgpt), (sgot), and ama test is positive, age 37y (woman), have anaemia and low level of iron?

Sort this out: You need to be told straight-up whether you are going to be diagnosed with & treated for primary biliary cirrhosis. If you also have iron deficiency anemia, the cause needs to be found. I hope you are not a non-supplementing vegetarian & that a search for possible sources of blood loss is underway. Be proactive & insist on answers. Good luck. ...Read more

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Doctor have migraine headache from 12yrs and elevated alkaline phosphatase level of about 370 iu? Treatment dr

Let's sort out: Your alkaline phosphatase could be elevated due to bone or liver. Therefore preventative meds should be devoid of bad effects to these organs. Some drugs cause osteoporosis, and others are metabolized through liver. Would suggest safest approach using otc preps such as butterbur, feverfew, coq-10, or riboflavin. ...Read more

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Elevated alkaline phosphatase value of 125 U/L. Is this a sign of primary biliary cirrhosis? Could the level be due to my Hep B?

Elevated alkaline phosphatase value of 125 U/L. Is this a sign of primary biliary cirrhosis? Could the level be due to my Hep B?

High level,,,: This is a high level for alkaline phosphatase certainly, but to say it's from primary biliary cirrhosis is harder as there are other things like high bilirubin and symptoms like itching and jaundice (yellow skin) and antibodies like anti-mitochondrial antibodies. It also could be due to Hep B or any increased liver activity or other things and it's not that high so see your Dr. For other tests. ...Read more